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Drop pills for treating asthma cough and preparation method thereof

The technology of dripping pills and preparations is applied in the field of dripping pills for treating asthma and cough and its preparation field, which can solve the problems of poor stability of oral liquids, complex Chinese patent medicines, and poor stability of injections, and achieves controllable quality, convenient storage, and stability. good effect

Inactive Publication Date: 2007-08-08
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex composition of Chinese patent medicines, injections have poor stability and large side effects, while oral liquids have poor stability and are inconvenient to carry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The weight portion proportioning of drop pill preparation is:

[0018] Ephedra 450

[0019] Datura 150

[0020] Bitter almonds 120

[0021] pinellia 100

[0022] Polyethylene glycol 2000 100

[0023] Polyethylene glycol 6000 230

[0024] The preparation method is:

[0025] (1) Preparation of the extract: smash the Chinese medicine Ephedra, together with Dajinhua, Bitter Almond, and Pinellia, extract twice with 12 times the amount of hydrochloric acid aqueous solution (0.03%), each time for 2 hours, filter, and combine the filtrates. Concentrate under reduced pressure at 60°C to form a thick ointment (herb: thick ointment=2:1). Add 2% alkaline reagent and ethanol in the amount of medicinal materials to make the ethanol content 70%, stir for 30 minutes, let it settle for 3 hours, take the supernatant and adjust the pH to 7 with dilute acid, filter, reclaim the ethanol from the filtrate, reduce Compress and concentrate into a thick paste (solid content 75%), set asi...

Embodiment 2

[0029] The weight portion proportioning of drop pill preparation is:

[0030] Ephedra 400

[0031] Datura 100

[0032] Bitter almonds 80

[0033] Bellflower 70

[0034] Polyethylene glycol 2000 100

[0035] Polyethylene glycol 4000 200

[0036] The preparation method is:

[0037] (1) Preparation of the extract: smash the Chinese herbal ephedra together with datura japonica, bitter almond and platycodon grandiflorum, extract twice with 10 times the amount of hydrochloric acid aqueous solution (0.01%), each time for 2 hours, filter, and combine the filtrates, 550 Concentrate under reduced pressure at ℃ to form a thick ointment (herb: thick ointment=2:1). Add the alkaline reagent and ethanol of 1.5% medicinal material amount to make the ethanol content be 70%, stir for 30 minutes, let stand and settle for 3 hours, take the supernatant and adjust the pH to 7 with dilute acid, filter, reclaim the ethanol from the filtrate, reduce Press and concentrate to form a thick paste (...

Embodiment 3

[0041] The weight portion proportioning of drop pill preparation is:

[0042] Ephedra 500

[0043] Datura 200

[0044] Bitter almonds 100

[0045] Forsythia 80

[0046] Bellflower 100

[0047] Polyethylene glycol 4000 100

[0048] Polyethylene glycol 8000 250

[0049] The preparation method is:

[0050] (1) Preparation of the extract: crush the Chinese medicine Ephedra, together with Dajinhua, Bitter Almond, Forsythia, and Campanulaceae, extract twice with 10 times the amount of hydrochloric acid aqueous solution (0.06%), each time for 2 hours, filter, and combine The filtrate was concentrated under reduced pressure at 60°C to form a thick ointment (herb: thick ointment=2:1). Add alkaline reagent and ethanol with 1% medicinal material amount to make the ethanol content 70%, stir for 30 minutes, let it settle for 2 hours, take the supernatant and adjust the pH to 7 with dilute acid, filter, reclaim the ethanol from the filtrate, reduce Press and concentrate to form a th...

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Abstract

The invention relates to a drop agent used to treat asthma and relative preparation. Via tests, the invention uses the Chinese ephedra and datura flower as main drugs, at 300-600 and 100-300 mass ratios. And the invention can add 100-400 deals of drug X and 100-500 deals of findings. The invention has the functions as resolving phlegm and relieving cough, or the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a drop pill preparation for treating asthma and cough and a preparation method thereof. Background technique [0002] Asthma is one of the most common diseases in clinical practice. No matter in the past or now, it is considered as one of the more difficult diseases by traditional Chinese medicine or Western medicine. At present, there is still a lack of ideal Chinese and Western medicines. [0003] According to the world's first asthma day (98.12.11), there are 150 million people in the world and 25 million people in China suffer from asthma. According to reports, the current incidence rate of asthma in the world is 1-3%, and the incidence rate and fatality rate in most countries are still increasing year by year. Disabilities and asthma are many and difficult to cure, which has become a concern of the whole society. Western medicine uses hormones and anticholinerg...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K36/9068A61K9/20A61K47/34A61P11/06A61P11/14A61K47/10
Inventor 朱盛山李苑新姜红宇霍务贞
Owner GUANGDONG PHARMA UNIV
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