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Intestinal flora capsule for treating methylamphetamine addiction withdrawal and preparation method

A technology of methamphetamine and intestinal flora is applied in the directions of capsule delivery, medical raw materials derived from bacteria, medical preparations containing active ingredients, etc. craving effect

Inactive Publication Date: 2019-10-01
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology uses ingested food containing certain types of bacillus called Rhombic Coccosis (RCA) that helps reduce harm from opiates like morpholine by blocking their ability to make new substances similar to those made through other methods. It also suggests adding these bacteals together during surgery when patients have been given this medicine before going on chemotherapies. Overall, it provides technical benefits over existing ways of administering medications while reducing negative reactions caused by use of narcistropic agents.

Problems solved by technology

The technical problem addressed in this patented study relates to finding effective methods for preventing substances like drugs from causing harmful side effects during use while promoting regulation of gut flora functions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation method of the intestinal flora capsule of the present embodiment is as follows:

[0047] S1. Collect fresh feces from healthy people, seal them in sealed bags, and keep them for later use.

[0048] S2. Weigh 50g of fresh feces collected in S1, measure 150mL of sterile saline, stir and mix the weighed fresh feces and sterile saline to obtain a suspension, and filter the suspension with 3 layers of gauze to remove residues , to obtain the intestinal flora bacterial liquid. Store the intestinal flora liquid in a refrigerator at 2-5°C for future use.

[0049] S3. Smear the intestinal flora bacterial liquid on the RGCA solid medium, and after culturing for 24 hours, inoculate the colony grown in the RGCA solid medium into a culture tube containing RGCA liquid medium, and culture on a shaker After 12 hours, the target bacterial liquid is obtained, that is, Ruminococcus albicans or Ruminococcus xanthophyllum is extracted from the intestinal flora bacterial li...

Embodiment 2

[0053] The preparation method of the intestinal flora capsule of the present embodiment is as follows:

[0054] S1. Collect fresh feces from healthy people, seal them in sealed bags, and keep them for later use.

[0055] S2. Weigh 50 g of fresh feces collected in S1, measure 300 mL of sterile saline, stir and mix the weighed fresh feces and sterile saline to obtain a suspension, transfer the suspension into a sterile centrifuge tube, and Centrifuge for 20 min under the conditions of centrifugal force 2500-3000xg and temperature 20-25°C, take out the supernatant in the sterile centrifuge tube, and obtain the intestinal flora bacterial liquid. Store the intestinal flora liquid in a refrigerator at 2-5°C for future use.

[0056] S3. Smear the intestinal flora bacterial liquid on the RGCA solid medium, and after culturing for 24 hours, inoculate the colony grown in the RGCA solid medium into a culture tube containing RGCA liquid medium, and culture on a shaker After 12 hours, th...

Embodiment 3

[0060] The preparation method of the intestinal flora capsule of the present embodiment is as follows:

[0061] S1. Collect fresh feces from healthy people, seal them in sealed bags, and keep them for later use.

[0062] S2. Weigh 50 g of fresh feces collected in S1, measure 200 mL of sterile saline, stir and mix the weighed fresh feces and sterile saline to obtain a suspension, transfer the suspension into a sterile centrifuge tube, and Centrifuge at a low speed for 20 minutes at a centrifugal force of 2500-3000xg and a temperature of 20-25°C, take out the supernatant in the sterile centrifuge tube after low-speed centrifugation, transfer the supernatant to a new sterile centrifuge tube, and centrifuge at a centrifugal force of 6000- Centrifuge at a high speed for 30 min at 8000×g and a temperature of 15-20° C., take out the supernatant in the sterile centrifuge tube after high-speed centrifugation, and obtain the intestinal flora bacterial liquid. Store the intestinal flora...

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Abstract

The invention relates to the technical field of fecal bacteria capsules, in particular to an intestinal flora capsule for treating methylamphetamine addiction withdrawal and a preparation method. Thepreparation method comprises the steps that fresh feces of healthy people is adopted to be stirred with sterile physiological saline to prepare a suspension, filtering and residue removing are conducted, and intestinal flora liquid is obtained; by means of a special culture medium, ruminococcus albus and ruminococcusflavefaciens are extracted from the intestinal flora liquid for culture, and a target bacteria solution is obtained; CaCl2 is added into the target bacteria solution, and then mixed with a glue solution prepared from sodium alginate and pectin, a chemical cross-linking reaction isconducted at room temperature, filtering and cleaning are conducted, intestinal flora particles are obtained and wrapped in the capsule, and the intestinal flora capsule is obtained and preserved at room temperature in the dark. The prepared intestinal flora capsule can adjust the intestinal flora composition of an addict, withdrawal of the methylamphetamine drug addiction is achieved, the cravingof the addict on the drugs is gradually reduced, the intestinal microecological balance of the addict is controlled, and the drug withdrawal rate is effectively improved.

Description

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Claims

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Application Information

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Owner SOUTHWEST UNIVERSITY
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