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Pharmaceutical composition for easing pain and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve problems such as toxicity, non-ventilator, addictive liver and kidney, etc., achieve less side effects, safe and convenient management , fast-acting effect

Inactive Publication Date: 2014-12-03
赵明强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The qualitative research on the pain experience of burn patients and the qualitative research on medical staff showed that the influencing factors of poor pain control in burn dressing operation are as follows: ①Opioid analgesics addiction and respiratory Inhibited adverse reactions, as well as the characteristics of safe use that require the cooperation of anesthesiologists, cause medical staff and patients in the burn department in my country to worry and worry about its use; ②The burn department lacks specialized anesthesiologists and ventilators;③ At present, there are no guidelines and rules for the management of burn pain in China, so that the treatment methods of burn doctors for dressing change operation pain are determined by personal experience and preference, resulting in almost zero analgesia for burn operation pain, especially for children and the elderly.
④Burn doctors are busy with their work and change the dressings of patients during surgery intervals, so there is no guarantee that the opioid painkillers will be changed after they take effect (20 minutes)
However, morphine analgesics cannot be used on burn patients because of their inhibitory effect on respiration;

Method used

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  • Pharmaceutical composition for easing pain and preparation method thereof
  • Pharmaceutical composition for easing pain and preparation method thereof
  • Pharmaceutical composition for easing pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 pearl lotus extract

[0019] Clean and dry 1 kg of pearl lotus dry product, pulverize it with a FW135 type traditional Chinese medicine pulverizer, place it in an extraction device with a round bottom flask, and successively use 95% (v / v) ethanol 8 L for reflux extraction for 2 hours, filter, Obtain the alcohol extract, repeat twice, combine the alcohol extract, concentrate to dryness under reduced pressure to obtain a crude extract, dissolve it into a suspension with 3L of pure water, and extract twice with 3L of ethyl acetate to obtain an ethyl acetate extract and water raffinate were concentrated under reduced pressure to form a thick paste, freeze-dried, pulverized into fine powder, and passed through a 100-mesh sieve to obtain the extract of ethyl acetate part and water part of Pearl Lotus.

Embodiment 2

[0020] Example 2 Study on the analgesic effect of pearl lotus extract on hot plate-induced pain

[0021] Take healthy female Kunming mice, place them on a hot plate (55±0.5)°C in turn, observe and record the time (s) from putting them on the hot plate to licking their hind paws, and set the time for licking their hind paws to 30s or Leapers are discarded. 40 female mice that passed the screening were selected, and the pain threshold was re-measured once after an interval of 5 minutes, and the average value of the data measured twice was used as the pain threshold before administration. According to the pain threshold before administration, it was randomly divided into the following four groups: blank control group (blank group), positive control group (positive group), pearl lotus ethyl acetate part extract group (ethyl ester group), pearl lotus water part extract group (water extraction group), 10 rats in each group. Based on the body weight of the mice, each group was give...

Embodiment 3

[0031] Example 3 Study on the inhibitory effect of pearl lotus extract on pain induced by acetic acid

[0032] Take 40 healthy Kunming mice and randomly divide them into the following four groups: blank control group (blank group), positive control group (positive group), pearl lotus ethyl acetate part extract group (ethyl ester group), pearl lotus water part In the extract group (water extraction group), each group was divided into male and female, with 10 rats in each group. Based on the body weight of the mice, each group was given the corresponding test substance in the following doses:

[0033] Blank group: normal saline 0.15mL / 10g;

[0034] Positive group: aspirin 0.2g / kg;

[0035] Ethyl group: 600 mg / kg of the dry powder of the extract of the part of the pearl lotus ethyl acetate prepared in Example 1;

[0036] Water extraction group: 600mg / kg of dry powder of pearl lotus water part extract prepared in Example 1;

[0037] Each group was intragastrically administered...

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Abstract

The invention discloses a pharmaceutical composition for easing pain and a preparation method of the pharmaceutical composition. The active ingredient of the pharmaceutical composition comprises water extract of Thalictrum trichopus Franch, wherein Thalictrum trichopus Franch refers to dried roots of plant in ranunculaceae thalictrum. The pharmaceutical composition can take pain easing effect quickly and hardly causes side effect; patients can take the pharmaceutical composition under the simple guidance of medical personnel; the pain easing effect fast disappear after drug withdrawal, and therefore the disease syndromes cannot be covered; and the pharmaceutical composition can be used for easing clinical acute pain, cancer pain and pre-hospital care pain of the children and adults.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and in particular relates to a pharmaceutical composition for analgesia and a preparation method thereof. Background technique [0002] Pain is associated with actual or potential injury and tissue damage from mechanical or other stimuli. Analgesia should run through the three stages of pre-hospital, emergency and post-hospital treatment. However, most medical staff focus on the pain control of inpatients, and pre-hospital and emergency analgesia are still weak links in pain management. For example, burn patients have to endure wound background pain, manipulation pain and burst pain. Procedural pain refers to the pain experienced by patients during or after wound management, including splint removal, dressing changes, debridement, laceration suturing, escharotomy for deflaking, passive joint motion, implantation and filling of skin expanders and other treatments...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P29/00A61K125/00
Inventor 赵明强冯军杰刘宗江
Owner 赵明强
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