Novel application of imatinib and derivative thereof to preparation of drugs for treating drug addiction

A technology of imatinib and imatinib mesylate, which is applied in the field of new uses of imatinib and its derivatives in the preparation of drugs for the treatment of drug addiction, and can solve the lack of drugs and solutions for drug addiction treatment, etc. problem, to achieve the effect of good bioavailability, high water solubility and cost saving

Active Publication Date: 2016-11-09
安徽安迪克莱斯医药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is still a lack of effective drugs and programs for drug addiction treatment, and it is...

Method used

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  • Novel application of imatinib and derivative thereof to preparation of drugs for treating drug addiction
  • Novel application of imatinib and derivative thereof to preparation of drugs for treating drug addiction
  • Novel application of imatinib and derivative thereof to preparation of drugs for treating drug addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] [Implementation 1] The effect of imatinib on the formation of morphine sensitization in rats

[0042] In this example, imatinib is selected as the anti-morphine-addicted high-incidence activity drug, and by establishing a morphine-sensitized rat model, the improvement effect of imatinib on the high-incidence spontaneous activity caused by morphine in rats is investigated, aiming at Choose an anti-morphine addictive high-incidence locomotor drug with definite curative effect and low toxicity.

[0043] Materials and Methods

[0044] Drugs and reagents Morphine (Qinghai Pharmaceutical Factory); Imatinib (Novartis PharmaStein AG)

[0045]Animal SPF grade male SD rats, weighing 220-250g. Provided by the Hubei Laboratory Animal Research Center, the animal certificate number is NO.42000600012016, and the production license number is SCXK (E) 2015-2018. Rat feed was purchased from the Experimental Animal Center of Wuhan University.

[0046] experimental method

[0047] Gro...

Embodiment 2

[0056] [Example 2] Effect of imatinib on psychological craving after morphine addiction in rats

[0057] In this example, imatinib was selected as the anti-psychological craving drug for morphine addiction, and a morphine conditioned place preference (conditioned place preference, CPP) model was established to study the effect of imatinib on the psychological craving for morphine addiction induced by environmental cues. The purpose of this study is to select a drug with definite curative effect and low toxicity to treat drug addiction and prevent relapse.

[0058] Materials and Methods

[0059] Drugs and reagents Morphine (Qinghai Pharmaceutical Factory); Imatinib (Novartis PharmaStein AG)

[0060] Animal SPF grade male SD rats, weighing 220-250g. Provided by the Hubei Laboratory Animal Research Center, the animal certificate number is NO.42000600012016, and the production license number is SCXK (E) 2015-2018. Rat feed was purchased from the Experimental Animal Center of Wu...

Embodiment 3

[0083] [Example 3] Effects of imatinib derivatives (imatinib mesylate) on the formation of morphine sensitization in rats

[0084] In this example, imatinib derivatives were selected as drugs against morphine-addicted high-incidence activities, and by establishing a morphine-sensitized rat model, the improvement of imatinib derivatives on rat morphine-induced high-incidence spontaneous activities was explored. The purpose of this study is to select a drug with definite curative effect and low toxicity against high incidence of locomotor activity in morphine addiction.

[0085] Materials and Methods

[0086] Drugs and Reagents Morphine (Qinghai Pharmaceutical Factory); Imatinib Mesylate (Novartis PharmaSteinAG)

[0087] Animal SPF grade male SD rats, weighing 220-250g. Provided by the Hubei Laboratory Animal Research Center, the animal certificate number is NO.42000600012016, and the production license number is SCXK (E) 2015-2018. Rat feed was purchased from the Experimenta...

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Abstract

The invention discloses novel application of imatinib and a derivative thereof and provides novel application of imatinib and the derivative thereof to preparation of drugs for preventing and/or treating drug addiction and preparation of drugs for preventing and/or treating relapse after drug withdrawal. According to the novel application, a classic rat sensitization and conditioned place preference animal model for evaluating addiction is adopted, the influences of imatinib and the derivative methanesulfonic acid imatinib on expression of the recrudescence behavior and sensitization behavior appearing after withdrawal of the conditioned place preference of a rat is formed are observed respectively, and the result indicates that imatinib and the derivative methanesulfonic acid imatinib have an inhibitory effect on morphine addiction and have the effect of preventing relapse after withdrawal of morphine addiction.

Description

technical field [0001] The present invention relates to a new application of imatinib and its derivatives, in particular to the application of imatinib and its derivatives in the preparation of drugs for treating drug addiction. Background technique [0002] Drug addiction is a chronic relapsing brain disease characterized by loss of control and compulsive drug use behaviors. It is difficult to completely implement detoxification and relapse, which is the difficulty of detoxification treatment. The international anti-drug convention divides the drugs of dependence into three categories: narcotic drugs, psychotropic drugs and others. Among them, narcotic drugs are divided into opioids, cocaine, cannabis, etc.; psychotropic drugs are divided into sedative hypnotics and anxiolytics such as barbiturates, central stimulants such as amphetamines, hallucinogens such as ergot diethylamine, etc.; It also includes alcohol, tobacco and volatile organic solvents. Drug addiction has b...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61P25/30A61P25/32A61P25/34
CPCA61K31/506
Inventor 李艳琴陈萍萍杨奇
Owner 安徽安迪克莱斯医药有限责任公司
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