This invention relates to ophthalmic compositions comprising
troxerutin and a surfactant selected from polyoxyethylene 35
castor oil, polyoxyethylene 40 hydrogenated
castor oil, polyoxyethylene (20)
sorbitan monooleate, polyoxyethylene (20)
sorbitan monolaurate, and mixtures thereof, wherein the weight ratio of
troxerutin to the surfactant is from 0.02:1 to 100:1, wherein the surfactant is present in an amount of up to 7% by weight relative to the total weight of the composition, and wherein the composition is in the form of a solution, suspension, or gel. The invention also relates to the compositions for treating dry
eye disease.