Cefadroxil dry suspension and preparing method

A technology of dry cefadroxil and cefadroxil, applied in the field of medicine, can solve the problems of slow drug effect, unpleasantness, low bioavailability, etc., and achieve the effects of strong patient compliance, reducing local irritation, and improving solubility

Active Publication Date: 2005-10-19
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because cefadroxil has an unpleasant special smell, it is difficult for patients to take it due to the smell when it is made into granules, especially for children and the elderly.
At the same time, cefadroxil granules are easy to absorb moisture, have poor stability and are insoluble in water, so they are made into granules, which have the disadvantages of loss of content and low bioavailability during brewing
However, the tablet and capsule dosage forms need to disintegrate after taking, and the drug effect is slow
In summary, the existing dosage forms of cefadroxil cannot meet the clinical needs, and there is an urgent need to develop more advanced dosage forms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Component Weight

[0041] Main drug Cefadroxil 100g

[0042] Inclusion agent Cyclodextrin 48g

[0043] Water soluble filler Sucrose 240g

[0044] Mannitol 240g

[0045] Disintegrant sodium starch glycolate 64g

[0046] Suspending agent xanthan gum 8g

[0047] Flavoring agent sodium saccharin 0.32g

[0048] Pineapple essence 4.8g

[0049] Colorant Gardenia Yellow 0.24g

[0050] Adhesive 60% ethanol 40ml

[0051] Grind cefadroxil, β-cyclodextrin and water efficiently and quickly for 1 hour, dry in vacuum at 40°C, pulverize, and pass through a 120-mesh sieve; water-soluble filler, disintegrating agent, and suspending agent are respectively passed through a 100-mesh sieve for later use. Take cefadroxil, sucrose, mannitol, carboxymethyl starch sodium, and xanthan gum according to the prescription amount and mix, stir for more than 30 minutes, and mix well. Sodium saccharin, pineapple essence ...

Embodiment 2

[0053] Component Weight

[0054] Main drug Cefadroxil 90g

[0055] Inclusion agent Hydroxypropyl β-cyclodextrin 35g

[0056] Water soluble filler Sucrose 220g

[0057] Xylitol 220g

[0058] Disintegrant sodium starch glycolate 57g

[0059] Suspending agent polyvinylpyrrolidone 7.6g

[0060] Adhesive 60% ethanol 35ml

[0061] Grind cefadroxil, β-cyclodextrin and water efficiently and quickly for 1 hour, dry in vacuum at 40°C, pulverize, and pass through a 120-mesh sieve; water-soluble filler, disintegrating agent, and suspending agent are respectively passed through a 100-mesh sieve for later use. Take cefadroxil, sucrose, xylitol, sodium starch glycolate, and polyvinylpyrrolidone according to the prescription amount and mix, stir for more than 30 minutes, and mix well. 60% ethanol is stirred and added to the above-mentioned mixed main and auxiliary materials to obtain a soft material; granulated with a 20-mesh sieve, dried at...

Embodiment 3

[0063] Component Weight

[0064] Main drug Cefadroxil 80g

[0065] Inclusion agent Hydroxypropyl β-cyclodextrin 27g

[0066] Water Soluble Bulking Agent Xylitol 250g

[0067] Mannitol 250g

[0068] Disintegrant sodium starch glycolate 58g

[0069] Suspending agent peach gum 6.6g

[0070] Adhesive 10% polyvinylpyrrolidone ethanol solution 32ml

[0071] Sieve the raw and auxiliary materials separately, cefadroxil through a 120-mesh sieve; mannitol, xylitol, carboxymethyl starch sodium, and peach gum respectively pass through a 100-mesh sieve, and set aside. Take cefadroxil, mannitol, xylitol, carboxymethyl starch sodium, and peach gum according to the prescription amount and mix, stir for more than 30 minutes, and mix well. 10% polyvinylpyrrolidone ethanol solution is stirred and added to the above-mentioned mixed main and auxiliary materials to obtain a soft material. Granulate with 20-mesh sieve, dry at 55-60°C; granulate wi...

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PUM

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Abstract

The present invention relates to dry cefadroxil suspension and its preparation process, belongs to the field of medicine technology, and is for raising the water solubility and bioavailability of cefadroxil. The dry cefadroxil suspension consists of cefadroxil and supplementary material comprising including agent, water soluble stuffing, distintegrating agent, suspension assistant and adhesive. The dry cefadroxil suspension has the features of high medicine solubility, high medicine bioavailability, high chemical stability, good taste, convenient taking, high patient's compliance, full absorption in gastrointestinal tract, less irritation to gastrointestinal tract of medicine, etc.

Description

technical field [0001] The invention relates to an antibiotic oral preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Cefadroxil is a first-generation oral cephalosporin that is a broad-spectrum antibiotic. It has high antibacterial activity against Staphylococcus aureus, various streptococci and anaerobic cocci, and has a strong effect on some enterobacteriaceae. Its bactericidal mechanism of action is achieved by inhibiting the formation of bacterial cell walls. This product has low toxicity, good absorption, long-lasting antibacterial effect and long action time. It is mainly used to treat respiratory tract infection, genitourinary tract infection, skin and soft tissue infection, digestive tract infection, etc., with remarkable curative effect and few and mild adverse reactions, mostly gastrointestinal reactions. Cefadroxil is widely used at home and abroad, and has been approved for marketing in ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/16A61K31/545A61P31/04
Inventor 高志峰齐新英郭卫芹智彩辉杨亚青韩卫占
Owner CSPC OUYI PHARM CO LTD
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