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Preparing method of triptolide molecule microcapsule

A technology of triptolide and propylene glycol is applied in the directions of microcapsules, non-active components of polymer compounds, capsule delivery, etc., which can solve the problems of gastrointestinal irritation, toxic and side effects, discomfort, etc., and reduce drug irritation and Toxic and side effects, improving drug bioavailability and regulating drug release rate

Inactive Publication Date: 2007-08-15
福建省医学科学研究所
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Problems solved by technology

However, currently applicable triptolide preparations have severe toxic and side effects, and the main problems include: (1) intravenous injection of triptolide injections is easy to cause venous ulceration, which is difficult for patients to accept; (2) other oral preparations are harmful to the gastrointestinal tract irritating, causing discomfort

Method used

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  • Preparing method of triptolide molecule microcapsule

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Embodiment Construction

[0009] Weigh 0.40g of β-cyclodextrin and dissolve it in double-distilled water, keep the temperature in a water bath at 50°C, and set the volume to 10ml to prepare a saturated solution of β-CD. Accurately weigh 2 mg of triptolide, add 200 μL of 1,2-propanediol, add 472 μL of β-CD saturated solution after ultrasonication and heating, ultrasonication at 50°C for 20 minutes, refrigerate overnight, place on a microporous membrane filter, Buchner funnel Suction filtration, wash the clathrate several times with an appropriate amount of acetone, evaporate the acetone to dryness, and dry at 80°C to obtain a dry clathrate in the form of white powder.

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Abstract

This invention relates to a method for preparing triptolide / beta-cyclodextrin inclusion compound, which is characterized in preparing according to the follow steps: (1) dissolving beta-cyclodextrin dissolve in double distilled water, placing in water bath with constant temperature, and making to beta-CD saturated solution; (2) dissolving triptolide in 1,2-propylene glycol, treating with ultrasound, adding beta-CD at a mol ratio of 1:2-4, heat dissolving with ultrasound, cooling for a night; and (3) placing on the millipore filter, air pump filtrating with Buchner funnel, washing with acetone, and drying to obtain white powdered form inclusion compound. The product of the invention can maintain the original property and efftect of triptolide, reduce local excitation and toxico-adverse side effect of triptolide, thereby improving pharmic security.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparation, in particular to a process for preparing β-cyclodextrin-included triptolide molecular microcapsules by using an ultrasonic thermal melting method. Background technique [0002] Triptolide (also known as triptolide) is an epoxy diterpene lactone extracted from the root bark of Tripterygium genus Tripterygium in the family Euonymus, in the form of colorless columnar crystals, odorless, and difficult to dissolve. It has a significant function of suppressing immune response, has a strong anti-graft rejection effect, and can also be used to treat rheumatoid arthritis, systemic lupus erythematosus and psoriasis and other skin diseases, leprosy, etc., and has anti-cancer and anti-AIDS virus etc. However, currently applicable triptolide preparations have severe toxic and side effects, and the main problems include: (1) intravenous injection of triptolide injections is easy to caus...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/50A61K47/40A61P37/06A61P37/02A61P29/00A61P19/02A61P17/06A61P35/00A61P31/18A61P31/12
Inventor 林建峰
Owner 福建省医学科学研究所