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Compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and preparation method thereof

A technology of sodium selenite and vitamins, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. Unable to prepare nanoemulsion and other problems, to achieve the effect of easy mass production, reducing local irritation and improving bioavailability

Inactive Publication Date: 2011-03-02
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this product can not be directly used for animals, 1, this preparation is owing to technical limitation, can only prepare the nanoemulsion of the low content (vitamin E content below 5%) suitable for human use according to this method, can't prepare the nanoemulsion suitable for animal use. Nanoemulsion that is still stable under high content conditions (vitamin E content between 5% and 10%); 2. The preparation is a unilateral preparation of vitamin E, which belongs to human medicine, does not meet the relevant regulations of the Ministry of Agriculture, and cannot be used for livestock and poultry use, its scope of application is limited; 3. The route of injection administration is not suitable for the market requirements under the current large-scale intensive breeding conditions
[0007] So far, no technology disclosure about sodium selenite-vitamin E compound oral nanoemulsion has been found in the field of veterinary medicine

Method used

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  • Compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and preparation method thereof
  • Compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and preparation method thereof
  • Compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1 contains the sodium selenite-vitamin E nanoemulsion preparation of 10% vitamin E

[0057] This sodium selenite-vitamin E nanoemulsion comprises each component (in 100ml) of following content: the vitamin E of 10g, the sodium selenite of 0.1g, the emulsifier of 30g, the auxiliary emulsifier of 15g, the co-emulsifier of 0.1g Antioxidant and antiseptic (antioxidant: antiseptic = 1: 1 mass ratio), add purified water to 100ml.

[0058] The emulsifier is Tween-80, the co-emulsifier is absolute ethanol, the antioxidant is 2,6-dibutylhydroxytoluene, and the preservative is ethylparaben.

[0059] Preparation:

[0060] Mix vitamin E, emulsifier and co-emulsifier, and stir evenly to make a mixed solution; put preservatives and antioxidants into the mixed solution, and stir until completely dissolved to obtain a mixed solution ①; weigh the sodium selenite solution In purified water, make a mixed solution ② for later use; slowly add the mixed solution ② to the mixed s...

Embodiment 2

[0093] Embodiment 2 contains the sodium selenite-vitamin E nanoemulsion preparation of 8% vitamin E

[0094] This sodium selenite-vitamin E nanoemulsion comprises each component (in 100ml) of following content: the vitamin E of 8g, the sodium selenite of 0.1g, the emulsifier of 18g, the assistant emulsifier of 9g, the co-emulsifier of 0.1g Antioxidant and antiseptic (antioxidant: antiseptic = 1: 1 mass ratio), add purified water to 100ml. The preparation method is the same as in Example 1.

[0095] The emulsifier is polyoxyethylene castor oil EL-40, the co-emulsifier is isopropanol, the antioxidant is 2,6-dibutylhydroxytoluene, and the preservative is ethylparaben.

Embodiment 3

[0096] Example 3 Sodium Selenite-Vitamin E Nanoemulsion Containing 5% Vitamin E

[0097] This sodium selenite-vitamin E nanoemulsion comprises each component (in 100ml) of following content: the vitamin E of 5g, the sodium selenite of 0.1g, the emulsifier of 15g, the auxiliary emulsifier of 7.5g, 0.1g Antioxidant and antiseptic (antioxidant: antiseptic=1: 1 mass ratio), add purified water to 100ml. The preparation method is the same as in Example 1.

[0098] The emulsifier is Tween-80, the co-emulsifier is absolute ethanol, the antioxidant is 2,6-dibutylhydroxytoluene, and the preservative is ethylparaben.

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Abstract

The invention relates to a compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and a preparation method thereof. The compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock is prepared from the following raw materials by mass volume percent: 5 to 10% of vitamin E, 15 to 35% of emulsifier, 7.5 to 17.5% of auxiliary emulsifier, 0.1% of sodium selenite, 0.1% of antioxidant and preservative and the balance solvent. The sodium selenite-vitamin E nano-emulsion of the invention is clear and bright emulsion which consists of self-emulsified nano-particles and is a self-emulsified clear and transparent thermodynamically stable system; and the production process is simple and facilitates mass production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a compound sodium selenite-vitamin E oral nanoemulsion preparation for veterinary use and a preparation method thereof. Background technique [0002] Selenium is a mineral trace element and a component of glutathione peroxidase. This enzyme can decompose intracellular peroxide, prevent the oxidative damage reaction of the cell membrane, and protect the biofilm from damage. It is usually stored in the human body Or animal hemoglobin and organs. Modern science shows that supplementing selenium to animals can improve the animal body's antibody titer to sheep red blood cell (SRBC) antigen or tetanus toxin, and improve its own immunity. Conversely, when animals are deficient in selenium, the humoral immune response decreases, including decreased antibody titer and immune response time delay, which affects the body's metabolism of amino acids, protein synthesis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61K47/44A61K47/34A61K9/107A61P3/02A61P15/00A61P31/04A61P17/02A61K31/355A61K47/10A61K47/26
Inventor 李成应刘金亮王雅琪崔进吴连勇田玉柱
Owner QILU ANIMAL HEALTH PROD
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