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Spaston orally disintegrating tablets and preparation thereof

The technology of oral disintegrating tablet and phloroglucinol is applied in directions such as pharmaceutical formulations, medical preparations of inactive ingredients, and pill delivery, which can solve problems such as poor dissolution effect, achieve fast onset of effect, fast absorption, and reduce local stimulating effect

Inactive Publication Date: 2008-07-02
HAINAN JINRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dissolution effect is poor
[0010] At present, there is no relevant literature report on the preparation of phloroglucinol orally disintegrating tablets by powder compression method or wet granulation method at home and abroad

Method used

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  • Spaston orally disintegrating tablets and preparation thereof
  • Spaston orally disintegrating tablets and preparation thereof
  • Spaston orally disintegrating tablets and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Preparation of orally disintegrating tablet of the present invention

[0035] 1. Prescription

[0036] 1. Raw material - Phloroglucinol dihydrate 80.0g

[0037] 2. Filling agent - mannitol 20.0g

[0038] 3. Disintegrant—cross-linked polyvinylpyrrolidone (PVPP) 30.0g

[0039] Microcrystalline cellulose 20.0g

[0040] 4. Lubricant—magnesium stearate 0.75g

[0041] A total of 1000 tablets were prepared, specification: 80.0mg (calculated as phloroglucinol dihydrate)

[0042] 2. Preparation method

[0043] Step 1: Pass phloroglucinol dihydrate and auxiliary materials through a 100-mesh sieve respectively, and take by weight.

[0044] The second step: get the cross-linked polyvinylpyrrolidone (PVPP) of phloroglucinol dihydrate, mannitol, microcrystalline cellulose and 2 / 3 recipe quantity, mix well, add 50% ethanol (V / V) aqueous solution preparation Soft material, pass through 20 mesh sieve to granulate, dry at 50℃ for 4 hours, and granulate.

[0045] Step...

Embodiment 2

[0050] Example 2 Preparation of orally disintegrating tablet of the present invention

[0051] 1. Prescription

[0052] 1. Raw material - Phloroglucinol dihydrate 80.0g

[0053] 2. Filling agent - mannitol 14.0g

[0054] 3. Disintegrating agent - cross-linked polyvinylpyrrolidone (PVPP) 25.0g

[0055]Microcrystalline cellulose 14.0g

[0056] 4. Lubricant - Micropowder silica gel 2.0g

[0057] Talc powder 2.0g

[0058] 5. Flavoring agent - sucralose 1.0g

[0059] A total of 1000 tablets were prepared, specification: 80.0mg (calculated as phloroglucinol dihydrate)

[0060] 2. Preparation method

[0061] Step 1: Pass phloroglucinol dihydrate and auxiliary materials through a 100-mesh sieve respectively, and take by weight.

[0062] The second step: get phloroglucinol dihydrate, mannitol, sucralose and 60% prescription amount of cross-linked polyvinylpyrrolidone (PVPP) and 60% prescription amount of microcrystalline cellulose, mix well, add 50% Soft materials made from et...

Embodiment 3

[0068] Embodiment 3 Preparation of orally disintegrating tablet of the present invention

[0069] 1. Prescription

[0070] 1. Raw material - Phloroglucinol dihydrate 80.0g

[0071] 2. Filling agent - mannitol 20.0g

[0072] 3. Disintegrating agent - cross-linked polyvinylpyrrolidone (PVPP) 20.0g

[0073] Microcrystalline cellulose 15.0g

[0074] 4. Lubricant - Micropowder silica gel 2.0g

[0075] Talc powder 2.0g

[0076] 5. Flavoring agent - sucralose 1.0g

[0077] A total of 1000 tablets were prepared, specification: 80.0mg (calculated as phloroglucinol dihydrate)

[0078] 2. Preparation method

[0079] Step 1: Pass phloroglucinol dihydrate and auxiliary materials through a 100-mesh sieve respectively, and take by weight.

[0080] The second step: get phloroglucinol dihydrate, mannitol, sucralose and 60% prescription amount of cross-linked polyvinylpyrrolidone (PVPP) and 60% prescription amount of microcrystalline cellulose, mix well, add 50% Soft materials made fro...

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PUM

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Abstract

The invention provides a phloroglucinol oral disintegrating tablet, which takes the phloroglucinol as the active ingredient, and disintegrating agents, fillers, lubricants, flavoring agents, binding agents and effervescent agents are added for preparation. The invention further provides a preparation method of the phloroglucinol oral disintegrating tablet. The phloroglucinol oral disintegrating tablet of the invention not only has the rapid disintegration, good taste and no sense of gravel, but can also can be taken under the condition of no water and have the rapid action and more convenient taking, so the invention can improve the compliance of the patients and the efficacy of the drug and other features of the orally disintegrating tablet, at the same time, the invention has light tablet weight, small volume, no powder falling, good brittleness and better dissolution effect than the freeze-dried orally disintegrating tablet. The production cost is low, the dissolution is faster, the invention is more beneficial to the absorption, and the invention can play the effect of pain reliving faster. The invention has the advantage that the invention can carry out the preparation by only adopting the ordinary pressing equipments and the simple technique without the need of special production equipments and conditions.

Description

technical field [0001] The invention relates to a phloroglucinol orally disintegrating tablet, which belongs to the field of medicines. Background technique [0002] Phloroglucinol belongs to a new type of antispasmodic analgesic, it can directly act on the smooth muscle of gastrointestinal tract and genitourinary tract spasm, and is a myogenic, non-atropine, non-opapaverine smooth muscle antispasmodic. Compared with other antispasmodics for smooth muscle, it is characterized by no anticholinergic effect. While relieving smooth muscle spasm, it will not produce a series of anticholinergic side effects, and will not cause symptoms such as hypotension, increased heart rate, and arrhythmia. , had no effect on cardiovascular function. Animal pharmacological tests show that it only acts on spastic smooth muscle and has little effect on normal smooth muscle. Studies have shown that phloroglucinol has a good effect on various above-mentioned abdominal pains, and the degree of abd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K9/20A61K47/02A61K47/12A61K47/18A61K47/32A61K47/34A61K47/36A61K47/38A61P29/02A61P1/00A61P13/00A61K47/10A61K47/14A61K47/26
Inventor 王小树杨贵方
Owner HAINAN JINRUI PHARMA
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