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Glipizide tablets and preparation method thereof

A technology of glipizide tablets and parts by weight, applied in the field of medicine, can solve problems such as failure to provide, high production cost, complicated process parameters, etc., and achieve the effects of easy implementation, stable release and simple process

Active Publication Date: 2015-10-28
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Invention patent CN 104434856 A discloses a method for preparing controlled-release tablets floating in the stomach. Although this invention solves the problem of the residence time of glipizide controlled-release tablets in the gastrointestinal tract, it does not require a laser punching machine for laser drilling. However, the controlled-release layer coating is required in the production process, and the process parameters of the coating process are relatively complicated. The coating material contains expensive excipients such as ethyl cellulose, and the production cost is relatively high.
And in the prior art, all fail to provide a kind of dissolution rate high, the preparation method of the glipizide tablet that drug release is stable, and preparation process is simple

Method used

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  • Glipizide tablets and preparation method thereof
  • Glipizide tablets and preparation method thereof
  • Glipizide tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The glipizide is crushed through a 100-mesh sieve, and the filler is crushed through a 100-mesh sieve. Weigh 50 g of glipizide and 1750 g of filler, add them into a wet granulator, and mix well. Add 400 g of absolute ethanol and 400 g of purified water to prepare a soft material, and granulate with a 20-mesh sieve. The wet granules are dried with a fluidized granulation dryer, and the granules are sized with a 20-mesh screen of a crushing and sizing machine. Add 1800 g of the granules, 100 g of the disintegrant low-substituted hydroxypropyl cellulose and 10 g of the lubricant magnesium stearate into the mixer, and mix for 10 minutes. The mixed powder is compressed into tablets with a rotary tablet machine.

Embodiment 2-3

[0039] The glipizide is crushed through a 100-mesh sieve, and the filler is crushed through a 100-mesh sieve. Weigh 50 g of glipizide, 450 g of starch, 300 g of mannitol, 550 g of sucrose, and 450 g of microcrystalline cellulose, add them into a wet granulator, and mix well. Add 400 g of absolute ethanol and 400 g of purified water to prepare a soft material, and granulate with a 20-mesh sieve. The wet granules are dried with a fluidized granulation dryer, and the granules are sized with a 20-mesh screen of a crushing and sizing machine. Add 1800 g of granules, 10 g of disintegrant and lubricant magnesium stearate into the mixer, and mix for 10 minutes. The mixed powder is compressed into tablets with a rotary tablet machine.

Embodiment 4-5

[0047] The glipizide is crushed through a 100-mesh sieve, and the filler is crushed through a 100-mesh sieve. Weigh 50 g of glipizide, 450 g of starch, 300 g of mannitol, 550 g of sucrose, and 450 g of microcrystalline cellulose, add them into a wet granulator, and mix well. Add binder to prepare soft material, granulate with 20 mesh sieve. The wet granules are dried with a fluidized granulation dryer, and the granules are sized with a 20-mesh screen of a crushing and sizing machine. Add 1800 g of the granules, 100 g of the disintegrant low-substituted hydroxypropyl cellulose and 10 g of the lubricant magnesium stearate into the mixer, and mix for 10 minutes. The mixed powder is compressed into tablets with a rotary tablet machine.

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Abstract

The invention belongs to the field of medicines and particularly relates to glipizide tablets and a preparation method thereof. The glipizide tablets comprise raw materials in parts by weight as follows: 4-6 parts of glipizide, 87-263 parts of a filler, 5-15 parts of a disintegrating agent and 0.5-1.5 parts of a lubricant, wherein the filler preferably comprises components in parts by weight as follows: 24-72 parts of starch, 15-45 parts of mannitol, 26-78 parts of sugar and 22-68 parts of microcrystalline cellulose. The glipizide tablets have stable drug release property and high dissolution rate. The invention further provides the preparation method of the glipizide tablets. The preparation method has a simple and reasonable process and is easy to implement.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a glipizide tablet and a preparation method thereof. Background technique [0002] Glipizide is an oral hypoglycemic drug of the sulfonamide class, which achieves its rapid hypoglycemic effect by stimulating the pancreas to secrete insulin. The effect depends on the function of pancreatic β cells, and extrapancreatic effects should also play a part in the mechanism of action of sulfonylurea oral hypoglycemic drugs. The extrapancreatic effects of increasing insulin sensitivity and reducing hepatic glucose production are important in the mechanism of action of glipizide. Glipizide currently on the market has various specifications such as 2.5mg, 5mg and 10mg, and its dosage forms include tablets, dispersible tablets, capsules, controlled-release tablets, orally disintegrating tablets, etc. [0003] After taking Glipizide Tablets, the blood sugar fluctuates greatly, and hypogly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/36A61K47/10A61K47/26A61K47/38A61K31/64A61P3/10
Inventor 赵玉山黄京山李伟杨金成邵伟
Owner REYOUNG PHARMA
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