A composition for controlling diabetes and its relevant diseases comprising complications and the like is composed of ginsenoside, ginseng polysaccharides, mulberry leaf flavones, lotus leaf alkaloids, chicoric acid and licorice prenylflavonoid, and the synergistic effect of all components in the above six raw materials is utilized to prepare an oral preparation, such as a granule, a hard capsule, a soft capsule, a tablet, a powder, a pill, a bag tea or an oral liquid. The composition can be used for preparing foods, healthcare foods or medicines, and can control the diabetes and concurrent heart and cerebral vessel diseases.