Novel method for treating diabetes
a technology for diabetes and mellitus, applied in the field of new diabetes mellitus treatment methods, can solve the problems of serious diabetic complications, serious human health harm, and impact on the quality of life of patients, and achieve the effects of promoting repair of pancreatic islet cell injuries
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example 1
en Lowers Blood Glucose in Diabetic Mice
[0224]Eight 24- to 25-week-old male db / db mice were randomly divided into two groups, a group of 5 mice administered with plasminogen, and a control group of 3 mice administered with vehicle PBS. The mice were weighed and grouped on the day the experiment started, i.e. day 0. Plasminogen or PBS was administered starting from day 1. The mice in the group administered with plasminogen were injected with human plasminogen at a dose of 2 mg / 0.2 mL / mouse / day via the tail vein, and the mice in the control group administered with vehicle PBS were injected with an equal volume of PBS via the tail vein, both lasting for 31 consecutive days. After fasting for 16 hours on days 10 and 31, blood glucose testing was carried out using a blood glucose test paper (Roche, Mannheim, Germany).
[0225]The results show that the blood glucose level in mice in the group administered with plasminogen was remarkably lower than that in the control group administered with ...
example 2
en Lowers Fructosamine Level in Diabetic Mice
[0226]For five 24- to 25-week-old male db / db mice, 50 l of blood was collected from venous plexus in the eyeballs of each mouse one day before administration, recorded as day 0, for detecting a concentration of serum fructosamine; and starting from day 1, plasminogen is administered for 31 consecutive days. On day 32, blood was taken from the removed eyeballs to detect the concentration of serum fructosamine. The concentration of fructosamine was measured using a fructosamine detection kit (A037-2, Nanjing Jiancheng).
[0227]The concentration of fructosamine reflects the average level of blood glucose within 1 to 3 weeks. The results show that the concentration of serum fructosamine is remarkably decreased after administration of plasminogen, and as compared with that before administration, the statistical difference is extremely significant (FIG. 2). This indicates that plasminogen can effectively reduce blood glucose in diabetic animals.
example 3
en Lowers Glycated Hemoglobin Level in Diabetic Mice
[0228]Nine 26-week-old male db / db mice were weighed and then randomly divided, according to body weight, into two groups, a group of 4 mice administered with plasminogen and a control group of 5 mice administered with vehicle PBS, on the day the experiment started. Starting from day 1, plasminogen or PBS was administered. The mice in the group administered with plasminogen were injected with human plasminogen at a dose of 2 mg / 0.2 mL / mouse / day via the tail vein, and the mice in the control group administered with vehicle PBS were injected with an equal volume of PBS via the tail vein, both lasting for 35 consecutive days. On day 35, the mice were fasted for 16 hours, and on day 36, the blood was taken from removed eyeballs for detecting the concentration of plasma glycated hemoglobin.
[0229]The content of glycated hemoglobin can generally reflect the control of blood glucose in a patient within recent 8 to 12 weeks. The results show...
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