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Glipizide oral cavity disintegrating lyophilized tablets and method for preparing the same

A technology of glipizide and oral cavity is applied in the field of preparation of oral disintegrating tablets and glipizide oral disintegrating freeze-dried tablets, and achieves the effects of improving bioavailability, solving difficulty in taking medication, and improving medication compliance.

Inactive Publication Date: 2008-03-05
HAILING PHARMA PLANT HAINAN PROV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Neither capsules nor regular tablets do a good job of solving this problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0038] Example 1: Dissolve 2.5 g of glipizide, 1.5 g of xanthan gum, and 4 g of gelatin in 100 ml of water to form suspension A; dissolve 6 g of lactose, 8 g of mannitol, and 0.5 g of aspartame in 100 ml of water to form Solution B; Mix Suspension A and Solution B, add appropriate amount of water to dilute, and stir well. Put the above-mentioned mixed solution into a mold of the required specification, and then put it into a freezer to freeze rapidly at a temperature of -20°C to -30°C. Put the frozen charge mold in a freeze dryer, sublimate under vacuum and low temperature conditions, and remove moisture. Compressed film packaging: the tablets obtained after freeze-drying are compressed film packaged.

example 2

[0039] Example 2: Dissolve 2.5 g of glipizide, 1 g of xanthan gum, and 4.5 g of gelatin in 100 ml of water to form a suspension A; dissolve 8 g of lactose, 6 g of mannitol, and 0.5 g of aspartame in 100 ml of water to form Solution B; Mix Suspension A and Solution B, add appropriate amount of water to dilute, and stir well. Put the above-mentioned mixed solution into a mold of the required specification, and then put it into a freezer to freeze rapidly at a temperature of -20°C to -30°C. Put the frozen charge mold in a freeze dryer, sublimate under vacuum and low temperature conditions, and remove moisture. Compressed film packaging: the tablets obtained after freeze-drying are compressed film packaged.

example 3

[0040] Example 3: Dissolve 2.5 g of glipizide, 2 g of xanthan gum, and 4 g of gelatin in 100 ml of water to form a suspension A; dissolve 7 g of lactose, 7 g of mannitol, 0.4 g of aspartame, and 0.1 g of chocolate flavor in 100ml of water to form solution B; mix suspension A and solution B, add appropriate amount of water to dilute, and stir well. Put the above-mentioned mixed solution into a mold of the required specification, and then put it into a freezer to freeze rapidly at a temperature of -20°C to -30°C. Put the frozen charge mold in a freeze dryer, sublimate under vacuum and low temperature conditions, and remove moisture. Compressed film packaging: the tablets obtained after freeze-drying are compressed film packaged.

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PUM

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Abstract

The present invention relates to an oral disintegrant freeze-dried tablet which can be quickly disintegrated in the mouth cavity and absorbed for reducing blood sugar effectively. It is made up by using glipizide as main medicine, adding filling agent, adhesive and correctives and making them undergo the process of freeze-drying treatment.

Description

【Technical field】 [0001] The invention relates to a hypoglycemic orally disintegrating freeze-dried tablet that can be rapidly disintegrated and absorbed in the oral cavity. It mainly uses glipizide as the main agent, and adds appropriate fillers, adhesives and flavoring agents to make a solution , made into orally disintegrating tablets after freeze-drying. The invention also relates to a preparation method of the glipizide orally disintegrating freeze-dried tablet. 【Background technique】 [0002] Diabetes is mainly divided into two types: one is insulin-dependent, also known as type 1, with a more rapid onset, mostly seen in children and adolescents, genetic factors play an important role in the onset, and must rely on insulin treatment; the other is non-insulin-dependent Type 2, also known as type 2, is more common in middle-aged and elderly people, and its onset is slow. Although it also has a genetic tendency, the incidence is mainly related to environmental factors, a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4965A61P3/08
Inventor 张建强王小树
Owner HAILING PHARMA PLANT HAINAN PROV
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