Method for preparing high stripping-degree hautriwaic glipizide capsule

A technology for metformin glipizide hydrochloride capsules and metformin glipizide hydrochloride is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc. question

Inactive Publication Date: 2006-03-08
周卓和
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Chinese patent CN1617728A discloses a "medicine preparation and method for anti-diabetes", which discloses that the dosage ratio of metformin and glipizide is between 1000:1 and 100:1, and the technical problem to be solved is glipizide The problem of uniform content, for this reason, it is prepared by the method of double-layer tablet, or the method of injecting into

Method used

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  • Method for preparing high stripping-degree hautriwaic glipizide capsule

Examples

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Embodiment 1

[0034] Get metformin hydrochloride 250g and pass through a 100 mesh sieve, glipizide 2.5g pass through a 250 mesh sieve, then mix according to the method of equal increments, and mix with 15% povidone K 30 Ethanol solution is used as a binder to make soft materials, granulated with a 24-mesh sieve, dried in an oven at 50-60°C, granulated with a 20-mesh sieve, added with 1% magnesium stearate, and filled with No. 0 capsules after the content determination is qualified. get the product.

Embodiment 2

[0036] Get 250g of metformin hydrochloride and pass through a 100 mesh sieve, 2.5g of glipizide is micronized to make its fineness less than 200 mesh, then mix according to the equal increment method, and mix with 15% povidone K 30 Ethanol solution is used as a binder to make soft materials, granulated with a 24-mesh sieve, dried in an oven at 50-60°C, granulated with a 20-mesh sieve, added with 1% magnesium stearate, and filled with No. 0 capsules after the content determination is qualified. get the product.

Embodiment 3

[0038] Get metformin hydrochloride 350g to pass through 100 mesh sieves, glipizide 2.5g carry out micronization treatment, make its fineness be less than 200 mesh, then carry out mixing according to the method of increasing in equal quantity, with 15% povidone K 30 Ethanol solution is used as a binder to make soft materials, granulated with a 24-mesh sieve, dried in an oven at 50-60°C, granulated with a 20-mesh sieve, added with 1% magnesium stearate, and filled with No. 0 capsules after the content determination is qualified. get the product.

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Abstract

The preparation method of metformin hydrochloride glipizide capsule includes the following steps: using 250-500 weight portions of metformin hydrochloride, sieving it by using sieve with 100 meshes, using 2.5 weight portions of glipizide, sieving it by using sieve with 200 meshes or pulverizing it to make its fineness greater than 200 meshes, then uniformly mixing the above-mentioned materials, using dilute ethyl alcohol solution of polyvidone as adhesive, making soft material, granulating by using sieve with 24 meshes, drying at 50-60deg.C, finishing granules by using sieve with 20 meshes, adding 1% of magnesium stearate and capsulizing so as to obtain the invented finished product.

Description

technical field [0001] The invention relates to a preparation method of metformin hydrochloride glipizide capsules with high dissolution rate, belonging to the field of pharmaceutical preparations. Background technique [0002] Diabetes mellitus is a common disease that affects human health and life. It is a clinical syndrome caused by the interaction of genetic and environmental factors. Due to the absolute or relative lack of insulin secretion and the decrease in the sensitivity of target tissue cells to insulin, it causes diabetes. , protein, water and electrolytes and a series of metabolic disorders, with high blood sugar as the main common clinical sign. Prolonged illness can cause severe damage to multiple systems and be life-threatening. In the 1980s, there were 135 million patients in the world, including more than 10 million in my country. Epidemiological surveys have found that the prevalence of diabetes has been increasing year by year in recent years. It is esti...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61K9/48A61P3/10A61K31/155
Inventor 周卓和
Owner 周卓和
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