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Glipizide tablets for treating diabetes and preparation method thereof

A technology of glipizide tablets and glipizide, which is applied to chemical instruments and methods, metabolic diseases, mixers with rotating stirring devices, etc., can solve the problems of unsteady dissolution and other problems, and achieve simple structure, stable release, The effect of convenient operation

Inactive Publication Date: 2016-09-21
NANJING HUAKUANG INFORMATION CONSULTING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing glipizide tablets all adopt dry compression technology or use methods such as inclusion to increase the stability of the preparation, and the dissolution is unstable. Clinically, patients often have some side effects when taking it.

Method used

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  • Glipizide tablets for treating diabetes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 10g of glipizide, 30g of hydroxypropyl methylcellulose, 40g of calcium carbonate, 15g of L-aspartic acid, 15g of sodium alginate, 20g of calcium sulfate dihydrate, 10g of guar gum, and crospovidone Ketone 8g, magnesium stearate 1g.

[0018] Preparation process: put the glipizide raw material drug in a crushing equipment and pulverize it; mix the pulverized glipizide raw material drug and the above-mentioned excipients in a particle mixer according to the amount, granulate according to a conventional method, compress tablets, and pack to obtain finished product.

[0019] Particle mixers above, see figure 1 , comprising a stirring barrel 1, a stirring shaft 2 arranged in the stirring barrel 1 and a stirring motor 3 arranged on the stirring barrel 1 and connected with the stirring shaft 2, and the stirring shaft 2 is provided with a stirring The paddle 4 is provided with a through hole 5 on the stirring paddle 4, an annular groove 6 is provided on the inner wall of...

Embodiment 5

[0032] The release research of embodiment 5 glipizide tablet

[0033] Get respectively the tablet that the embodiment of the present invention 1, comparative example 2-4 prepare, according to the release assay method [2005 version 5 Chinese Pharmacopoeia (two) appendix XD first method], with 0.5% sodium lauryl sulfate 1000mL of the solution is used as the solvent, and the rotation speed is 50r / min. Operate according to the law. Take 10mL of the solution at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, and 24 hours, filter, and replenish the above Solvent 10mL; Get continued filtrate, according to spectrophotometry (2005 edition 5 Chinese Pharmacopoeia (two) appendix IVA) measure absorbance at 274nm wavelength place; Separately accurately weigh the glipizide reference substance amount of drying 2h through 105 degree, add 0.5% sodium dodecyl sulfate solution was heated and ultrasonically dissolved and diluted quantitatively to a solution containing 10ug of drug per 1mL. The absorbance...

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Abstract

The invention relates to glipizide tablets for treating diabetes, belonging to the technical field of Western medicine preparations. The glipizide tablets consist of the following components: 5-15 parts of glipizide, 20-40 parts of hydroxypropyl methyl cellulose, 30-50 parts of calcium carbonate and the like; and the components are mixed by a specific particle stirrer. The tablets provided by the invention are stably and slowly released.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a glipizide tablet for treating diabetes. Background technique [0002] Glipizide Tablets are suitable for patients with mild and moderate type II diabetes who are not satisfied with the curative effect of diet control and physical exercise for 2-3 months. The islet β cells of such diabetic patients need to have a certain function of secreting insulin, and there is no Acute complications (such as infection, trauma, ketoacidosis, hyperosmolar coma, etc.), not associated with pregnancy, no serious chronic complications. Existing glipizide tablets use dry compression technology or inclusion Methods such as increasing the stability of preparation, stripping is unstable, often produces some side effects when taking clinically. Contents of the invention [0003] In order to overcome the deficiencies of the prior art, the present invention provides a glipizide t...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/64A61P3/10B01F7/18
CPCA61K9/2054A61K31/64B01F27/11251B01F27/074B01F27/2122B01F27/191B01F27/90
Inventor 李洋
Owner NANJING HUAKUANG INFORMATION CONSULTING CENT
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