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Amlodipine besylate tablet for treating hypertension and preparation method thereof

A technology of amlodipine besylate tablets and amlodipine besylate, which is applied to chemical instruments and methods, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as dissolution instability, and achieve simple structure , simple preparation process and convenient operation

Inactive Publication Date: 2016-11-09
NANJING HUAKUANG INFORMATION CONSULTING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing amlodipine besylate tablets all adopt the dry compression process or use methods such as inclusion to increase the stability of the preparation, and the dissolution is unstable, and some side effects are often produced when patients take it clinically

Method used

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  • Amlodipine besylate tablet for treating hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 15g of amlodipine besylate, 35g of microcrystalline cellulose, 50g of lactose, 15g of L-tyrosine, 35g of pregelatinized starch, 20g of calcium sulfate dihydrate, 8g of croscarmellose sodium, and 8g of crosslinked Povidone 8g, magnesium stearate 1g.

[0018] Preparation process: put the amlodipine besylate raw material in a pulverizing equipment to pulverize; mix the pulverized amlodipine besylate raw material with the above-mentioned excipients in a particle mixer according to the amount, granulate according to a conventional method, press Tablets, packed into finished products.

[0019] Particle mixers above, see figure 1 , comprising a stirring barrel 1, a stirring shaft 2 arranged in the stirring barrel 1 and a stirring motor 3 arranged on the stirring barrel 1 and connected with the stirring shaft 2, and the stirring shaft 2 is provided with a stirring The paddle 4 is provided with a through hole 5 on the stirring paddle 4, an annular groove 6 is provided on...

Embodiment 5

[0032] The release research of embodiment 5 amlodipine besylate tablets

[0033] Get respectively the tablet that the embodiment of the present invention 1, comparative example 2-4 prepare, according to dissolution assay (" Chinese Pharmacopoeia > 2010 edition two appendix X c second method), take hydrochloric acid solution (0.9→1000mL) as Solvent, the rotating speed is 75 revolutions per minute, operate according to the law, after 15 minutes, take an appropriate amount of solution, filter, and take the subsequent filtrate as the test solution; in addition, accurately weigh amlodipine besylate dried to constant weight at 105 °C An appropriate amount of standard substance was added to hydrochloric acid solution to make a solution containing 10g amlodipine besylate per 1ml, as a reference substance solution. Precisely measure the appropriate amount of the above two solutions, according to spectrophotometry ("Chinese Pharmacopoeia > 2010 edition two appendix VIA), respectively me...

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Abstract

The invention relates to an amlodipine besylate tablet for treating hypertension and a preparation method thereof, and belongs to the technical field of western medicine preparation. The amlodipine besylate tablet comprises 10-20 parts of amlodipine besylate, 20-50 parts of microcrystalline cellulose, 30-70 parts of lactose, 10-20 parts of L-tyrosine, and 20-50 parts of pregelatinized starch. The materials are mixed with a special particle blender. The tablet is stable to release.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to an amlodipine besylate tablet for treating hypertension. Background technique [0002] Amlodipine besylate is the third-generation long-acting dihydropyridine calcium channel antagonist, which mainly inhibits the calcium storage capacity of myocardial and vascular smooth muscle cell membranes and the ability to combine with calcium ions, allowing extracellular calcium ions to enter through slow channels. The reduction of flow muscle cells directly relaxes vascular smooth muscle, expands vascular arterioles, reduces peripheral resistance, and achieves the effect of lowering blood pressure. It has long half-life, high bioavailability, mild, slow and long-lasting action, few side effects, remarkable curative effect, easy to use, does not affect blood lipid and blood sugar metabolism, and has no damage to liver and kidney functions. Existing amlodipine besylate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4422A61P9/12B01F7/18B01F15/00
CPCA61K9/0002A61K9/2059A61K31/4422B01F27/11251B01F27/90B01F35/123
Inventor 李洋
Owner NANJING HUAKUANG INFORMATION CONSULTING CENT
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