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Theophylline sustained-release tablet for treating bronchial asthma and method for preparing theophylline sustained-release tablet

A technology for bronchial asthma and sustained-release tablets, which is applied to chemical instruments and methods, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of unstable release of theophylline tablets and large fluctuations in blood drug concentration , Inconvenient for patients to take and other problems, achieve simple structure, stable release, and solve the effect of uneven stirring

Inactive Publication Date: 2016-11-09
NANJING HUAKUANG INFORMATION CONSULTING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The release of theophylline tablets currently used clinically is unstable. Therefore, the time of taking the medicine must be regularly spaced to ensure that the blood drug concentration maintains a therapeutic level. There are inconveniences for patients to take, forgetting to take or missing doses, and large fluctuations in blood drug concentration. and other shortcomings

Method used

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  • Theophylline sustained-release tablet for treating bronchial asthma and method for preparing theophylline sustained-release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take the weight of the following raw and auxiliary materials in proportion, and in terms of the total weight percentage of the sustained-release tablet, the plain tablet is composed of the following ingredients: 50 parts of theophylline, 20 parts of L-alanine, 20 parts of polyvinylpyrrolidone, stearin Magnesium acid 5 parts, alginic acid 8 parts and lactose 10 parts. The weight formula ratio of the coating is as follows: 2 parts of sodium carboxymethylcellulose, 2 parts of propylene glycol, and 1 part of talcum powder.

[0021] Preparation Process:

[0022] (1) Dissolving polyvinylpyrrolidone in an ethanol solution to prepare an alcoholic solution; (2) putting the sieved theophylline, remaining polyvinylpyrrolidone, L-alanine, alginic acid, and lactose in a particle mixer (3) Add the lubricating glidant magnesium stearate after drying the above-mentioned soft material to obtain a mixed powder, and add all the mixed powder To a motion mixer, use a rotary lozenge machin...

Embodiment 5

[0036] The Release Research of Embodiment 5 Theophylline Sustained-release Tablets

[0037]Dissolution test method: get respectively embodiment 1 of the present invention, comparative example 2,3,4 to compare, according to the release determination method (two appendix XD first methods of Chinese Pharmacopoeia version in 2010), appendix of Chinese Pharmacopoeia version in 2010, blue The method is 75 revolutions / min, and 1000ml of fresh water with air removed is used as the release solvent for this product. Select UV spectrophotometry at 233nm to determine the release rate of theophylline sustained-release tablets by absorption coefficient method.

[0038] The sustained-release tablet release test result prepared by each embodiment of table 1

[0039] Sample source

[0040] According to the test results of Table 1, it can be seen that the theophylline sustained-release tablet prepared by Example 1 of the present invention releases smoothly; in comparative example 2-3...

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Abstract

The invention relates to a theophylline sustained-release tablet for treating bronchial asthma, and belongs to the technical field of preparations of western medicines. The theophylline sustained-release tablet comprises streptomycin and coatings, and is characterized in that the streptomycin comprises, according to the total weight percent of the theophylline sustained-release tablet, 30-70 parts of theophylline, 10-30 parts of L-alanine, 10-30 parts of polyvinylpyrrolidone, 1-10 parts of lubricating glidants, 5-15 parts of alginic acid and the like, and components in the streptomycin are mixed with one another by the aid of a specific granule stirring machine. The theophylline sustained-release tablet has the advantage that the theophylline sustained-release tablet can be stably released in a sustained manner.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a theophylline sustained-release tablet for treating bronchial asthma. Background technique [0002] Theophylline sustained-release tablets are indicated for bronchial asthma, wheezing bronchitis, and obstructive emphysema to relieve wheezing symptoms; they can also be used for asthma caused by cardiogenic pulmonary edema. The release of theophylline tablets currently used clinically is unstable. Therefore, the time of taking the medicine must be regularly spaced to ensure that the blood drug concentration maintains a therapeutic level. There are inconveniences for patients to take, forgetting to take or missing doses, and large fluctuations in blood drug concentration. and other shortcomings. Contents of the invention [0003] In order to overcome the deficiencies of the prior art, the present invention provides a theophylline sustained-release tablet th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/522A61K47/36A61K47/38A61P11/06A61P11/00B01F7/18B01F15/00
CPCA61K9/0002A61K9/205A61K9/2866A61K31/522B01F27/11251B01F27/90B01F35/123
Inventor 李洋
Owner NANJING HUAKUANG INFORMATION CONSULTING CENT
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