Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Metformin hydrochloride sustained release tablets capable of reducing blood glucose and preparation method of metformin hydrochloride sustained release tablets

A technology of metformin hydrochloride and sustained-release tablets, which is applied in chemical instruments and methods, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of large fluctuations in blood drug concentration, easy forgetting, and missed doses and other problems, to achieve the effect of simple structure, solving uneven mixing and stable release

Inactive Publication Date: 2016-11-09
NANJING HUAKUANG INFORMATION CONSULTING CENT
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the time of taking the medicine must be regularly spaced to ensure that the blood drug concentration maintains the therapeutic level, and there are disadvantages such as inconvenience for patients to take, easy to forget to take, missed dose, and large fluctuations in blood drug concentration.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Metformin hydrochloride sustained release tablets capable of reducing blood glucose and preparation method of metformin hydrochloride sustained release tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Raw and auxiliary materials were weighed in proportion: 50 parts of metformin hydrochloride, 20 parts of D-mannitol, 20 parts of cross-linked hydroxymethyl cellulose, 5 parts of magnesium stearate, 15 parts of guar gum and 10 parts of lactose, methyl 2 parts of cellulose, 2 parts of sodium carboxymethyl cellulose, 3 parts of propylene glycol, 3 parts of polyvinylpyrrolidone, 1 part of No. IV acrylic resin, and 1 part of talcum powder.

[0021] Preparation Process:

[0022] Put the sieved metformin hydrochloride, D-mannitol, cross-linked hydroxymethyl cellulose, guar gum, and lactose in a particle mixer and fully mix to obtain a soft material; (3) dry the above soft material Finally, magnesium stearate is added to obtain mixed powder, which is all added to a multi-directional motion mixer, and is compressed into tablets using a rotary tablet machine to obtain plain tablets; (4) preparation of coating solution: after talcum powder is sieved Mix evenly, add methyl cellulo...

Embodiment 5

[0036] The release research of embodiment 5 metformin hydrochloride sustained-release tablets

[0037]Release test method: get respectively the tablet prepared by embodiment 1 and comparative example 2-4, according to release test method (Chinese Pharmacopoeia version in 2010 two appendix XD first method), Chinese Pharmacopoeia version appendix in 2010, blue method 75 Turn / min, use 1000ml of fresh water to remove air as the release solvent for this product. The release rate of metformin hydrochloride sustained-release tablets was determined by UV spectrophotometry at 233nm using the absorption coefficient method.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to metformin hydrochloride sustained release tablets capable of reducing blood glucose and belongs to the technical field of western medicine preparations. Each tablet comprises a naked tablet and a coating and is characterized in that on the basis of the total weight of each sustained release tablet, the naked tablet is prepared from components as follows: 30-70 parts of metformin hydrochloride, 10-30 parts of D-mannitol, 10-30 parts of crosslinked hydroxymethyl cellulose, 1-10 parts of a lubricating flow aid and the like. A special granule stirrer is used for mixing. The tablets are stable in sustained release.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a metformin hydrochloride slow-release tablet for lowering blood sugar. Background technique [0002] Metformin hydrochloride is a biguanide hypoglycemic drug that can be taken orally and is widely used. It is the only oral biguanide antihyperglycemic drug still used in developed countries in the world. And postprandial plasma glucose concentration, the mechanism of action is different from other antidiabetic drugs. Metformin hydrochloride reduces glycogen production, reduces the absorption of sugar in the small intestine, and improves insulin resistance by increasing the uptake and utilization of peripheral sugar. In normal people and patients with type 2 diabetes, neither hypoglycemia nor hyperinsulinemia occurs. Metformin hydrochloride currently used clinically is common tablets and capsules, etc., and the usual dosage is 1.5g per day, taken in three di...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/155A61K47/38A61P3/10B01F7/18B01F15/00
CPCA61K9/0002A61K9/2054A61K9/2866A61K31/155B01F27/11251B01F27/90B01F35/123
Inventor 李洋
Owner NANJING HUAKUANG INFORMATION CONSULTING CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com