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Lansoprazole enteric-coated tablet for treating gastric ulcer and preparation method thereof

A technology of lansoprazole enteric and lansoprazole, which is applied in the field of lansoprazole enteric-coated tablets, can solve the problems that the blood drug concentration cannot maintain the therapeutic level, the blood drug concentration fluctuates greatly, and it is inconvenient for patients to take it. Simple, stable release, solve the effect of uneven mixing

Inactive Publication Date: 2016-08-24
NANJING HUAKUANG INFORMATION CONSULTING CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Lansoprazole enteric-coated tablets currently used clinically are highly irritating to the stomach, and the blood drug concentration cannot maintain the therapeutic level. There are disadvantages such as inconvenience for patients to take, easy to forget to take or miss doses, and large fluctuations in blood drug concentration.

Method used

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  • Lansoprazole enteric-coated tablet for treating gastric ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 50 parts of lansoprazole, 15 parts of anhydrous calcium hydrogen phosphate, 20 parts of polyvinylpyrrolidone, 5 parts of magnesium stearate, 10 parts of cross-linked hydroxymethyl cellulose; 8 parts of acrylic resin No. Ⅱ, acrylic acid Resin No. 12 parts.

[0019] Preparation Process:

[0020] (1) dissolving polyvinylpyrrolidone in ethanol solution to prepare alcoholic solution; (2) lansoprazole after sieving, remaining polyvinylpyrrolidone, L-alanine, alginic acid and lactose in Fully mix in a particle mixer, add the above-mentioned alcohol solution of polyvinylpyrrolidone, and mix thoroughly to obtain a soft material; (3) After drying the above-mentioned soft material, add magnesium stearate to obtain a mixed powder, and all the mixed powder is added to the multi-directional movement Mixer, use rotary lozenge machine tablet, make plain tablet; (4) preparation of coating solution: talcum powder is sieved and mixed, add in the ethanol solution containing sodium c...

Embodiment 5

[0034] The release research of embodiment 5 Lansoprazole enteric-coated tablets

[0035] Release test method: get the tablet prepared by Example 1 of the present invention and comparative example 2-4 respectively, according to release test method (Chinese Pharmacopoeia version two appendix XD first method in 2010), Chinese Pharmacopoeia version appendix in 2010, blue The method is 75 rev / min, and 1000ml of artificial intestinal fluid is used as the release solvent for this product. The release rate of Lansoprazole Enteric-coated Tablets was determined by UV spectrophotometry at 233nm using the absorption coefficient method.

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Abstract

The invention relates to a lansoprazole enteric-coated tablet for treating gastric ulcer and belongs to the technical field of Western medicine preparations. The lansoprazole enteric-coated tablet is composed of a tablet body and a coat, and the tablet body of the enteric-coated tablet is composed of, by total weight, 30-70 parts of lansoprazole, 10-20 parts of anhydrous calcium hydrophosphate and 10-30 parts of polyvinylpyrrolidone. A specific granule stirrer is adopted for mixing. The tablet is stable in slow release.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a lansoprazole enteric-coated tablet for treating gastric ulcer. Background technique [0002] Lansoprazole tablets, indications for gastric ulcer, duodenal ulcer, reflux esophagitis, Zoller-Ellison syndrome (gastrinoma). Lansoprazole enteric-coated tablets currently used clinically are highly irritating to the stomach, and the blood drug concentration cannot maintain the therapeutic level. There are disadvantages such as inconvenience for patients to take, easy to forget to take or miss doses, and large fluctuations in blood drug concentration. Contents of the invention [0003] In order to overcome the deficiencies in the prior art, the present invention provides a lansoprazole enteric-coated tablet through a large number of tests on auxiliary material screening, process optimization and equipment improvement. The tablet is sustained-release, has small ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/32A61K31/4439A61J3/00A61P1/04A61P35/00
CPCA61K31/4439A61J3/005A61K9/2846
Inventor 李洋
Owner NANJING HUAKUANG INFORMATION CONSULTING CENT
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