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Sustained release preparation of glipizide/metformin hydrochloride and its preparation method

A technology of metformin hydrochloride and sustained-release preparations, which is applied in pharmaceutical formulations, metabolic diseases, drug combinations, etc., to achieve the effects of improving curative effect and drug safety, reducing irritation, and promoting secretion

Inactive Publication Date: 2005-04-06
海南国栋药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no preparation that can not only protect the stomach but also have a synergistic effect of the active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] According to prescription 1 of the sustained-release tablet, take the glipizide of the prescription amount (crushed through a 100 mesh sieve) and mix evenly with an appropriate amount of carmellose sodium, then add metformin hydrochloride powder and appropriate amount of powder crushed through a 100 mesh sieve according to the prescription amount. Mix the hypromellose evenly, then add a proper amount of hypromellose aqueous solution not exceeding 5% to make a soft material, pass through a 20-mesh sieve to granulate, dry at 60°C for 4 hours, pass through a 16-mesh sieve for granulation, add An appropriate amount of magnesium stearate is mixed evenly, the content is tested, the weight of the tablet is calculated, and the corresponding die is selected to press the tablet. After passing the inspection, it is then packaged in aluminum and plastic, boxed, boxed, and packed, and put into storage after passing the inspection.

Embodiment 2

[0030] According to the sustained-release tablet prescription 2, take the glipizide of the prescribed amount (crushed through a 100 mesh sieve) and mix evenly with an appropriate amount of carmellose sodium, then add metformin hydrochloride powder and appropriate amount of powder crushed through a 100 mesh sieve according to the prescribed amount. Mix the hypromellose evenly, then add a proper amount of hypromellose aqueous solution not exceeding 5% to make a soft material, pass through a 20-mesh sieve to granulate, dry at 60°C for 4 hours, pass through a 16-mesh sieve for granulation, add An appropriate amount of magnesium stearate is mixed evenly, the content is tested, the weight of the tablet is calculated, and the corresponding die is selected to press the tablet. After passing the inspection, it is then packaged in aluminum and plastic, boxed, boxed, and packed, and put into storage after passing the inspection.

Embodiment 3

[0032] According to the sustained-release tablet prescription 3, the glipizide (crushed through a 100 mesh sieve) of the prescribed amount is weighed and mixed with an appropriate amount of carmellose sodium, and then the metformin hydrochloride powder and an appropriate amount of metformin hydrochloride crushed through a 100 mesh sieve are added according to the prescribed amount. Mix the hypromellose evenly, then add a proper amount of hypromellose aqueous solution not exceeding 5% to make a soft material, pass through a 20-mesh sieve to granulate, dry at 60°C for 4 hours, pass through a 16-mesh sieve for granulation, add An appropriate amount of magnesium stearate is mixed evenly, the content is tested, the weight of the tablet is calculated, and the corresponding die is selected to press the tablet. After passing the inspection, it is then packaged in aluminum and plastic, boxed, boxed, and packed, and put into storage after passing the inspection.

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PUM

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Abstract

The invention relates to a compound sustained-release preparation composed of glipizide and metformin hydrochloride, and its preparing method. The weight ratio of glipizide to metformin hydrochloride is 1 : 100-200, the best ratio is 1:100 and it adds a proper amount of medicinal auxiliary to the preparation. The compound sustained-release tablet can not only make advantages complementation on glipizide and metformin hydrochloride, promote and increase secretion of beta-cell insulin, and raise the utilization of glucose in tissues, such as muscle, etc, but also reduce the stimulus of metformin hydrochloride to stomach intestine, and largely strengthen curative effect and drug application safety.

Description

【Technical field】 [0001] The invention relates to a hypoglycemic preparation, namely glipizide hydrochloride sustained-release preparation of metformin hydrochloride and a preparation method thereof. 【Background technique】 [0002] Glipizide Metformin Hydrochloride Tablets is a compound preparation containing glipizide and metformin hydrochloride, two oral antihyperglycemic drugs for the treatment of type 2 diabetes, developed by Bristol-Myers Squibb Company. It was launched in October 2002 It was approved for marketing in the U.S. for the first time, and its product name is Metaglip®. The dosage form on the market is oral tablet, and its specifications include (glipizide / metformin hydrochloride) 2.5mg / 250mg, 2.5mg / 500mg, and 5mg / 500mg. At present, glipizide sustained-release tablets, capsules and metformin hydrochloride sustained-release tablets for the treatment of diabetes have been listed in China, and the compound preparation of glipizide metformin hydrochloride has not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K31/4965A61P3/10
Inventor 梁国栋张纲杨东云
Owner 海南国栋药物研究所有限公司
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