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Oral disintegration tablet for dropping blood sugar and preparation method

An orally disintegrating tablet and hypoglycemic technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, pill delivery, etc., can solve problems such as patient inconvenience, and achieve the effect of improving specificity and accuracy of the method

Inactive Publication Date: 2006-02-01
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to overcome the shortcoming that the oral preparation of the hypoglycemic drug glipizide needs water and may cause inconvenience to the patient when taking the medicine, and the orally disintegrating drug that can be rapidly disintegrated in the oral cavity without water is made by using special auxiliary materials. Tablets

Method used

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  • Oral disintegration tablet for dropping blood sugar and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Glipizide 5.00g

[0057] Mannitol 11.18g

[0058] Microcrystalline Cellulose 5.48g

[0059] Crospovidone 3.29g

[0060] Aspartame 0.02g

[0061] Magnesium stearate 0.11g

[0062] Povidone K 30 0.33g

[0063] Weigh glipizide, mannitol, microcrystalline cellulose, crospovidone, and aspartame respectively according to the proportioning ratio and add them into the mixing tank by adding in equal amounts, mix well, and use 2% povidone alcohol Solution (prepared povidone alcohol solution with 60% ethanol solution) to make soft materials, granulate with 40 mesh sieve, blow dry at 50-60°C, granulate with 40 mesh sieve, add magnesium stearate, mix evenly, punch and press piece.

Embodiment 2

[0065] Glipizide 5.00g

[0066] Mannitol 22.36g

[0067] Microcrystalline Cellulose 10.95g

[0068] Crospovidone 6.57g

[0069] Aspartame 0.04g

[0070] Magnesium stearate 0.22g

[0071] Povidone K 30 0.66g

[0072] Weigh glipizide, mannitol, microcrystalline cellulose, crospovidone, and aspartame respectively according to the proportioning ratio and add them into the mixing tank by adding in equal amounts, mix well, and use 2% povidone alcohol Solution (prepared povidone alcohol solution with 60% ethanol solution) to make soft materials, granulate with 40 mesh sieve, blow dry at 50-60°C, granulate with 40 mesh sieve, add magnesium stearate, mix evenly, punch and press piece.

Embodiment 3

[0074] Glipizide 5.00g

[0075] Mannitol 55.15g

[0076] Microcrystalline Cellulose 27.00g

[0077] Crospovidone 16.20g

[0078] Aspartame 0.11g

[0079] Magnesium stearate 0.54g

[0080] Povidone K 30 1.65g

[0081] Weigh glipizide, mannitol, microcrystalline cellulose, crospovidone, and aspartame respectively according to the proportioning ratio and add them into the mixing tank by adding in equal amounts, mix well, and use 2% povidone alcohol Solution (prepared povidone alcohol solution with 60% ethanol solution) to make soft materials, granulate with 40 mesh sieve, blow dry at 50-60°C, granulate with 40 mesh sieve, add magnesium stearate, mix evenly, punch and press piece.

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PUM

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Abstract

An orally disintegrating hypoglycemic tablet is prepared from glipizide, filler, disintegrant, flavouring, lubricant and adhesive. Its advantage is short disintegrating time (less than 60 S). Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a hypoglycemic drug capable of rapid disintegration and absorption in the oral cavity, in particular to an orally disintegrating tablet preparation made of glipizide as an active component. The invention also relates to the preparation method of the preparation. Background technique [0002] Diabetes mellitus is an endocrine and metabolic disease characterized by elevated blood sugar. In recent years, the incidence of the disease in middle-aged and elderly groups has been increasing year by year, and the age of onset is also tending to be younger. The number of people with diabetes in my country is growing at a rate of 10% per year. Among diabetic patients, type I diabetes patients are relatively few (accounting for about 5%), which belong to autoimmune diseases, while type II diabetes patients account for the majority (accounting for about 90%). It is a common frequently-occurring disease after vascular disease, and its dru...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61K9/20A61P3/10
Inventor 曾文丽陈梅荣尧享华肖小华胡健朱红
Owner 江西省药物研究所
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