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Rhodiola effective fractions, preparation method, drug composition and uses thereof

An effective part, Rhodiola rosea technology, applied in the field of medicine, can solve problems such as edema and weight

Active Publication Date: 2012-07-04
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main side effects of this class of drugs are edema and weight gain

Method used

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  • Rhodiola effective fractions, preparation method, drug composition and uses thereof
  • Rhodiola effective fractions, preparation method, drug composition and uses thereof
  • Rhodiola effective fractions, preparation method, drug composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Use the dried rhizome of Rhodiola rosea as the original drug, crush it and extract it 3 times with 80% ethanol under reflux, each time the dosage is 8 times the weight of the original drug, and the extraction time is 2 hours each time. Concentrate under reduced pressure to recover ethanol until there is no alcohol smell, and obtain the extract, adjust the density of the extract to 1.16, add 5 times the amount of water to carry out water precipitation, stand at 5°C for 72 hours, filter the precipitate, concentrate the filtrate under reduced pressure, and perform HP -20 macroporous adsorption resin separation, using three gradients of pure water, 50% ethanol, and 95% ethanol for elution, concentrating the eluent of 50% ethanol under reduced pressure, and obtaining the effective part of Rhodiola rosea after freeze-drying .

Embodiment 2

[0088] Adopt the dry rhizome of Rhodiola angustifolia as the original drug, grind and extract 2 times with 95% ethanol backflow, each dosage is 7 times of the weight of the original drug, and the extraction time is 3 hours each time, the extracts are combined and filtered, and the filtrate is reduced Concentrate under pressure to recover ethanol until there is no alcohol smell, and obtain the extract, adjust the density of the extract to 1.18, add 8 times the amount of water to carry out water precipitation, stand at 5°C for 96 hours, filter the precipitate, and perform HP- Separation with 40 macroporous adsorption resins, using four gradients of pure water, 5% ethanol, 50% ethanol, and 95% ethanol for elution, concentrating the eluent of 50% ethanol under reduced pressure, and obtaining Rhodiola angustifolia after freeze-drying effective part.

Embodiment 3

[0090] Adopt dry Rhodiola rosea rhizome as the original drug, crush it and extract it twice with 70% methanol under reflux, each dosage is 8 times the weight of the original drug, and the extraction time is 2 hours each time, the extracts are combined and filtered, and the filtrate Concentrate under reduced pressure to recover methanol to obtain an extract, adjust the density of the extract to 1.17, add 6 times the amount of water for water precipitation, stand at 5°C for 48 hours, filter the precipitate, and concentrate the filtrate under reduced pressure for D101 macroporous adsorption resin The separation is carried out by four gradients of pure water, 5% ethanol, 50% ethanol and 95% ethanol for elution, the eluate of 50% ethanol is concentrated under reduced pressure, and the effective fraction of Rhodiola rosea is obtained after freeze-drying.

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Abstract

The present invention relates to effective fractions, a preparation method of the effective fractions, drug compositions of the effective fractions, and uses of the effective fractions in preparations of anti-metabolism syndrome drugs, wherein the effective fractions are prepared by carrying out extracting separation on a rhodiola plant.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an effective part extracted and separated from plants of the genus Rhodiola, its preparation method, its pharmaceutical composition and their application in preparing anti-metabolic syndrome drugs. Background technique [0002] Rhodiola is a plant of the genus Rhodiola in the family Crassulaceae. There are about 90 species in the world, mostly distributed in the Himalayas, from west to north Asia, through Korea, Japan to North America, and China is the distribution center of Rhodiola. There are about 70 species of rhodiola plants in my country, mainly distributed in the southwest, northwest, north, central and northeast regions. The southwest and northwest regions have many types and relatively large reserves. Among them, more than 30 species are produced in Tibet, and the distribution of resources is relatively rich, ranking first in the world in terms of species and reserve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P3/04A61P3/06A61P3/10A61P5/50A61K125/00
Inventor 张培成叶菲杨桠楠田金英冯子明张晓琳姜建双陈玲刘照振贺伊博陈钟韩静刘峻玚
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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