38 results about "Primary sites" patented technology

An embodiment provisions a Validation Area within a consistency group of a primary site and a Validation Area within a consistency group of a secondary site. The embodiment provisions a Validation Writer in the primary site and provisions a Validation Reader in the secondary site; the Validation Writer writes a validation metric into the Validation Area in the primary site at an interval determined by a recovery point objective. The embodiment also reads the validation metric by the Validation Reader in the secondary site, computes a validation result based on the validation metric, the recovery point objective and a recovery point time delta where the validation result comprises an outcome of a replication of the primary site to the secondary site where the Validation Area of the primary site, the Validation Area of the secondary site, the Validation Writer and the Validation Reader are storage and application agnostic.

A service migration technique moves (migrates) a snapshot storage service of an archival storage system from a primary site to a secondary site in accordance with a planned failover event. The snapshot storage service is configured to provide storage and retrieval of large amounts of snapshots (e.g., recovery points) of application workloads stored as objects on one or more buckets of an object store. As part of finalization of the recovery points (RPs) at the primary site, the snapshot storage service stores snapshot data and metadata of the RPs (e.g., as service state) in the object store. The snapshot storage service may then be migrated to the secondary site, wherein migration involves terminating the service at the primary site and instantiating the service at the secondary site. The instantiated storage service instance may then rebuild its service state from the object store, and resume storage and retrieval operations directed to RPs serviced by the instance.

Systems, computer program products, and methods are described herein for auto-establishing data transfers between data centers for batch processing. The present disclosure is configured to identify a process associated with a primary site; determine a backup site associated with the primary site; apply the process to the backup site; generate, by an imitation artifact component, a record counter of the process as the process runs in the primary site, wherein the record counter comprises a cursor position indicating a current operation of the process; and mimic, based on the record counter, the process in the backup site as the process runs in the primary site.

The present application relates to the technical field of nucleic acid detection, in particular to a RNA pathogen chemiluminescence detection method based on nucleic acid structure and sequence characteristics. The present application provides a pathogen RNA rapid detection technology based on the reporter molecule cyclization combined with rolling circle amplification according to the secondary structure and sequence characteristics of RNA, which is suitable for high-sensitivity and high-specificity detection of RNA pathogens such as respiratory viruses. The present application innovatively combines the target structure characteristics with sequence specificity, breaks through the traditional sequence-dependent isothermal amplification technology, realizes the highly specific reporter molecule cyclization, significantly improves the detection reliability, and does not require complex instruments. After the swab sample is collected, the pathogen RNA is rapidly released by using a nucleic acid releasing agent, without complex purification steps, and the reading can be realized through a common chemiluminescence instrument, which is suitable for primary site detection.

The application provides a cancer primary focus tracing method, device, system and storage medium, and relates to the technical field of cancer tracing. The cancer primary focus tracing method comprises the following steps: acquiring sample tissue data, giving each cancer sample a primary focus label through a methylation chip; determining candidate CpG sites; and constructing a cancer tracing classifier. The application realizes the technology of tracing multiple cancers by using DNA methylation biological characteristics and machine learning methods, and has the following characteristics: due to the high stability of DNA molecules, cancer information is relatively completely retained, so that sample storage and transportation are more convenient; the cancers targeted by the application have a wide coverage range and include general common tumors; cancer-specific CpG sites have a wide coverage; through analysis of the cancer-specific sites, the interference of normal tissues is excluded, so that the accuracy and application range of the classifier are improved; and the high-precision classifier makes the cancer diagnosis process simpler, more accurate and more efficient.

The invention belongs to the technical field of biological medicine, and particularly relates to application of coniferyl aldehyde in preparation of anti-cancer drugs. The invention discloses application of coniferyl aldehyde in preparation of anti-cancer drugs, coniferyl aldehyde can significantly inhibit invasion and migration ability of hepatocellular carcinoma cells, cancer cells cannot break through primary parts through key links such as interference of movement and adhesion of the cancer cells and degradation of extracellular matrixes, invasion of tumors to surrounding tissues is reduced, and the anti-cancer effect is improved. The occurrence rate of remote metastasis is reduced, the non-metastasis lifetime of the patient is prolonged, and more treatment time and survival opportunities are won for the patient; a large number of cell experiments and animal experiments prove that the medicine has no obvious liver and kidney toxicity under the treatment dosage, the tolerance of a patient to treatment is improved, the smooth proceeding of the treatment process is guaranteed, and the living quality of the patient is effectively improved.

A computer system includes a primary site having a primary volume, and having an instance that performs data processing related to input / output data, and a secondary site having a secondary volume, and having an instance. Remote copy is set up between the primary and secondary volumes, and the instance of the primary site transfers data input to or outputted from the primary volume to the secondary site, while the instance of the secondary site stores the transferred data in the secondary volume. The computer system further includes a specifications changing section that changes specifications of the instance of the secondary site when a failover switching process of switching a performer of the data processing from the primary to secondary site is performed, or when a failback switching process of switching the performer of the data processing from the secondary to primary site after the failover switching process is performed.

The application discloses a test strip RPA primer for detecting potato brown stem nematode, wherein the primer is composed of a nucleotide sequence shown in SEQ ID No:1 and SEQ ID No:2; a combination of the primer and a probe is also disclosed, wherein the probe is composed of a sequence shown in SEQ ID No:3. In addition, a detection kit comprising the primer and the probe combination is disclosed. The test strip RPA primer and the probe combination of the application have the advantages of high specificity and sensitivity for detecting potato brown stem nematode, low requirement for equipment and personnel quality, simple operation, fast detection speed and low cost, and are suitable for port quarantine and primary site detection.

The application relates to a hapten for detecting ethoxyquin, a complete antigen and a use method thereof. The application discloses a hapten for detecting ethoxyquin, and then a complete antigen obtained by coupling ethoxyquin hapten with hemocyanin is used as an immunogen, and a complete antigen obtained by coupling ethoxyquin hapten with chicken egg white albumin is used as a coating agent. An indirect detection enzyme-linked immunoassay method for ethoxyquin is established. The half-inhibition concentration of the method for ethoxyquin is 0.96 ug / mL, the detection limit is 0.6 ug / mL, the linear detection range is 0.72 ug / mL-1.28 ug / mL, and the curve correlation coefficient is 0.996. The method is high in specificity and sensitivity, simple and fast, and has a wide application prospect in the detection of ethoxyquin residues in food. The method is very suitable for realizing rapid qualitative or quantitative detection of ethoxyquin in food by primary site personnel.

A method and system for data synchronization between a standby site and a primary site in a distributed database system is provided. A first primary site included in a primary site group of the distributed database system generates a commit action redo log message for a commit action performed by the first primary site on a first database transaction, the commit action redo log message including a transaction ID of the first database transaction and a transaction order indicator representing an order of database transactions in a group of database transactions executed on one or more primary sites in the primary site group. The first primary site sends the commit action redo log message to a corresponding first standby site backing up the first primary site.

The application discloses an automatic prognosis system for nasopharyngeal carcinoma primary focus and lymph node nuclear magnetic resonance image, which comprises a data preparation module, a segmentation module, a feature sharing module, a data processing module and a prognosis module; the data preparation module puts all nuclear magnetic resonance images of a patient into a folder in a patient unit; the segmentation module is used for processing data obtained by the data preparation module; the feature sharing module uses an expansion convolution group to reduce dimensions of each layer multi-scale deep features obtained by the segmentation module but maintains the scale unchanged; the data processing module uses a prediction map generated by the segmentation module and the nuclear magnetic resonance image obtained by the data preparation module to perform a mask strategy; the prognosis module is used for processing a lesion map obtained by the data processing module and the multi-scale deep features processed by the feature sharing module to obtain a prediction value, finally uses the prediction value to obtain a survival probability of the patient, and realizes risk stratification of the patient and gives a suggestion on whether to accept chemotherapy; the application can automatically realize prognosis prediction of the nasopharyngeal carcinoma patient, realizes automation in the whole process and avoids manual participation.

This application relates to a data reading method, apparatus, electronic device, and storage medium. The method includes: receiving a data reading request, the data reading request including index information of a target object; obtaining the synchronization status of the target object; in response to an incomplete initial synchronization, determining the primary site as the target site and a first local storage bucket as the target data address; reading target object data from the first local storage bucket according to the index information; in response to a completed initial synchronization, obtaining the deletion status of the target object and the deletion policy of the object storage system; determining the target site and the corresponding target data address based on the deletion policy and deletion status; and reading the target object data from the target data address of the target site according to the index information. This method ensures that the data obtained by the user on different sites remains consistent and is always the latest version of the object.

To propose a configuration that achieves both performance and cost when a secondary site of remote copy is constructed on a cloud.SOLUTION: A computer system includes: a storage system in which a primary site is constructed that provides one or a plurality of positive volumes to a host; a storage cluster that is connected to the storage system via a network and has a plurality of nodes; and a management computer. When a secondary site having a primary volume and a secondary volume to which a remote copy of the primary site is set is constructed in the storage cluster, the management computer manages a plurality of volumes including the secondary volume as a group and controls the plurality of volumes including the secondary volume to be arranged in a plurality of nodes of the storage cluster based on the group.SELECTED DRAWING: Figure 1

Methods for predicting a cutaneous primary site of disease are described. The methods may comprise, for example, receiving, using one or more processors, sequence read data associated with a sample from the individual, selecting, using the one or more processors, a plurality of reads from the sequence read data, determining, using the one or more processors, an ultra-violet (UV) signature metric based on the selected plurality of reads, inputting, using the one or more processors, the UV signature metric into a statistical model, and predicting, using the one or more processors, the primary site of the disease in the individual based on an output of the statistical model.

Systems and methods for allowing and maintaining Input / Output (I / O) operations in a distributed storage system with multiple storage sites when communications links between the sites fail are provided. Mirrored storage sites use an update policy, including an update record and a bitmap configured to track changes in memory blocks storing an I / O request. When a link between two or more sites fails, one or more of the sites may be designated as a primary site, on which normal I / O operations may continue. One or more sites may also be designated as non-primary sites and are “detached” with respect to the primary site or sites. I / O operations on the non-primary sites may be suspended until the link is restored. When the link is restored, the update records and bitmaps are used to rebuild the detached sites.

A smart prefetching of operations technique prefetches metadata and / or data of objects stored in a multi-cloud snapshot technology (MST) service associated with an object store. One or more data objects (e.g., an application) at a primary site may be designated for backup or failover to a secondary site, e.g., in the event of failure of the primary site. Smart prefetching logic of the MST is configured to prefetch the object metadata and / or object data from the object store to serve subsequent requests without accessing the object store. To that end, when storing data to the object store as one or more objects, MST maintains specific metadata along with the data of the objects. The technique utilizes the specific metadata to prefetch the object metadata and / or object data before receiving actual read requests for that data to improve the read latency and throughput when restoring the application as soon as possible.

Method, computer program product, and computer system are provided. A controller component verifies the state of all file sets. The controller component initiates a sub-controller component, based on successfully verifying the state of the file sets. The sub-controller component suspends write operations to all databases at the primary site computer. Based on the suspending completing without error, the sub-controller executes point-in-time copy processes for each of the databases and for application non-database files at the primary site computer. Applications using the databases and non-database files are not suspended. Based on all of the point-in-time copy processes completing without error, the sub-controller component resumes write operations to all databases at the primary site computer. The point-in-time copies are automatically sent to the secondary site computer so that the applications can operate at the secondary site computer if the primary site computer becomes unavailable.

An embodiment provisions a Validation Area within a consistency group of a primary site and a Validation Area within a consistency group of a secondary site. The embodiment provisions a Validation Writer in the primary site and provisions a Validation Reader in the secondary site; the Validation Writer writes a validation metric into the Validation Area in the primary site at an interval determined by a recovery point objective. The embodiment also reads the validation metric by the Validation Reader in the secondary site, computes a validation result based on the validation metric, the recovery point objective and a recovery point time delta where the validation result comprises an outcome of a replication of the primary site to the secondary site where the Validation Area of the primary site, the Validation Area of the secondary site, the Validation Writer and the Validation Reader are storage and application agnostic.

A computer-implemented method for generic tenant data replication for disaster recovery, includes regularly checking, by a primary replication agent on a primary site, for changes to a primary change log on the primary site. Based on an insert of a new change record in a secondary change log on a secondary site, triggering a stored procedure from secondary stored procedures on the secondary site, that extracts a change operation and data from the secondary change log and performs the changed operation on a secondary tenant table on the secondary site. By a secondary replication agent on the secondary site and from the primary replication agent, receiving a call not containing a sequence id for a change record marked as completed in the secondary change log, and deleting the change record. Using a replication agents control plane, providing central monitoring for the primary replication agent and the secondary replication agent.

Techniques for migration or disaster recovery of vTPM enabled virtual machines include non-transitory computer-readable media storing program instructions that, when executed by one or more processors associated with a computing device, cause the one or more processors to perform a method including transmitting, by a primary site, an encryption secret for an encrypted storage device to a secondary site, the encrypted storage device storing data encrypted based on the encryption secret; and transmitting, by the primary site using an unsecure channel, the data as encrypted based on the encryption secret to the secondary site.

The invention discloses a UvsY auxiliary protein mutant with improved thermal stability, the thermal stability of the UvsY auxiliary protein mutant is remarkably improved, and the core technical problem that an existing UvsY auxiliary protein is poor in thermal stability is solved. In addition, the UvsY auxiliary protein mutant can still maintain efficient in-vitro nucleic acid amplification activity after being stored for a long time, the peak appearance time is short, the amplification efficiency is stable, strict cold chain transportation and storage are not needed, and the application cost is reduced. The method can be widely applied to various scenes such as RPA and RTMA isothermal amplification technologies, adaptive gene detection and basic-level field diagnosis, and has extremely high practical application value and industrialization prospect.

Violation of a recovery requirement is prevented at the time of a failover to a secondary site in case of failure while suppressing cost on hardware of the secondary site in normal times. In a computer system including: a primary site storage system; a secondary site storage system; and a management device, the management device can change a resource of the secondary site storage system, and in the case where a failure occurs in the primary site, the management device performs a failover of making a corresponding secondary volume take over operation of the primary volume, controls so as to enhance a resource of the secondary site storage system, and controls the failover so that a secondary volume which starts operating by the failover before the enhancement of the resource and a secondary volume which starts operating by the failover after the enhancement of the resource exist.

The present application relates to a resource adjustment method, apparatus, computer equipment and storage medium, and relates to the field of computer technology, and can be used in the field of financial technology or other related fields. The method includes: when the primary site fails, obtaining resource adjustment data for the backup site; generating resource adjustment microcode based on the resource adjustment data and the logic code template; and sending resource adjustment instructions to each host to be adjusted in the backup site based on the resource adjustment microcode to instruct each host to be adjusted to perform local resource adjustments based on the resource adjustment instructions. The use of this method can improve resource adjustment efficiency, significantly reduce time consumption, and enable the backup site to quickly take over the core business of the primary site.

The invention belongs to the technical field of molecular detection of biological medicines, and particularly relates to a nucleic acid extraction-free SFTSV detection kit, primer probes and a method. The primer probe composition comprises an upstream primer SEQ ID NO: 1 for specifically recognizing the SFTSV, a downstream primer SEQ ID NO: 2 of which the 5'end is labeled with biotin, and a probe SEQ ID NO: 3 of which the 5 'end is labeled with a reporter group and contains THF modification. The kit comprises the composition, a nucleic acid releasing agent and a lateral flow chromatography test strip. The method comprises the following steps: treating a serum / plasma sample by using a nucleic acid releasing agent, carrying out RPA isothermal amplification by directly taking a lysate as a template, and detecting a result through a test strip. The RPA-LFD rapid detection of the SFTSV is realized, the sensitivity (200copies / mL) and the specificity are high, the operation is simple, convenient and rapid (about 40 minutes), a complex instrument and a nucleic acid extraction step are not needed, and the method is suitable for base-level field screening.

The invention discloses an enzyme signal amplified mycobacterium rapid detection kit and a detection method, and relates to the technical field of in vitro diagnosis. Aiming at the current situations that a culture method is time-consuming, PCR (Polymerase Chain Reaction) equipment is expensive and a rapid detection strip is low in sensitivity, the invention provides an enzyme signal amplified mycobacterium rapid detection kit and a detection method, an upper cover and a lower cover of a shell are buckled to form a cavity, a chromatography strip assembly is attached to a PVC (Polyvinyl Chloride) back plate in the cavity, the assembly is formed by sequentially overlapping a sample adding pad, a combining pad, an NC (Nitrocellulose) membrane and an absorbing pad, and a T line and a C line are arranged on the NC membrane; an HRP labeled antibody is pre-embedded in the conjugate pad, and after detection, a chromogenic substrate is dropwise added to trigger multiple rounds of enzymatic reaction amplification signals. The structure is matched with an annular sealing ring and a drying agent, interpretation can be performed by naked eyes or a reading instrument within 15 min, the lowest detection limit reaches 10-12 CFUmL, the false negative risk of low bacterial quantity is reduced, and the rapid screening requirement of a basic level site is met.

The invention discloses a site switching method and device, electronic equipment and a storage medium, and relates to the technical field of cloud computers, and the method comprises the steps: obtaining a plurality of indexes of a main site, each index being used for indicating a hardware resource occupation state of the main site, a network state of the main site or a service availability state of the main site; when it is detected that at least one abnormal index exists in the multiple indexes, at least one fault corresponding to the at least one abnormal index is determined according to the at least one abnormal index and the duration of each abnormal index; when the at least one fault is a recoverable fault, obtaining a plurality of sessions in the main site and the delay of a transmission path required by each session; and switching the plurality of sessions to one or more alternative sites in batches based on the priorities corresponding to the delays. According to the method and the device, the session on the main site can be switched in time, the service continuity in the switching process is ensured, the rapid identification and switching of the faulty site are further realized, and the high availability of the service is ensured.

The invention relates to the technical field of biological information, in particular to a generic cancer brain metastasis molecular typing system and method and a medium. According to the generic cancer brain metastasis molecular typing system, brain metastasis molecular typing obtained through a data processing and consensus clustering method is kept stable in multiple queues and multiple platforms, and reproducibility and robustness are achieved. The typing system disclosed by the invention can identify four subtypes with consistent biological connotation in general cancer brain metastasis, can realize unified brain metastasis typing across primary parts, and avoids the limitation of typing only depending on primary lesion. The four subtypes correspond to different states such as neuron-like, immune infiltration, metabolic reprogramming and proliferation procedures and can be consistently verified on the proteome / pathway level, and biological interpretation is high. The four types can correspond to prognosis differences, immune / metabolic landscapes and other characteristics, and a basis is provided for risk stratification and potential treatment strategy selection.

To predict the performance impact due to new volume allocation, with high accuracy.SOLUTION: A storage system comprises a primary site that holds a primary volume, and a secondary site that holds a secondary volume and a journal volume. The primary site is configured with one or more nodes. The secondary site is configured with a plurality of nodes. When a management program running on any node or a predetermined management apparatus creates a new secondary volume and a new journal volume on the secondary site, the management program predicts the load of a processor for the new secondary volume under the operating conditions for performing redundancy processing within the secondary site, predicts the load for the new journal volume under the operating conditions for not performing the redundancy processing within the secondary site, and selects a node on which to place a new volume based on the results of load prediction.SELECTED DRAWING: Figure 1

A site and storage tier aware technique replicates data as one or more recovery points (RPs) from a primary site to a secondary site in a multi-site data replication environment. A storage tier aware reference resolver determines (i) an amount of RP data transfer associated with the replication and (ii) location information associated with a cloud storage tier storing the RP data in an object store. The storage tier aware reference resolution aspect provides two additional factors to consider when retrieving data of a reference RP from cloud storage: (iii) the time (duration) needed to retrieve the data and (iv) the cost (financial expense) needed to retrieve the data. In addition, a site aware reference resolution aspect of the technique determines an optimal RP to use as the reference RP and involves consideration of (v) which RPs have been replicated from the primary site to the secondary site and (vi) which RPs have been retained for storage at the sites.

Systems and methods for allowing and maintaining Input / Output (I / O) operations in a distributed storage system with multiple storage sites when communications links between the sites fail are provided. Mirrored storage sites use an update policy, including an update record and a bitmap configured to track changes in memory blocks storing an I / O request. When a link between two or more sites fails, one or more of the sites may be designated as a primary site, on which normal I / O operations may continue. One or more sites may also be designated as non-primary sites and are “detached” with respect to the primary site or sites. I / O operations on the non-primary sites may be suspended until the link is restored. When the link is restored, the update records and bitmaps are used to rebuild the detached sites.