Methyl methacrylate cross-linked polymer microparticle loaded with lipid-soluble sun-screening agent and preparation method of microparticle

Abstract

The invention discloses a methyl methacrylate cross-linked polymer microparticle loaded with a lipid-soluble sun-screening agent and a preparation method of the microparticle. The methyl methacrylate cross-linked polymer microparticle loaded with the lipid-soluble sun-screening agent is of a core-shell structure, wherein the lipid-soluble sun-screening agent serves as a core and a methyl methacrylate cross-linked polymer functions as a shell; and at 25 DEG C, the microparticle is 178.2-1298nm in granularity and is 10.81-51.96% in embedding rate. The preparation method comprises the following steps: dissolving a surfactant in de-ionized water at room temperature to obtain an aqueous phase; uniformly mixing the lipid-soluble sun-screening agent with methyl methacrylate and divinyl benzene so as to obtain an oily phase; mixing, homogenizing and emulsifying the oil phase and the aqueous phase, then adding an initiator and reacting at 30-75 DEG C for 4-8h so as to obtain a reaction liquid; and demulsifying, filtering, cleaning, suction-filtering and drying the reaction liquid so as to obtain the methyl methacrylate cross-linked polymer microparticle loaded with the lipid-soluble sun-screening agent.

Description

technical field [0001] The invention relates to a method for preparing microparticles loaded with a fat-soluble sunscreen, in particular to a methyl methacrylate crosslinked polymer microparticle loaded with a fat-soluble sunscreen and a preparation method thereof. Background technique [0002] The direct exposure of ultraviolet rays in the sun to the skin can cause skin erythema, burns, blackening, dermatitis, make the skin produce oxygen free radicals, accelerate the generation of skin wrinkles, pigmentation, and even a series of skin problems such as skin cancer. The protection against ultraviolet rays can not only effectively protect the naked skin of the human body from direct damage of ultraviolet rays, such as sunburn and acute skin erythema, but also significantly delay the photoaging and tanning of the skin, and effectively reduce the incidence of skin cancer. In recent years, due to the continuous destruction of the ozone layer, the incidence of skin cancer has inc...

AI Technical Summary

Problems solved by technology

Traditional sunscreen cosmetics often use organic compounds as UV absorbers. Their photosensitivity and light damage effects reduce their stability and have a certain stimulating effect on the skin. However, in order to protect the skin from UV rays as much as possible, it is necessary to increase its additive quantity, and this will increase the cost of the product and reduce the safety of the product

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