Microcapsule wrapping solid sun-screening agent, preparation method and application thereof

A technology of microcapsules and sunscreen agents, which can be used in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., and can solve problems such as poor touch feeling.

Active Publication Date: 2013-06-26
ETERNAL CHINA INVESTMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And alleviate the problems of skin i...

Method used

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  • Microcapsule wrapping solid sun-screening agent, preparation method and application thereof
  • Microcapsule wrapping solid sun-screening agent, preparation method and application thereof
  • Microcapsule wrapping solid sun-screening agent, preparation method and application thereof

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preparation example Construction

[0072] Microcapsule preparation method of the present invention, comprises the following steps:

[0073] (a) dissolving the natural polymer in water or an aqueous solution to form a solution;

[0074] (b) dispersing the solid sunscreen in the solution obtained in step (a) to form an S / W dispersion, or heating and melting the solid sunscreen into a liquid, and dispersing it in the solution obtained in step (a) to form an O / W emulsion;

[0075] (c) dispersing the S / W dispersion liquid or O / W emulsion that step (b) obtains in the oily phase that contains lipophilic surfactant to form S / W / O emulsion or O / W / O emulsion;

[0076] (d) curing the S / W / O emulsion or O / W / O emulsion obtained in step (c) to obtain the microcapsules.

[0077] The natural polymer described in step (a), the solid sunscreen agent described in step (b) are as described above.

[0078] In step (a), the aqueous solution refers to the solution formed by acid and water, alkali and water, salt and water or polymer ...

Embodiment 1

[0099] Add 0.3 g of deacetylated chitosan (deacetylation degree 89%) to 20 g of 1 wt% acetic acid aqueous solution, stir at 200 RPM for 30 min to fully dissolve it for later use.

[0100] Add 5g of 2-(2'-hydroxyl-5'-methylphenyl)benzotriazole (UV360) and 0.017g of polyvinyl alcohol PVA (polymerization degree 1750) into the deacetylated chitosan solution for subsequent dissolution , and then stirred at room temperature and 1000 RPM for 10 min to obtain a S / W dispersion.

[0101] The mixed liquid 50g (Span80 accounts for 4wt% of olive oil weight) of olive oil and Span80 is standby as the oil phase containing lipophilic surfactant.

[0102] The above S / W dispersion was added to the olive oil oil phase containing the lipophilic surfactant Span80, and stirred at room temperature and 1000 RPM for 60 min to obtain the S / W / O emulsion. Then add dropwise 3.75×10 -3 g (the molar ratio of amino group to aldehyde group is 1:1) 1wt% glutaraldehyde aqueous solution, cross-linking reaction ...

Embodiment 2

[0105] Add 0.8 g of agar into 20 g of water, heat in an oil bath at 110° C. for 30 min to fully dissolve it, and then set aside at 95° C. for later use.

[0106] Mix 5g of organic ultraviolet absorber butylmethoxydibenzoylmethane (Parsol1789) and 0.3g Tween80 at 95°C, add to the above-mentioned dissolved agar solution, and then stir at 95°C and 1000RPM for 10min to obtain O / W lotion.

[0107] Preheat 50 g of the liquid paraffin and PO-500 mixed liquid (PO-500 accounts for 0.5 wt% of the liquid paraffin weight) to 95° C. as an oil phase containing lipophilic surfactant for later use.

[0108] The above O / W emulsion was added into the oil phase containing lipophilic surfactant, and stirred at 95° C. and 1000 RPM for 60 min to obtain an O / W / O emulsion.

[0109] The O / W / O emulsion was slowly stirred at 200RPM for 60min, cooled down to room temperature and solidified, and then filtered with suction and washed with distilled water.

[0110] The photomicrograph of the prepared mic...

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Abstract

The invention discloses a microcapsule wrapping a solid sun-screening agent, a preparation method and application thereof. The microcapsule comprises the solid sun-screening agent and a natural polymer. The solid sun-screening agent is wrapped in the microcapsule formed by the natural polymer. The solid sun-screening agent is an inorganic ultraviolet screener, an organic ultraviolet adsorbent or a mixture of the inorganic ultraviolet screener and the organic ultraviolet adsorbent. The natural polymer is agar, agarose, cellulose, chitosan or a derivative thereof. The microcapsule provided by the invention can be used in cosmetic to effectively prevent the solid sun-screening agent from being decomposed, and the sun-screening agent is separated from skin, so that irritation to skin is reduced. Hydrophilic natural polymer can cover color, improve feel and enhance cooperation in cosmetic.

Description

technical field [0001] The invention relates to microcapsules, in particular to a microcapsule for wrapping a solid sunscreen, a preparation method and an application thereof. Background technique [0002] Humans have long recognized that long-term exposure to ultraviolet (wavelength 280-400nm) radiation can cause damage to the skin, such as UV-B with a wavelength between 280-320nm can cause erythema or even burns on the skin, and UV-B with a wavelength between 320-400nm UV-A will accelerate the loss of skin elasticity, lead to premature skin aging and wrinkles, and even promote the initiation or expansion of erythema reaction. [0003] The chemicals currently used for sun protection can be divided into two types: UV absorbers and UV shielding agents according to the mechanism of sun protection. UV absorbers are usually lipophilic liquids or solids, and the hydroxyl hydrogen on the benzene ring in the molecule is between the adjacent carbonyl oxygen. Intramolecular hydrogen...

Claims

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Application Information

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IPC IPC(8): A61K8/11A61K8/73A61K8/27A61K8/29A61K8/35A61K8/37A61K8/49A61K8/92A61K8/89A61Q17/04
Inventor 周青竹赵平卜诗尧
Owner ETERNAL CHINA INVESTMENT
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