Method for preparing synergistic sunscreen micron capsule by virtue of composite condensation

A complex coagulation and encapsulation technology, applied in the field of preparation of synergistic sunscreen microcapsules, can solve the problems of sunscreen damage, large amount of sunscreen, limited sunscreen effect of sunscreen, etc., and achieves low price, high sunscreen effect and good biological phase. capacitive effect

Inactive Publication Date: 2018-12-11
HUIZHOU RES INST OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies in the use of sunscreens currently on the market, and provide a synergistic sunscreen microcapsule and its preparation method, in order to solve the damage caused by direct contact of sunscreens with the skin, the limited sunscreen effect of sunscreens, and the large amount of sunscreens on the market And other issues

Method used

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  • Method for preparing synergistic sunscreen micron capsule by virtue of composite condensation
  • Method for preparing synergistic sunscreen micron capsule by virtue of composite condensation
  • Method for preparing synergistic sunscreen micron capsule by virtue of composite condensation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh Arabic gum to prepare 1% gum Arabic solution, take 15 mL of gum Arabic solution in a beaker, put it in a water bath at 50 °C and add it. Weigh the sodium caseinate solution to prepare 1% sodium caseinate solution. Weigh octyl methoxycinnamate so that the ratio of wall material to core material is 1:1, add 15 mL of sodium caseinate solution, homogenize for 5 min, and rotate at 10,000 rpm. Add the homogenized emulsion into the gum arabic solution, control the stirring speed to 500 rpm, quickly add glacial acetic acid to adjust the pH to 2.5, and react for 10 minutes. The solution was taken out, stirred and cooled to room temperature, then 1% glutaraldehyde was added, and reacted for 30 minutes. The reacted solution is left to stand, separated into layers, and the supernatant is precipitated, and the precipitate is freeze-dried to obtain synergistic sunscreen microcapsules.

Embodiment 2

[0028] Weigh arabic gum to prepare 0.5% gum arabic solution, take 15 mL gum arabic solution in a beaker, put it in a water bath at 50 °C and add it. Weigh the sodium caseinate solution to prepare 0.5% sodium caseinate solution. Weigh octyl methoxycinnamate so that the ratio of wall material to core material is 1:2, add 15 mL sodium caseinate solution, homogenize for 5 min, and rotate at 10000 rpm. Add the homogenized emulsion into the gum arabic solution, control the stirring speed to 500 rpm, quickly add glacial acetic acid to adjust the pH to 2.5, and react for 10 minutes. The solution was taken out, stirred and cooled to room temperature, then 1% glutaraldehyde was added, and reacted for 30 minutes. The reacted solution is left to stand, separated into layers, and the supernatant is precipitated, and the precipitate is freeze-dried to obtain synergistic sunscreen microcapsules.

Embodiment 3

[0030] Weigh Arabic gum to prepare 1.5% gum Arabic solution, take 15 mL of gum Arabic solution in a beaker, put it in a water bath at 50 °C and add it. Weigh the sodium caseinate solution to prepare a 1.5% sodium caseinate solution. Weigh octyl methoxycinnamate so that the ratio of wall material to core material is 2:1, add 15 mL of sodium caseinate solution, homogenize for 5 min, and rotate at 10,000 rpm. Add the homogenized emulsion into the gum arabic solution, control the stirring speed at 500 rpm, quickly add glacial acetic acid to adjust the pH to 2.8, and react for 10 minutes. The solution was taken out, stirred and cooled to room temperature, then 1% glutaraldehyde was added, and reacted for 30 minutes. The reacted solution is left to stand, separated into layers, and the supernatant is precipitated, and the precipitate is freeze-dried to obtain synergistic sunscreen microcapsules.

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Abstract

The invention discloses a method for preparing a synergistic sunscreen micron capsule by virtue of composite condensation. The method comprises the following steps: (1) preparing sodium caseinate solution with pH of 6-8; (2) preparing Arabic gum solution with pH of 6-8; (3) adding a core material, the mass ratio of the core material to a wall material being 1:1; (4) shearing with a high-speed shearing machine to form uniform and milk white emulsion; (5) dropwise adding the emulsion in step (4) into the solution in step (2), wherein, pH is 2.3-3.0, and reacting at 30-50DEG C; (6) cooling the solution in step (5) to room temperature; (7) adding a curing agent, and controlling the curing temperature to 10-30DEG C to obtain the sunscreen micro capsule; (8) standing and precipitating the obtained product to separate out supernate; and (9)freezing and drying the precipitate obtained in step (8) to obtain the synergistic sunscreen micron capsule. The wall material selected by the invention isa natural macromolecule compound having an ultraviolet adsorption effect, sodium caseinate is abundant in nature and cheap in price and has good biocompatibility. The sunscreen effect of the synergistic sunscreen micron capsule is higher than that of a sun-screening agent.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and in particular relates to a preparation technology of synergistic sunscreen microcapsules. Background technique [0002] Ultraviolet (UV) in sunlight is mainly divided into three bands, namely short-wave UVC (200-280nm), medium-wave UVB (280-320nm) and long-wave UVA (320-400nm). Short-wave UVC has the weakest penetrating power and is almost completely absorbed by the atmosphere, while medium- and long-wave UVA and UVB can penetrate clouds and the ozone layer to reach the ground surface, causing damage to people's skin. The lesions of the epidermis and superficial dermis of human skin are mainly caused by UVB. UVB can cause DNA damage of keratinocytes, resulting in dysplasia of keratinocytes, disappearance of epidermal protrusions, and inflammatory reactions. In addition, UVB can also greatly accelerate the proliferation of skin melanocytes, and its blackening effect is even higher than 15 times ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/11A61K8/64A61K8/73A61K8/37A61Q17/04
CPCA61K8/11A61K8/37A61K8/64A61K8/73A61K2800/412A61K2800/592A61Q17/04
Inventor 纪红兵徐春涛曾雪敏李有梅
Owner HUIZHOU RES INST OF SUN YAT SEN UNIV
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