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Composition for treating dental caries and method for preparing fluorapatite by using same

A composition and caries technology, applied in the field of biological materials for dental restoration, can solve problems such as fracture and fall off of fillings, and achieve the effect of high chemical stability

Inactive Publication Date: 2010-10-13
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This restoration method can restore the shape and function of the tooth tissue in the short term, but due to the shrinkage and aging of the material, secondary caries often occurs in the long term, or the filling body breaks and falls off.
However, for enamel caries that are not suitable for cavity preparation in the early stage, or some carious lesions that cannot obtain resistance or retention, it is not suitable to use the above materials for filling

Method used

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  • Composition for treating dental caries and method for preparing fluorapatite by using same
  • Composition for treating dental caries and method for preparing fluorapatite by using same
  • Composition for treating dental caries and method for preparing fluorapatite by using same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] Mix 1.33 grams of tetracalcium phosphate and 0.16 grams of ammonium fluoride evenly, then add 0.196 grams of phosphoric acid and 4 mL of water to the mixture, and mix them evenly in the mixing pan with a key to form a cement slurry, and place it at 37 ° C, 100 % humidity environment for 3 days, the obtained material was characterized by XRD, IR and EDS for its chemical structure and composition, the results are as follows Figure 1-Figure 3 shown. It can be seen from the XRD pattern that the prepared product has its characteristic peaks around 2θ=26°, 2θ=32°, 2θ=34°, 2θ=40°, 2θ=47°, and 2θ=50°. The results show that the synthesized product is fluorapatite. It can be seen from the IR spectrum: at 1070cm -1 and 950cm -1 PO 4 3- the absorption peak. at 1432 and 1750.8cm -1 Two absorption peaks at and from 2800cm -1 to 3472cm -1 The absorption peaks between them are the hydroxyl absorption peaks of water. The vibration peak of the P-O-H bond of apatite is at 877.7...

example 2

[0030] Mix 2.66g of tetracalcium phosphate and 0.16g of ammonium fluoride evenly, then add 0.196g of phosphoric acid and 4mL of water into the mixture, and mix evenly in the mixing pan with a key to form a cement paste, which is filled into carious tooth enamel At the defect, the tooth was placed in an environment of 37° C. and 100% humidity for 3 days to obtain an experimental sample. Use SEM to characterize the microstructure of the material surface, such as Figure 4shown. From the SEM photo, it can be seen that fluoroapatite and enamel form a tight bond, and there is no obvious gap on the interface, which can also indicate that the restorative material fluoroapatite and enamel have similar components, making them easy to bond together. Synthetic fluoroapatite is needle-like crystals that are tightly bound together. Cut the material together with the tooth from the center of the material to observe the interface between the material and the surface of the enamel defect, ...

example 3

[0032] Mix 13.3 grams of tetracalcium phosphate and 1.6 grams of ammonium fluoride evenly, then add 1.96 grams of phosphoric acid and 6 mL of water to the mixture, mix evenly in the mixing pan with a key, and mix it into a cement slurry with the key, and fill it into the caries For the enamel defect, place the tooth in an environment of 35-38° C. and 100% humidity for 3 days to obtain fluorapatite.

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Abstract

The invention discloses a composition for treating dental caries, and belongs to the field of biological materials for dental repair. Tetracalcium phosphate, ammonium fluoride and aqueous solution of phosphoric acid are blended to form sludge, the sludge is filled to surfaces of teeth with deep caries and small holes and is cured for 1 to 3 days under the condition of the physiological environment of human bodies to form fluorapatite, so that the coloboma of carious enamel and particularly the large coloboma of the enamel (the deep caries) are repaired. The synthetic fluorapatite and the enamel have the similar chemical components, so the repair materials can be combined with natural enamel directly. The synthetic fluorapatite has a stoichiometric apatite structure, has the high chemical stability (low dissolubility) under the condition of physiological body fluid of the human bodies and releases fluorine slowly under the condition of acidity (during the existence of bacteria), and thus the materials can repair the deep caries and have the effect of caries prevention.

Description

technical field [0001] The invention belongs to the field of biological materials for dental restoration, and in particular relates to a medical material for repairing carious tooth enamel defect. Background technique [0002] Dental caries (dental caries) is a progressive lesion of dental hard tissue caused by the compound action of various factors in the oral cavity. It is the main common disease of the oral cavity, and it is characterized by high incidence and wide distribution. The World Health Organization has listed it together with cancer and cardiovascular disease as the three major human diseases. According to the national oral epidemiological survey report, the prevalence rate of dental caries among Chinese residents is 50%, and that of deciduous teeth is 80%. According to survey statistics, the total number of caries in my country is as high as more than 2 billion, and more than 90% of these caries have not received treatment. Recent survey data in the United St...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/033A61K6/838
Inventor 魏世成魏杰刘晓晨王成洁张翼飞
Owner PEKING UNIV
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