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Bone cement formula and bioresorbable hardened bone cement composites prepared with the same

A composite material and bone cement technology, which can be used in tissue regeneration, surgical adhesives, medical science, etc., and can solve problems such as prolonging setting time.

Active Publication Date: 2012-05-16
NAT CHENG KUNG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the calcium phosphate (CPC) pastes described in U.S. Patent No. 4,612,053 generally require prolonged setting times

Method used

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  • Bone cement formula and bioresorbable hardened bone cement composites prepared with the same
  • Bone cement formula and bioresorbable hardened bone cement composites prepared with the same
  • Bone cement formula and bioresorbable hardened bone cement composites prepared with the same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] Preparation of TTCP powder

[0045] TTCP powder adopts the method proposed by Brown and Epstein [Journal of Research of the National Bureau of Standards-A Physics and Chemistry 6 (1965) 69A 12], from dicalcium pyrophosphate (Ca 2 P 2 o 7 ) (Sigma Chem.Co., St.Louis, MO, USA) and calcium carbonate (CaCO 3 ) (Katayama Chem.Co., Japan, Tokyo) reaction and self-made.

[0046] TTCP powder by adding Ca 2 P 2 o 7 Powder with CaCO 3 The powder was prepared by uniform mixing for 12 hours. Ca 2 P 2 o 7 Powder with CaCO 3 The mixing ratio of the powders was 1:1.27 (weight ratio), and the powder mixture was heated to 1400° C. to react the two powders to form TTCP.

[0047] Preparation of TTCP / DCPA / CSH Composite Paste

[0048] Mix an appropriate amount of TTCP and DCPA powder uniformly in a ball mill, and then uniformly mix with an appropriate amount of CSH powder. Mix the obtained TTCP / DCPA / CSH mixed powder with the desired coagulation solution (for example, 0.6M (NH ...

Embodiment 1

[0085] Embodiment 1: (TTCP / DCPA) / CSH cement and various coagulation solutions

[0086] Table 5: 75 wt% phosphate (TTCP / DCPA) / 25 wt% CSH composite cement

[0087]

[0088]

[0089] The data shown in Table 5 can be summarized as follows:

[0090] 1. K 2 HPO 4 - WT / ST of derived hardened cement composites is too short and CS is low.

[0091] 2. (NH 4 )H 2 PO 4 - Derived hardened cement composites have reasonable WT / ST, but disperse after immersion in Hanks' solution.

[0092] 3. NaH 2 PO 4 2H 2 O-derived hardened cement composites have reasonable WT / ST, but are too acidic and have low strength.

[0093] 4. In all coagulation solutions tested, (NH 4 ) 2 HPO 4 Generate the highest CS.

[0094] 5. In all (NH 4 ) 2 HPO 4 Among the concentrations, 0.6M gives the highest CS (41MPa).

Embodiment 2

[0095] Embodiment 2: with 0.60M (NH 4 ) 2 HPO 4 Mixed TTCP / DCPA / CSH

[0096] Table 6: and 0.60M (NH 4 ) 2 HPO 4 Mixed TTCP / DCPA / CSH

[0097]

[0098]

[0099] In Table 6 (with 0.60M (NH 4 ) 2 HPO 4 Summary of results shown in Mixed TTCP / DCPA / CSH):

[0100] (1) When the CSH content in TTCP / DCPA / CSH cement powder is higher than about 65 wt%, its CS value becomes too low ( 30 MPa), the CSH content should be less than about 35% by weight.

[0101] (2) When 0.60M (NH 4 ) 2 HPO 4 When used as a sclerosing solution, all cytotoxicity values ​​were acceptably greater than 80% for all CSH contents (from about 10% to about 90% by weight).

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Abstract

The present invention provides a bone cement formula having a powder component and a setting liquid component, wherein the powder component includes a calcium sulfate source and a calcium phosphate source with a weight ratio of the calcium sulfate source less than 65%, based on the total weight of the calcium sulfate source and the calcium phosphate source, and the setting liquid component comprises ammonium ion (NH4+) in a concentration of about 0.5 M to 4 M, wherein the calcium phosphate source includes tetracalcium phosphate (TTCP) and dicalcium phosphate in a molar ratio of TTCP to dicalcium phosphate of about 0.5 to about 2.5, and the calcium sulfate source is calcium sulfate hemihydrate (CSH), calcium sulfate dehydrate (CSD), or anhydrous calcium sulfate.

Description

technical field [0001] Exemplary embodiments of the present invention relate to bone repair substances for use in medicine. More specifically, exemplary embodiments of the present invention relate to a bone cement formula. Background technique [0002] Bone cement compositions are widely used to bond, fill and / or repair damaged natural bone. Bone cements are commonly used in orthopedic, dental procedures and / or other medical applications. Although having many advantages such as excellent biocompatibility, excellent osteoconductivity, and enhanced mechanical or physical strength, most calcium phosphates exhibit a clinically low bioresorption rate. On the other hand, compounds of calcium sulphate also exhibit a relatively high dissolution rate, which is usually too high for many applications in order to allow rapid growth of new bone cells in the bone cavity. Composite materials containing calcium sulfate generally have lower mechanical and / or physical strength than composi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B28/34A61L27/12
CPCC04B28/34C04B28/346A61L2430/02C04B2111/00836A61L24/0063C04B41/5092A61L27/46C04B41/009C04B22/062C04B22/143C04B22/16C04B24/06C04B38/02
Inventor 陈瑾惠朱建平
Owner NAT CHENG KUNG UNIV
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