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Preparation method of high-performance modified tetracalcium phosphate 3D (three-dimensional) printing material for biomedicine

A tetracalcium phosphate, biomedical technology, applied in the field of 3D printing materials, can solve the problems of difficult to achieve chemical balance, low porosity and mechanical strength, slow chemical reaction, etc., to reduce energy consumption, cost reduction, mechanical The effect of excellent mechanical properties

Inactive Publication Date: 2019-06-21
ZHONGSHAN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to achieve a theoretical chemical equilibrium under actual preparation conditions, mainly because the chemical reactions between solid phase substances proceed slowly.
Therefore, in order to improve the purity of tetracalcium phosphate, the roasting temperature in the prior art process must be as high as 1500°C, and the roasting time is at least 10h; but even so, the purity of tetracalcium phosphate is generally lower than 90%, and the porosity and mechanical strength It is not high, which fundamentally restricts the application of tetracalcium phosphate and even CPC in clinical medicine

Method used

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  • Preparation method of high-performance modified tetracalcium phosphate 3D (three-dimensional) printing material for biomedicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepare modified tetracalcium phosphate 3D printing material, the steps are:

[0036] (1) First, 1 part of Ce(NO 3 ) 3 , Add 50 parts of magnesium chloride to 500 parts of pure water and stir well; then slowly add 0.1moL·L -1 NaOH solution until the system pH ≥ 10, then add 30 parts of silica sol (SiO 2 Colloid concentration is 20%) and slowly add 0.1moL·L -1 Dilute sulfuric acid solution until the pH of the system is less than or equal to 7; then raise the temperature to 160°C and keep it warm for 2 hours; then stop the reaction and discharge the material, filter the reaction solution and wash it thoroughly, and then fully dry the filter cake at 80°C to obtain positively charged silicon Acid magnesium aluminum additive;

[0037] (2) Next, mix calcium carbonate and calcium hydrogen phosphate dihydrate according to the molar ratio of Ca:P=2:1, and then add the positively charged magnesium aluminum silicate auxiliary agent prepared in step (1) (the dosage is calcium c...

Embodiment 2

[0039] Prepare modified tetracalcium phosphate 3D printing material, the steps are:

[0040] (1) First, 2 copies of Ce 2 (SO 4 ) 3 , 3 copies of Dy(NO3 ) 3 , 40 parts of magnesium sulfate and 40 parts of magnesium nitrate are added to 500 parts of pure water and fully stirred evenly; then slowly add 0.5moL·L -1 KOH+0.5moL·L -1 Mix dilute alkali solution with NaOH until the system pH ≥ 10, then add 30 parts of silica sol (SiO 2 Colloid concentration is 20%) and 30 parts of silica sol (SiO 2 Colloid concentration is 30%), and slowly add 0.5moL·L -1 Sulfuric acid+0.5moL·L -1 Mix dilute acid solution with hydrochloric acid until the pH of the system is less than or equal to 7; then raise the temperature to 200°C and keep it warm for 4 hours; then stop the reaction and discharge the material, filter the reaction solution and wash it thoroughly, and then fully dry the filter cake at 95°C to obtain positive Charged magnesium aluminum silicate additive;

[0041] (2) Next, cal...

Embodiment 3

[0043] Prepare the modified tetracalcium phosphate 3D printing material, the steps are:

[0044] (1) First, 1 part of CeCl 3 , 1 Dy 2 (SO 4 ) 3 , 1 part of Sr(NO 3 ) 2 , 20 parts of magnesium chloride, 15 parts of magnesium sulfate, and 30 parts of magnesium nitrate are added to 500 parts of pure water and fully stirred evenly; then slowly add 0.2moL·L -1 KOH+0.3moL·L -1 NaOH+0.1moL·L -1 Mix ammonia water with dilute alkali solution until the pH of the system is ≥ 10, then add 10 parts of silica sol (SiO 2 Colloidal concentration is 20%), 10 parts of silica sol (SiO 2 Colloid concentration is 23%), 10 parts of silica sol (SiO 2 Colloid concentration is 25%), and slowly add 0.2moL·L -1 Sulfuric acid+0.3moL·L -1 Hydrochloric acid+0.1moL·L -1 Mix dilute acid solution with phosphoric acid until the pH of the system is less than or equal to 7; then raise the temperature to 170°C and keep it warm for 3 hours; then stop the reaction and discharge the material, filter the ...

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Abstract

The invention discloses a preparation method of a high-performance modified tetracalcium phosphate 3D (three-dimensional) printing material for biomedicine. According to the method, rare earth materials, silica sol, soluble magnesium salt and the like serve as raw materials, a positive charge magnesium aluminum silicate additive is prepared through high-temperature hydrothermal reaction, high-temperature solid-phase reaction among the additive, calcium sources and phosphorus sources is implemented to prepare a high-purity tetracalcium phosphate powder material, the material can be prepared into a bone material entity finished product with excellent mechanical performances and rich pore structures by a 3D printing mode, and the material has bright industrial application prospects.

Description

[0001] 【Technical field】 [0002] The invention relates to a preparation method of a high-performance biomedical modified tetracalcium phosphate 3D printing material, belonging to the technical field of 3D printing materials. [0003] 【Background technique】 [0004] Human beings have been suffering from orthopedic diseases for a long time, and a large number of patients suffer from orthopedic diseases every year. According to statistics, the annual number of fractures in the United States is about 1 million cases, and the annual bone transplant volume in my country is about 200,000 cases. In order to treat orthopedic diseases, a variety of materials have been used in medicine; and these materials to be implanted into the human body are required to have good biocompatibility, good mechanical properties, and the ability to promote bone tissue regeneration. Humans have successively used natural materials (such as gypsum, etc.) and artificial materials (such as metal alloys, ceram...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/50A61L27/56B33Y70/00
Inventor 聂建华王俊李吉昌李金盛江常胜余明君
Owner ZHONGSHAN POLYTECHNIC
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