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Method for preparing tetracalcium phosphate from natural bone powder

A tetracalcium phosphate, natural bone technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of difficult to achieve large-scale production, difficult to accurately control parameters, high raw material cost, and achieve low cost and low price. , the effect of a wide range of raw materials

Inactive Publication Date: 2008-09-17
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: high cost of raw materials, complex process, difficult to accurately control parameters, and difficult to achieve large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Weigh 13.4 grams of natural hydroxyapatite and 2.7 grams of calcium carbonate, pour them into a 100 ml beaker, add 20 ml of deionized water, stir for 3 hours to mix thoroughly; put them in an oven at 80°C for drying. Take it out after three days, grind it, and put it into an alumina crucible after passing through a 40-mesh sieve.

[0020] 2. Put the crucible into the sintering furnace, raise the temperature to 1400°C at a rate of 4.5°C / min, take out the reaction product after 6 hours of heat preservation, pour ice water into the product powder for rapid cooling, and store it in a dry place to obtain The purity is 99% TTCP product.

Embodiment 2

[0022] 1. Weigh 112 grams of natural hydroxyapatite, natural bone powder, and 22 grams of calcium carbonate, pour it into a 500 ml beaker, add 100 ml of deionized water, stir for 3 hours to mix thoroughly; put it in an oven at 80°C for drying. Take it out after three days, grind it, and put it into an alumina crucible after passing through a 40-mesh sieve.

[0023] 2. Put the crucible into the sintering furnace, raise the temperature to 1500°C at a rate of 4.5°C / min, keep the temperature for 15 hours, take out the reaction product, quench it in the air, and store it in a dry place to obtain a TTCP product with a purity of 100%.

Embodiment 3

[0025] 1. Weigh 16.8 grams of natural hydroxyapatite, natural bone powder and 3.3 grams of calcium carbonate, pour it into a 100 ml beaker, add 30 ml of deionized water, stir for 3 hours and mix thoroughly; put it in an oven at 80°C for drying. Three days later, it was taken out, ground, sieved through a 40-mesh sieve, put into a ball mill jar, and ethanol was used as a medium for ball milling for 3 hours. After drying, it was put into an alumina crucible.

[0026] 2. Put the crucible into the sintering furnace, raise the temperature up to 1500°C at a rate of 10°C / min, keep it warm for 10 hours, take out the reaction product to quench it in ice water, and store it in a dry place to obtain 100% TTCP product.

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Abstract

The invention discloses a method for preparing tetracalcium phosphate by using natural bone powder in biomedical material technical field, comprising following steps: firstly, weighting and mixing the natural bone powder and calcium carbonate powder, the molar ratio of calcium and phosphor being two to two point one, adding the distilled water and mixing up in order to get HAP-CaCO3 suspension, stirring fully until two kinds of powder are mixed evenly and contact completely, putting into an oven and drying, taking out the dried powder, grinding and sieving; secondly, putting the powder into a sintering furnace to calcine at the temperature of one thousand and four hundred DEG C to one thousand and five hundred DEG C, preserving the heat for hours, taking out and cooling in order to get tetracalcium phosphate. The invention has the advantages of using aninial bone powder as raw mateiral, and having simple preparation craft, controllable parameter and high purity of the products obtained.

Description

technical field [0001] The invention relates to a method for preparing ceramic materials in the technical field of biomedical materials, in particular to a method for preparing high-purity tetracalcium phosphate by using natural bone powder. Background technique [0002] In recent years, bioceramic materials, especially calcium phosphate bioceramic materials, including hydroxyapatite (HAP), tricalcium phosphate (Ca 3 (PO 4 ) 2 , α-TCP and β-TCP) and tetracalcium phosphate (Ca 4 (PO 4 ) 2 O, TTCP), etc., because the composition of this kind of material is very close to the inorganic composition of human bone, so it shows excellent biocompatibility, and has good biodegradability and osteoinductive performance at the same time, therefore, in the field of biological bone repair application is becoming more and more widespread. In the mid-1980s, American Brown and Chow invented calcium phosphate bone cement (CPC), which was composed of solid phase and liquid phase. In addit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 孙康李万万余晓鸣陈高祥
Owner SHANGHAI JIAO TONG UNIV
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