Calcium phosphate bone repair material and preparation method thereof

Abstract

The invention relates to a calcium phosphate bone repair material and a preparation method thereof. The calcium phosphate bone repair material is formed by mixing a solid phase with a liquid phase, wherein the solid phase comprises tetracalcium phosphate or monocalcium phosphate monohydrate and active calcium phosphate auxiliarily prepared under the support of microwaves; and the liquid phase is any one or more than one of the following liquid materials: distilled water, normal saline, simulated body fluid, dihydrogen phosphate solution, hydrogen phosphate solution, phosphate buffer solution, bicarbonate solution and citric acid solution. The preparation method comprises a step of preparing active calcium phosphate under the support of microwaves; a step of uniformly mixing active calcium phosphate with tetracalcium phosphate or monocalcium phosphate monohydrate to prepare a solid phase; a step of preparing a liquid phase; and a compounding step of rapidly mixing the solid-phase ingredients with the liquid-phase solution and uniformly stirring to obtain the calcium phosphate bone repair material. The calcium phosphate bone repair material disclosed by the invention is remarkably improved in terms of mechanical properties, brittleness, setting time and degradation property, has good biocompatibility, is injectable, and capable of being used for bone tissue damage repair.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a calcium phosphate bone repair material and a preparation method thereof technical background [0002] At present, the commonly used bone repair materials include autologous bone, allogeneic bone and artificial synthetic materials, but these materials are deficient to varying degrees and cannot meet clinical needs. For example, although autologous bone transplantation has no immune rejection and has a good repair effect, the material obtained is very limited and causes bone defects in the donor site; allogeneic bone transplantation is likely to cause immune rejection, poor repair effect, and the risk of infectious viral diseases ; Synthetic materials such as polymethyl methacrylate, vulcanized silicone rubber, etc. are non-degradable materials and cannot repair the defect area. [0003] Brown and Chow of the United States discovered the hydration and hardening prop...

AI Technical Summary

Problems solved by technology

However, there are also disadvantages such as low strength, slow curing, poor water resistance, and low degradation rate, which affect its clinical application.