31 results about "3-Hydroxypropionate" patented technology

Several novel PHA polymer compositions produced using biological systems include monomers such as 3-hydroxybutyrate, 3-hydroxypropionate, 2-hydroxybutyrate, 3-hydroxyvalerate, 4-hydroxybutyrate, 4-hydroxyvalerate and 5-hydroxyvalerate. These PHA compositions can readily be extended to incorporate additional monomers including, for example, 3-hydroxyhexanoate, 4-hydroxyhexanoate, 6-hydroxyhexanoate or other longer chain 3-hydroxyacids containing seven or more carbons. This can be accomplished by taking natural PHA producers and mutating through chemical or transposon mutagenesis to delete or inactivate genes encoding undesirable activities. Alternatively, the strains can be genetically engineered to express only those enzymes required for the production of the desired polymer composition. Methods for genetically engineering PHA producing microbes are widely known in the art (Huisman and Madison, 1998, Microbiology and Molecular Biology Reviews, 63: 21-53). These polymers have a variety of uses in medical, industrial and other commercial areas.

Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are useful for the production of PHAs. In some cases one or more of these genes are native to the host organism and the remainder are provided from transgenes. These organisms produce poly (3-hydroxyalkanoate) homopolymers or co-polymers incorporating 3-hydroxypropionate or 3-hydroxyvalerate monomers wherein the 3-hydroxypropionate and 3-hydroxyvalreate units are derived from the enzyme catalysed conversion of diols. Suitable diols that can be used include 1,2-propanediol, 1,3 propanediol and glycerol. Biochemical pathways for obtaining the glycerol from normal cellular metabolites are also described. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates including 1,3-propanediol, 3-hydroxypropionaldehyde, acrylics, malonic acid, esters and amines.

The invention relates to the field of hydrogenation catalysts, in particular to a catalyst for hydrogenation preparation of 1,3-propanediol from methyl 3-hydroxypropionate and a preparation method of the catalyst. The catalyst for hydrogenation preparation of 1,3-propanediol from methyl 3-hydroxypropionate is characterized in that SiO2 serves as a carrier, a Cu-based catalyst is adopted, one or more of the elements of Zn, Zr, Mn, La, P, Mo and Ni are added to serve as auxiliaries, and the catalyst comprises, by mass, 45%-75% of CuO, 15%-45% of SiO2 and 0.1%-25% of auxiliaries. The obtained catalyst is small in particle size, high in dispersity of active components and large in specific surface area; when the catalyst is used for hydrogenation preparation of 1,3-propanediol from methyl 3-hydroxypropionate, the activity and selectivity are high, and the repeatability is good.

The invention relates to the technical field of catalysts, in particular to a catalyst for hydrogenating 3-hydroxypropionate to prepare 1,3-propanediol and a preparation method thereof. The catalyst of the present invention is composed of CuO, ZnO, P and SiO2 four components, and the weight percentage of each component is CuO 25%~60%, ZnO 1%~30%, P 0.01%~10%, SiO2 30%~60% %, the total amount of the four components satisfies 100%. The preparation method of the catalyst is to first complex the copper salt and the ammonium salt and then blend them with a salt solution containing a certain amount of Cu and Zn, then add ammonium hypophosphite and silica sol in turn, and undergo aging, filtration, drying, molding, and high-temperature roasting. The obtained catalyst can be used to hydrogenate 3-hydroxy propionate to prepare 1,3-propanediol after being reduced in a reactor. The catalyst preparation method of the invention is simple and convenient, has long service life, good stability and high selectivity of 1,3-propanediol.

The invention relates to a method for preparing methyl 3-hydroxypropionate from ethylene oxide. According to the method, Co2(CO)8 is used as a catalyst, and one selected from nitrogen-containing heterocyclic compounds such as pyridine, pyrimidine, imidazole, triazole, tetrazole and purine is used as an auxiliary agent. The method provided by the invention has the advantages of cheap raw materials, mild reaction and short reaction time; and the nitrogen-containing heterocyclic compounds substantially improve the conversion of ethane and the selectivity of 3-HPE in alkoxycarbonylation of ethylene oxide catalyzed by Co2(CO)8.

The invention relates to an esterification reaction-pervaporation membrane separation integrated method for producing methyl 3-hydroxypropionate. The method comprises a process of performing esterification reaction between methanol and 3-hydroxypropionic acid to generate methyl 3-hydroxypropionate, wherein the process comprises the following steps: (1) mixing 3-hydroxypropionic acid and methanol in an esterification reactor, heating, then adding a catalyst, and reacting; and (2) pumping the obtained reaction solution into a pervaporation membrane separation device, dewatering the reaction liquid through the membrane, circularly returning the reaction solution into the esterification reactor, and further performing esterification reaction, thus obtaining the high-purity methyl 3-hydroxypropionate product after the esterification reaction is completed. According to the method provided by the invention, the area of the used membrane is small, the raw material solution/catalyst mass ratio and the reaction temperature are low, the purity and yield of methyl 3-hydroxypropionate can be greatly increased, the process is simple, and the course is stable. Thus, the invention can be easily used in the large-scale production of methyl 3-hydroxypropionate.

The invention provides an application of a poly(ionic liquid) as an auxiliary agent in a carbonyl-methyl esterification reaction of ethylene oxide to prepare methyl 3-hydroxypropionate. The poly(ionic liquid) can not only be used for improving the conversion ratio of ethylene oxide and the selectivity of methyl 3-hydroxypropionate, but also can be recovered through simple centrifugalization and separation after a catalytic reaction. The method improves the purity of a product, shortens the product purification flow and lowers the cost.

There is described a method for producing 3-hydroxypropanal, the method comprising: culturing an Acetobacter lovaniensis bacterium in a growth medium containing phosphate at a level which is more than 1 g/litre and nitrate at a level which is more than 0.1 g/litre, wherein culturing of the bacterium produces the 3-hydroxypropanal. The 3-hydroxypropanal can be separated from the growth medium or, when the microorganism has converted some or all of the 3-hydroxypropanal to 3-hydroxypropionic acid and/or a 3-hydroxypropionate ester, it may be separated as 3-hydroxypropionic acid or a 3-hydroxypropionate ester. The separated product can be converted into other chemicals such as an ester of 3-hydroxypropionic acid, 3-hydroxypropionic acid, 3-hydroxypropionate salts (including ammonium, sodium and calcium 3-hydroxypropionate), acrylic acid, acrylates, acrylamide, acrylonitrile, acrolein and 1,3 propanediol.

The invention relates to a method for preparing 3-hydroxypropionate and mainly aims to solve the problem that in the prior art, a catalyst in a homogeneous system is hard to separate. The method for preparing 3-hydroxypropionate comprises the steps that first, a ligand and cobalt carbonyl are subjected to a coordination reaction in an alcoholic solvent to obtain turbid liquid of a catalyst; second, ethylene oxide and carbon monoxide are added, and a reaction is carried out to obtain 3-hydroxypropionate. According to the technical scheme that the ligand is an acrylonitrile homopolymer or a copolymer which contains acrylonitrile monomer units, the technical problem is well solved, and the method can be applied to industrial production of 3-hydroxypropionate.

The invention relates to the technical field of plastic preparation, and particularly relates to a catalyst for producing 1,3-propanediol through hydrogenation of methyl 3-hydroxypropionate, and preparation method of the catalyst. The catalyst is prepared from the following components in percentage by weight: 40-70% of CuO, 1-20% of ZrO2, 0.5-5% of ZnO, and 18-40% of SiO2. The preparation method comprises the following steps: firstly, according to proportion, dissolving precursors of Cu, Zr and Zn elements into deionized water and evenly mixing, separately dissolving Si precursor into deionized water, then coprecipitating alkaline precipitator under stirring condition at special rate, aging, washing and drying, then baking, tableting and forming and crushing, sieving with certain meshes to obtain the catalyst. The reaction conditions of the catalyst are mild, the preparation process is simple, the conversion rate and yield for preparing 1,3-propanediol through hydrogenation of methyl 3-hydroxypropionate are high, and the repeatability is good.

This invention relates to microorganisms that convert a carbon source to acrylate or other desirable products using propionyl-CoA as an intermediate. The invention provides genetically engineered microorganisms that carry out the conversion, as well as methods for producing acrylate by culturing the microorganisms. Also provided are microorganisms and methods for converting propionyl-CoA and propionate to 3-hydroxypropionyl-CoA, 3-hydroxypropionate (3-HP) and poly-3-hydroxypropionate.

The present invention relates to an acrylic acid ester synthesis method. A purpose of the present invention is mainly to solve the problem of low selectivity of acrylic acid ester in the prior art. According to the present invention, by using the acrylic acid ester synthesis method, in the presence of a molecular sieve catalyst, 3-hydroxypropionate is subjected to dehydrating to obtain the acrylic acid ester; and with the technical scheme, the problem in the prior art is well solved, and the method can be used in the industrial production of the acrylic acid ester.