Method for preparing methyl 3-hydroxypropionate from ethylene oxide
A technology of methyl hydroxypropionate and ethylene oxide, applied in the directions of carbon monoxide or formate reaction preparation, chemical instruments and methods, organic compounds/hydrides/coordination complex catalysts, etc., can solve difficult large-scale production , the raw material conversion rate and 3-HPE selectivity are low, and the effect is poor, and the effect of short time, low raw material price and high ethylene oxide conversion rate is achieved.
Inactive Publication Date: 2017-12-01
南京大学扬州化学化工研究院
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Problems solved by technology
However, the effect of using cobalt carbonyl alone as a catalyst is poor, the conversion rate of raw materials and the selectivity of 3-HPE are all low, and it is difficult to be suitable for industrial large-scale production
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0015] 3.4 g ethylene oxide, Co 2 (CO) 8 (1mol%), pyridine (1mol%), 20 mL methanol, carbon monoxide (CO) replacement 3 times, P co =2 MPa, 75 o C for 5 h. The reaction results are shown in Table 1.
Embodiment 2
[0017] 3.4 g ethylene oxide, Co 2 (CO) 8 (1mol%), pyrimidine (1mol%), 20 mL methanol, carbon monoxide (CO) replacement 3 times, P co =2 MPa, 75 o C for 5 h. The reaction results are shown in Table 1.
Embodiment 3
[0019] 3.4 g ethylene oxide, Co 2 (CO) 8 (1mol%), imidazole (1mol%), 20 mL methanol, carbon monoxide (CO) replacement 3 times, P co =2 MPa, 75 o C for 5 h. The reaction results are shown in Table 1.
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The invention relates to a method for preparing methyl 3-hydroxypropionate from ethylene oxide. According to the method, Co2(CO)8 is used as a catalyst, and one selected from nitrogen-containing heterocyclic compounds such as pyridine, pyrimidine, imidazole, triazole, tetrazole and purine is used as an auxiliary agent. The method provided by the invention has the advantages of cheap raw materials, mild reaction and short reaction time; and the nitrogen-containing heterocyclic compounds substantially improve the conversion of ethane and the selectivity of 3-HPE in alkoxycarbonylation of ethylene oxide catalyzed by Co2(CO)8.
Description
technical field [0001] The present invention relates to the use of Co 2 (CO) 8 As a catalyst, nitrogen-containing heterocyclic compounds such as pyridine, pyrimidine, imidazole, triazole, tetrazole and purine are used as auxiliary agents to catalyze the alkoxy-carbonylation reaction of oxirane to prepare methyl 3-hydroxypropionate. Background technique [0002] 1,3-Propanediol (1,3-PDO) is mainly used in the production of new polyester polytrimethylene terephthalate (PTT), and can also be used in the synthesis of various drugs, plasticizers, detergents, emulsifiers and other fine chemicals product. PTT synthesized from 1,3-PDO and terephthalic acid (ester) not only has the chemical stability of polyethylene terephthalate (PET), but also has good resilience and anti-pollution of nylon 6 and nylon 66 It is a new type of polyester fiber with a very wide application prospect. This makes 1,3-PDO have a very large market demand. Currently, 1,3-PDO is prepared by three main pr...
Claims
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Patent Timeline
Login to View More IPC IPC(8): C07C67/37C07C69/675B01J31/20
CPCC07C67/37B01J31/20C07C69/675
Inventor 王怡宁刘玉炳周军陆海孟许波连范以宁
Owner 南京大学扬州化学化工研究院
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