[Problems] The present invention provides a method for efficiently producing a corresponding
amide compound from a
nitrile compound by a reaction using a
nitrile hydratase and a method for producing an
amide-based
polymer excellent in quality from the
amide compound. In addition, the present invention provides a method for more efficiently producing an
acrylamide with higher quality by a microbial catalyst containing a
nitrile hydratase and the like and a method for producing an
acrylamide-based
polymer, which is excellent in
hue, has a good balance between the water
solubility and the high molecular weight and is also excellent in quality, by using the
acrylamide.[Means for Solving the Problems] The method for producing an amide compound of the present invention is characterized in that in a method for producing an amide compound from a nitrile compound in an
aqueous medium in the presence of a catalyst having a
nitrile hydratase activity, the concentration of
benzene in the
aqueous medium is 4.0 ppm or less. In addition, the method for producing an amide-based
polymer of the present invention is characterized by homopolymerizing the amide compound or by copolymerizing the amide compound and at least
unsaturated monomer copolymerizable with the amide compound. Further, the method for producing acrylamide of the present invention is characterized by hydrating
acrylonitrile having a concentration of
acrolein of 1 ppm or less by a microbial
cell containing a
nitrile hydratase or a processed product of the microbial
cell in an
aqueous medium. Furthermore, the method for producing an acrylamide-based polymer of the present invention is characterized by homopolymerizing the acrylamide or by copolymerizing the acrylamide and at least one
unsaturated monomer copolymerizable with the acrylamide.