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Method For Producing Amide Compound

a technology of compound and amide, which is applied in the preparation of carboxylic acid amides, organic chemistry, chemistry apparatus and processes, etc., can solve the problems of not always obtaining sufficient effects, and achieve the effects of high quality, high yield and excellent hu

Inactive Publication Date: 2009-07-02
MITSUI CHEM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0034]According to the first invention, in the reaction using a nitrile hydratase, a corresponding amide compound may be efficiently produced from a nitrile compound by reducing the concentration of benzene in an aqueous medium containing the nitrile compound to the specific value or lower. In addition, an amide-based polymer excellent in hue may be obtained by using the amide compound produced by the above method, under the reaction conditions in which the concentration of benzene is reduced as described.
[0035]Further, according to the second invention, an acrylamide with higher quality may be more efficiently produced by a microbial catalyst containing a nitrile hydratase and the like. Furthermore, according to the second invention, there may be obtained an acrylamide-based polymer that is excellent in hue, has a good balance between the water solubility and the high molecular weight, and is also excellent in quality.

Problems solved by technology

Further, according to the methods described in the background art of the second invention, sufficient effects may not be always obtained from the viewpoints of eliminating a factor that inhibits the catalytic action of a microbial cell containing a nitrile hydratase and the like and efficiently performing hydration of acrylonitrile.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

production example 1-1

[0112]To a reaction vessel was charged an adsorbent of an activated carbon fixed bed containing 1 kg of an activated carbon (internal surface area: 1000 m2 / kg). An acrylonitrile a having a concentration of benzene of 26 ppm was pumped through the adsorbent from the bottom to the top at a flow rate of 200 m / hr at a temperature of 10° C. After the acrylonitrile a passed through the adsorbent, the concentration of benzene in the acrylonitrile was measured to be 4.0 ppm. Hereinafter, the acrylonitrile after the activated carbon absorption treatment is referred to as the acrylonitrile b.

production example 1-2

[0113]Acrylonitrile c having a concentration of benzene of 11 ppm was used as it is.

production example 1-3

[0114]Methacrylonitrile having a concentration of benzene of 8 ppm was used as it is.

Preparation of Microbial Cell

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Abstract

[Problems] The present invention provides a method for efficiently producing a corresponding amide compound from a nitrile compound by a reaction using a nitrile hydratase and a method for producing an amide-based polymer excellent in quality from the amide compound. In addition, the present invention provides a method for more efficiently producing an acrylamide with higher quality by a microbial catalyst containing a nitrile hydratase and the like and a method for producing an acrylamide-based polymer, which is excellent in hue, has a good balance between the water solubility and the high molecular weight and is also excellent in quality, by using the acrylamide.[Means for Solving the Problems] The method for producing an amide compound of the present invention is characterized in that in a method for producing an amide compound from a nitrile compound in an aqueous medium in the presence of a catalyst having a nitrile hydratase activity, the concentration of benzene in the aqueous medium is 4.0 ppm or less. In addition, the method for producing an amide-based polymer of the present invention is characterized by homopolymerizing the amide compound or by copolymerizing the amide compound and at least unsaturated monomer copolymerizable with the amide compound. Further, the method for producing acrylamide of the present invention is characterized by hydrating acrylonitrile having a concentration of acrolein of 1 ppm or less by a microbial cell containing a nitrile hydratase or a processed product of the microbial cell in an aqueous medium. Furthermore, the method for producing an acrylamide-based polymer of the present invention is characterized by homopolymerizing the acrylamide or by copolymerizing the acrylamide and at least one unsaturated monomer copolymerizable with the acrylamide.

Description

TECHNICAL FIELD[0001]The present invention relates to a method for producing an amide compound.[0002]The present invention (the first invention) relates more particularly to methods for producing an amide compound and an amide-based polymer and further more particularly to a method for efficiently producing a corresponding amide compound from a nitrile compound in an aqueous medium by the use of a catalyst having a nitrile hydratase activity, and a method for producing an amide-based polymer of high quality from the amide compound. In addition, the present invention (the second invention) relates more particularly to methods for producing an acrylamide and an acrylamide-based polymer and further more particularly to a method for producing an acrylamide of high quality by hydrating an acrylonitrile using a microbial cell containing a nitrile hydratase and the like; and to a method for producing an acrylamide-based polymer of high quality from the acrylamide.BACKGROUND ART[0003]As men...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08F22/38C12P13/02
CPCC07C231/06C08F220/56C12P13/02C07C233/09C08F20/56C12N9/14C12P13/00
Inventor SHIBAMOTO, HIROKOAIKAWA, TOSHIKAZUARII, TERUOMURAMOTO, MASANORIFUKUDA, TAKESHIITO, KIYOSHIABE, TAKEYAHAZAMA, SOUICHI
Owner MITSUI CHEM INC
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