Magnetic composite material and application thereof in regeneration and repair of bone tissues

A magnetic composite material, bone tissue regeneration technology, applied in tissue regeneration, medical science, prosthesis, etc., to achieve significant promotion effect, excellent biocompatibility, and promotion of adhesion

Active Publication Date: 2011-05-11
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Although there are many materials for the treatment of bone injuries and bone defects in the prior art, there is still a need for materials that can further improve the therapeutic effect of bone injuries and bone defects

Method used

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  • Magnetic composite material and application thereof in regeneration and repair of bone tissues
  • Magnetic composite material and application thereof in regeneration and repair of bone tissues
  • Magnetic composite material and application thereof in regeneration and repair of bone tissues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] γ-Fe 2 o 3 Preparation of nanoparticles

[0061] Prepare 500mL FeCl under nitrogen 3 (0.1M) and FeSO 4 (0.06M) aqueous solution, at room temperature, 200mL ammonia water (1.5M) was added dropwise to the aqueous solution and stirred vigorously. Thirty minutes later, the resulting Fe was collected using a magnetic field 3 o 4 nanoparticles and washed three times with water. Redisperse these particles in water, and oxidize them into γ-Fe in the air at 95°C under ventilated conditions 2 o 3 . γ-Fe 2 o 3 Mix and stir with DMSA (dimercaptosuccinic acid) in an aqueous solution of pH=2.7 for 1 hour to obtain superparamagnetic γ-Fe with DMSA attached to the surface 2 o 3 Nanoparticles.

[0062] γ-Fe with DMSA attached to the surface 2 o 3 Nanoparticles (γ-Fe 2 o 3 / DMSA) particle size and morphology with transmission electron microscope observation and determination (TEM, JEOL, JEM-200EX), the results show that the particles are quasi-spherical, with an average ...

Embodiment 2

[0064] A, in 25ml small beaker, add 20ml dimethylacetamide (DMAc), the gamma-Fe of 0.5g drying prepared in embodiment 1 2 o3 Nanoparticles are dispersed in dimethylacetamide and dispersed uniformly by ultrasonic waves to obtain γ-Fe 2 o 3 a solution of nanoparticles;

[0065] B. In the above γ-Fe 2 o 3 Add 2g of dry nHA powder to the solution of nanoparticles, disperse evenly by ultrasonic wave, and obtain the solution containing γ-Fe 2 o 3 A solution of nanoparticles and nHA;

[0066] C. Containing γ-Fe in the above 2 o 3 Add 4 g of polylactic acid (PDLLA) to the solution of nanoparticles and nHA, and stir it with a stainless steel anchor stirrer controlled by a rotating motor (50 rpm) to form a fluid, well-mixed γ-Fe 2 o 3 / nHA / PDLLA / DMAc composite solution.

[0067] D. Add 2ml of the above composite material into the syringe pump, the nozzle is a 9# syringe needle, the nozzle is connected to the positive electrode of the high-voltage electrostatic generator, the r...

Embodiment 3

[0069] A, in 25ml small beaker, add 20ml dimethylacetamide (DMAc), the gamma-Fe of 0.5g drying prepared in embodiment 1 2 o 3 Nanoparticles are dispersed in dimethylacetamide and dispersed uniformly by ultrasonic waves to obtain γ-Fe 2 o 3 a solution of nanoparticles;

[0070] B. In the above γ-Fe 2 o 3 Add 2g of dry nHA powder to the solution of nanoparticles, disperse evenly by ultrasonic wave, and obtain the solution containing γ-Fe 2 o 3 A solution of nanoparticles and nHA;

[0071] C. Containing γ-Fe in the above 2 o 3 Add 2 g of polylactic acid (PDLLA) to the solution of nanoparticles and nHA, and stir it with a stainless steel anchor stirrer controlled by a rotating motor (50 rpm) to form γ-Fe with good fluidity and uniform mixing. 2 o 3 / nHA / PDLLA / DMAc composite solution.

[0072] D. Add 2ml of the above composite material into the syringe pump, the nozzle is a 9# syringe needle, the nozzle is connected to the positive electrode of the high-voltage electrost...

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Abstract

The invention discloses a magnetic composite material and an application thereof in regeneration and repair of bone tissues, as well as a method for preparing the magnetic composite material and a product prepared by the magnetic composite material, wherein the magnetic composite material comprises the following components: a) 10-50g of polymer material calculated by 100ml of organic solvent, wherein the polymer material is selected from polylactic acid, polyglycolic acid, lactic acid-glycolic acid copolymer, polycaprolactone, polyamide or poly-hydroxybutyric acid; b) 10g of hydroxyapatite nano-particles calculated by 100ml of the organic solvent; and c) 2.5g of gamma-Fe2O3 nano-particles calculated by 100ml of organic solvent, wherein the organic solvent is selected from tetrahydrofuran (THF), dimethylformamide (DMF), dimethylacetamide (DMAc), chloroform or dioxane.

Description

technical field [0001] The invention relates to a magnetic composite material for regeneration and repair of bone tissue and a preparation method thereof. The invention also relates to a product prepared from the magnetic composite material and its application. Background technique [0002] Bone injury and bone defect are common clinical diseases, often requiring bone grafting [1]. Traditional medicine usually relies on autologous bone [2] and allogeneic bone [3-4] transplantation for bone repair for bone defects caused by injury or disease. Autologous bone grafting has a good repair effect, but it has the disadvantages of limited supply and the need for a second operation, and postoperative complications can reach 8%. Allograft bone has disadvantages such as immunogenicity and pathogenicity, so it is not an ideal bone repair material. [0003] Bone tissue engineering, which emerged in the 1980s, has changed the traditional treatment model of repairing trauma at the expen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/44A61L27/50
CPCA61L27/446A61L2430/02
Inventor 许海燕孔桦齐晓谨孟洁顾宁张宇
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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