688results about How to "Reduced structure" patented technology

The invention provides immunoglobulin polypeptides comprising variant amino acids in CDRs of antibody variable domains. In one embodiment, the polypeptide is a variable domain of a monobody and has a variant CDRH3 region. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

An apparatus for treating a hollow anatomical structure comprises an implant comprising a plurality of bioabsorbable fibers. The implant has a compressed state in which the implant can fit within a cylindrical tube having an inside diameter of 8 French or less. The implant is expandable from the compressed state to an expanded state in which the implant has sufficient size to span the inside diameter of a cylindrical tube having an inside diameter of 12 French or greater.

Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

A system and associated methods to determine an optimal radiation beam arrangement are provided. The system includes a computer planning apparatus which includes a treatment plan optimization computer having a memory and an input device in communication with the treatment plan optimization computer to provide user access to control functions of plan optimization software. An image gathering device is in communication with the treatment plan optimization computer through a communications network to provide an image slice of the tumor target volume and the non-target structure volume. The plan optimization software computationally obtains and then optimizes a proposed radiation beam arrangement iteratively based on constraints to form an optimized radiation beam arrangement. A conformal radiation therapy delivery device in communication with the treatment plan optimization computer through the communications network then applies the optimized radiation beam arrangement to the patient.

The invention relates to a needle insertion device comprising a housing with a mounting surface adapted for application to the skin of a subject, where the mounting surface defines a general plane and has a needle aperture formed therein. Adhesive means is arranged on the mounting surface for adhering the insertion device to the skin of the subject, the adhesive means surrounding the needle aperture. A needle comprises a distal pointed end adapted to penetrate the skin of the subject, the pointed end being arranged within the housing in respect of the general plane. The mounting surface surrounding the needle aperture is moveable between a first position in which the pointed end of the needle is arranged within the housing, and a second position in which the pointed end of the needle projects through the needle aperture, thereby pulling the skin portion corresponding to the intended site of needle insertion against the needle.

The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries. In several aspects of the present invention, there are methods based on methylation-dependent enrichment or depletion of genomic DNA isolated from cellular and cell-free sources. In additional embodiments, there are methods and compositions for single-step high throughput preparations of Methylome libraries.

Rectangular PV modules (6) are mounted on a building roof (4) by mounting stands that are distributed in rows and columns. Each stand comprises a base plate (10) that rests on the building roof (4) and first and second brackets (12, 14) of different height attached to opposite ends of the base plate (10). Each bracket (12, 14) has dual members for supporting two different PV modules (6), and each PV module (6) has a mounting pin (84) adjacent to each of its four corners. Each module (6) is supported by attachment of two of its mounting pins (84) to different first brackets (12), whereby the modules (6) and their supporting stands are able to resist uplift forces resulting from high velocity winds without the base plates (10) being physically attached to the supporting roof structure (4). Preferably the second brackets (14) have a telescoping construction that permits their effective height to vary from less than to substantially the same as that of the first brackets (12).

The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.

The growth of continuous MOF membranes on porous polymeric supports is reported, wherein a dip-coating procedure is used to deposit a layer of seed MOF nanocrystals on the surfaces of porous polymers, preferably in the form of hollow fibers, and polycrystalline MOF membranes are subsequently grown at temperatures as low as 65° C. from precursor solutions. The present work opens the road to inexpensive and scalable fabrication of MOF membranes for large-scale separation applications.

An apparatus for treating a hollow anatomical structure comprises an implant sized for insertion into a hollow anatomical structure. The implant comprises a plurality of loose, bulked fibers. The fibers are formed from one or more bioabsorbable materials.

A driving apparatus for a DC brushless motor of a ceiling fan is provided. By setting at least one coder and one sensor outside the DC brushless motor, the driving apparatus can sense the position of magnetic poles of the motor for driving the motor. Meanwhile, a controller set with the motor stores the rotation speed of the motor before being turned off by detecting the turn-off time of a turn-on / off signal.

Prosthesis is provided for repairing or resisting the formation of bodily hernia in particular, for inguinal hernia repair or femoral hernia repair. The prosthesis comprises an inner surface and an outer surface, the inner surface forms at least one channel that is sized to receive an anatomical structure and allow it to pass through the prosthesis without substantial compression of the anatomical structure.

Apparatus and methods for treating a hollow anatomical structure comprises an implant sized for insertion into a hollow anatomical structure. The implant comprises a plurality of loose, bulked fibers. The fibers are formed from one or more bioabsorbable materials. Upon implantation, the apparatus causes a partial occlusion of the hollow anatomical structure, followed by a complete or substantially complete occlusion.

Layers of colored polymers are applied to a surface of a card and are hardened and adhered to a card via light such as ultraviolet or light having a wavelength in the blue spectrum. The layers may be applied to form three dimensional indicia on the surface of the card. For example, letters, numbers, logos, and other indicia (e.g., pictures) may be printed three dimensionally onto the surface of the card. Troughs may be formed via such layering such that indicia is provided as indentations into the added layers. Extensions may be formed via such layering such that indicia is provided as extensions from the added layers. Indicia may be provided via extensions and / or indentations. As such, embossed and / or engraved indicia may be provided on the surface of a card without impacting the structural integrity of the card.

Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

A magnetic resonance antenna has longitudinal antenna rods in a birdcage structure, and antenna ferrules connecting the longitudinal antenna rods at their ends in terms of radio-frequency. The magnetic resonance antenna has a number of radio-frequency switching elements that interrupt, in terms of radio-frequency, at least one part of the longitudinal antenna rod to detune the eigen-resonance frequency of the antenna with respect to an operating magnetic resonance frequency. For this purpose, the magnetic resonance antenna is provided with two switching lines, directed to the radio-frequency switching elements from outside of the birdcage structure, the switching lines having a ring line connected thereto running annularly on or in the birdcage structure and transverse to the longitudinal antenna rods.

Core drill bits with long crown heights are described herein. The core drill bits have a series of slots or openings that are not located at the tip of the crown and are therefore enclosed in the body of the crown. The slots may be staggered and / or stepped throughout the crown. As the cutting portion of the drill bit erodes through normal use, the fluid / debris notches at the tip of the bit are eliminated. As the erosion progresses, the slots become exposed and then they function as fluid / debris ways. This configuration allows the crown height to be extended and lengthened without substantially reducing the structural integrity of the drill bit.

A method of treating a vein comprises accessing a vein at an access point spaced from a sapheno-femoral junction. A bioabsorbable fibrous body is implanted into the vein through the access point. The body is moved in the vein toward the sapheno-femoral junction.

A method and apparatus for providing metal or non-metal vessels, including straight and curved pipes and various pipe connections, such as T's, elbows, swages, etc., and pressure containing vessels such as tanks, with an external composite lining of a webbing of biaxial or triaxial weave preferably composed of fiberglass which is pre-impregnated with a high temperature heat curable polymer composition capable of being heat cured at a temperature range of from about 275° F. to about 375° F. The vessel is prepared for bonding by abrasive cleaning and by solvent cleaning. Metal imperfections are then filled with an epoxy. A small amount a quick setting epoxy is employed to attach one end of the web to the external surface of the vessel in oriented position for wrapping of the web in intimate surface-to-surface contact with the vessel. During wrapping only enough tension is applied to the pre-impregnated webbing to eliminate any wrinkles. The number of layers of the impregnated webbing will be determined by the safe pressure containing capability of the pipe or vessel and its composite lining. An external heating element is then placed about the wrapping of pre-impregnated webbing material so as to be in substantially intimate relation therewith and is energized to apply sufficient heat for a sufficient period of time to completely cure the epoxy surface filler and to cure the polymer resin components of the pre-impregnated woven wrappings of webbing.

A method of treating a hollow anatomical structure of a patient comprises implanting a bioabsorbable fibrous body in a hollow anatomical structure. The body is secured in the hollow anatomical structure to limit migration of the body within the hollow anatomical structure.

Method of identifying a cognate nucleotide (i.e., the “next correct nucleotide”) for a primed template nucleic acid molecule. In some embodiments, an ordered or random array of primed target nucleic acids characterized by different cognate nucleotides can be evaluated using a single imaging step to identify different cognate nucleotides for a collection of different primed template nucleic acid molecules. An optional incorporation step can follow the identifying step. A polymerase different from the ones used in the binding and examination steps can be used to incorporate a nucleotide, such as a reversible terminator nucleotide, preliminary to identification of the next cognate nucleotide.

The present invention generally relates to a system for cleaning substrates. More particularly, the present invention relates to process(es) for effecting chemical removal of residues from semiconductor substrates, including silicon wafers, using a system of reactive reverse micelle(s) or microemulsions in a densified carbon dioxide matrix. Various reactive chemical agents in the reactive micelle system may be used to effect cleaning and removal of etch and metal residues to levels sufficient for commercial wafer production and processing.

The invention comprises self-lubricating polymer compositions that are especially useful in medical devices and valves and gaskets of medical devices. In a preferred embodiment, the polymer compositions comprise a thermosetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluoropolyether fluid or hydrocarbon-based synthetic oil. In other preferred embodiments, the polymer compositions contain only biocompatible components. The improved anti-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and withdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.

A system and associated methods to determine an optimal radiation beam arrangement are provided. The system includes a computer planning apparatus which includes a treatment plan optimization computer having a memory and an input device in communication with the treatment plan optimization computer to provide user access to control functions of plan optimization software. An image gathering device is in communication with the treatment plan optimization computer through a communications network to provide an image slice of the tumor target volume and the non-target structure volume. The plan optimization software computationally obtains and then optimizes a proposed radiation beam arrangement iteratively based on constraints to form an optimized radiation beam arrangement. A conformal radiation therapy delivery device in communication with the treatment plan optimization computer through the communications network then applies the optimized radiation beam arrangement to the patient.

A puncture sealant supplying / removing apparatus includes a pressure-resistant bottle, an apparatus body on which the pressure-resistant bottle can be mounted, supply hose means which supplies or returns a puncture sealant accommodated in the pressure-resistant bottle to or from a tire, and a high pressure air source.The apparatus body comprises a venturi flow-path having a venturi portion, a first flow-path extending from the venturi portion into the pressure-resistant bottle, and a second flow-path extending from an inside of the pressure-resistant bottle and connected to one end of the supply hose means. The venturi flow-path is provided at its one end with an air intake which is connected to the high pressure air source, the venturi flow-path is provided at its other end with an opening / closing tool capable of opening and closing the other end.

In one embodiment, a method for forming a circuit comprises generating bonding data specifying locations for one or more electrically conductive bonding lines and generating one or more printing instructions based on the bonding data. The method further comprises, using the printing instructions, printing the one or more electrically conductive bonding lines substantially on a surface of a substrate, the one or more electrically conductive bonding lines operable to provide electrical conductivity between a first element of the circuit and one or more second elements of the circuit.

A puncture sealant supplying / removing apparatus includes a pressure-resistant bottle, an apparatus body on which the pressure-resistant bottle can be mounted, supply hose means which supplies or returns a puncture sealant accommodated in the pressure-resistant bottle to or from a tire, and a high pressure air source. The apparatus body comprises a venturi flow-path having a venturi portion, a first flow-path extending from the venturi portion into the pressure-resistant bottle, and a second flow-path extending from an inside of the pressure-resistant bottle and connected to one end of the supply hose means. The venturi flow-path is provided at its one end with an air intake which is connected to the high pressure air source, the venturi flow-path is provided at its other end with an opening / closing tool capable of opening and closing the other end.

According to the disclosed method, there is provided a structure consisting of a silicon substrate coated with a bottom thin SiO2 layer, a doped polysilicon layer, a refractory metal layer and a top Si3N4 capping layer. Said refractory metal and doped polysilicon layers will form a polycide layer under subsequent thermal treatments. First, a sacrificial layer of a dielectric material such as oxynitride is deposited onto the structure. Oxynitride is impervious to UV radiation and has excellent conformal properties. Then, a layer of a photoresist material is deposited onto the structure and patterned to form a mask. Now the dielectric and top Si3N4 layers are anisotropically etched using the photoresist mask. The mask is stripped and the refractory metal and doped polysilicon layers are anisotropically dry etched down to the SiO2 layer using the patterned dielectric layer as an in-situ hard mask. A conformal layer of Si3N4 is deposited onto the structure, then anisotropically dry etched until the thin SiO2 layer is exposed to form the Si3N4 spacers. Diffusion regions are formed in the substrate by ion implantation. A layer of BPSG is deposited onto the structure and planarized. Contact holes are formed to expose said diffusion regions and filled with a metal to create borderless metal contacts therewith.