Modified producing method for trichlorosaccharose

Abstract

An improved production method of sucralose is characterized by comprising the steps: (1) methoxy on benzene ring is used for replacing the three ortho-hydroxide radical of 6, 1' and 6' in trityl chloride etherified sucrose molecules and acylation reaction is carried out to prepare 6, 1', 6'-trimethoxy benzyl-penta acetic sucrose through etherealization and fine purification; (2) etherealization and acyl removal reactions are carried out to the 6, 1', 6'-trimethoxy benzyl-penta acetic sucrose in water-bearing weak acid at the same time, product 6-PAS generated from the reaction is refined and enters into the next chlorination reaction step; (3) 4, 1', 6'- trichloro-4, 1', 6'-trideoxidation galacto-sucrose (namely the sucralose) is prepared through the chlorination and acyl reaction of the 6-PAS. The invention combines the advantages of a full protective line and a single protective line, spurns the defects of the existing production methods and changes the original 'five steps' of the full protective line into 'four steps', thereby promoting the recovery rate of the full protective line greatly with less reaction steps and consumption, thus resulting in a more economic and environment protective production technology compared with the traditional production technologies of the full protective line or the single protective line.

Description

technical field [0001] The invention relates to a production method of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose. Background technique [0002] 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (i.e. sucralose, Sucralose) is a new type of strong sweetener, its characteristics are: high sweetness , which is 600 times sweeter than sucrose; pure sweetness, the taste is basically the same as sucrose; stable performance, not easily damaged by acid, alkali, high temperature and other harsh environments; wide application, can be used in almost all foods; as a sweetener in food It is safe to use in middle school; low in calories, non-rodent, suitable for diabetics and dental patients. [0003] There are 8 hydroxyl groups in the molecular structure of sucrose, selectively replacing the 4, 1', 6' hydroxyl groups in the sucrose molecule with chlorine atoms is the basic principle of making sucralose. If all other hydroxyl groups in the sucrose molecule except the 4, 1' and 6 hyd...

AI Technical Summary

Problems solved by technology

The reaction density is low, it needs to consume a lot of solvents with high boiling point, easy to decompose and difficult to recover, discharges a lot of three wastes, the reaction conditions are not easy to control, and the disadvantages such as unstable yield and quality also affect its advantages.

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