Method for separating vanillin and isovanillin by three-zone asynchronous switching simulated moving bed

A technology for simulating moving bed and isovanillin, which is applied in the field of separation of vanillin and isovanillin in a three-zone asynchronously switched simulated moving bed, can solve the problems of low efficiency and achieve low solvent consumption, high yield and stable quality Effect

Inactive Publication Date: 2019-05-21
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of these by-products have similar physical and chemical properties to vanillin,

Method used

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  • Method for separating vanillin and isovanillin by three-zone asynchronous switching simulated moving bed
  • Method for separating vanillin and isovanillin by three-zone asynchronous switching simulated moving bed
  • Method for separating vanillin and isovanillin by three-zone asynchronous switching simulated moving bed

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Embodiment 1

[0031] a. Operating conditions

[0032] Mobile phase: ethanol: water solution with a volume ratio of 35:65;

[0033] Injection concentration: the injection concentration of vanillin and isovanillin is 0.5g / L;

[0034] Eluent flow rate: U d= 2mL / min;

[0035] Extraction flow rate: U e =0.962mL / min;

[0036] Injection liquid flow rate: U f =0.471mL / min;

[0037] Raffinate flow rate: U r =1.509mL / min;

[0038] Switching time: T s = 18.0 min.

[0039] b. Separation step

[0040] Fully dissolve isovanillin and vanillin in the prepared mobile phase with a concentration of 0.5g / L. The sample solution and eluent are sequentially injected into the asynchronously switched simulated moving bed chromatography system from the injection port and the eluent inlet. Asynchronously switch the controller of the simulated moving bed chromatography system. After 9.28 minutes, the injection port advances one chromatographic column along the direction of the mobile phase. After 13.7 minut...

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Abstract

The invention discloses a method for separating vanillin and isovanillin by a three-zone asynchronous switching simulated moving bed, and relates to vanillin and isovanillin. The method comprises thesteps of preparing an eluent; preparing a vanillin and isovanillin sample solution; separating the obtained vanillin from the isovanillin sample solution by adopting an asynchronous switching simulated moving bed chromatography system to obtain the vanillin and the isovanillin. According to the invention, the asynchronous switching simulated moving bed chromatography system is adopted, so that vanillin and isovanillin are successfully separated. The purpose of continuous and large-scale preparation and resolution is achieved. Under the condition that equipment investment and solvent consumption are not increased, the feeding flow is increased. Vanillin and isovanillin with the recovery rate and purity higher than 99.0% are obtained. The method has the advantages of high yield, low solventconsumption, automatic continuous production and the like. A product with stable quality can be prepared, and the method is a separation technology with a good commercial application prospect.

Description

technical field [0001] The invention relates to vanillin and isovanillin, in particular to a method for separating vanillin and isovanillin in a three-zone asynchronous switching simulated moving bed. Background technique [0002] Vanillin, the chemical name is 3-methoxy-4-hydroxybenzaldehyde, the molecular formula is C 8 h 8 o 3 , the molecular weight is 152.15g / mol, it is white to light yellow crystal under normal conditions, the melting point is 81°C, and the molecular structure formula is: [0003] [0004] Vanillin is currently the synthetic flavor with the largest supply and demand in the world. It is widely used in food additives, chemicals, flavoring agents or fixatives in the tobacco industry, and can also be used as a starting material for the synthesis of some important fine chemicals. At the same time Also because of its antioxidant and antibacterial properties, it can also be used as a food preservative ([1] Yang Wenwen, Wu Qiulin, Tang Hongzhi, etc. "Quee...

Claims

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Application Information

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IPC IPC(8): G16C20/00
Inventor 姚传义吕荣森陈翠雪卢英华
Owner XIAMEN UNIV
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