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156results about "Chemoinformatics" patented technology

Systems and methods for visualizing structural variation and phasing information

A system for providing structural variation or phasing information is provided. The system accesses a nucleic acid sequence dataset corresponding to a target nucleic acid in a sample. The dataset comprises a header, synopsis, and data section. The data section comprises a plurality of sequencing reads. Each sequencing read comprises a first portion corresponding to a subset of the target nucleic acid and a second portion that encodes an identifier for the sequencing read from a plurality of identifiers. One or more programs in the memory of the system use a microprocessor of the system to provide a haplotype visualization tool that receives a request for structural variation or phasing information from the dataset. The request is evaluated against the synopsis thereby identifying portions of the data section. Structural variation or phasing information is formatted for display in the haplotype visualization tool using the identified portions of the data section.
Owner:10X GENOMICS

Load-controlled device for a patterned skin incision

A skin incision device has a casing having a bottom surface with a slot formed therein, a cover positioned on the casing and slidable in a direction toward the bottom surface, a blade positioned in the casing adjacent the slot, an actuator cooperatively positioned between the cover and an interior of the casing, and a carriage element. The actuator engages the blade by its horizontal displacement triggered by the slidable movement of the cover toward the bottom surface of the casing. The carriage element guides the movement of the blade between a pre-actuated position and a post-actuated position. The blade moves outwardly through the slot, cuts with a horizontal movement, and returns inwardly through the slot.
Owner:HELENA LAB

Chemical Compositon And Its Devlivery For Lowering The Risks Of Alzheimer's Cardiovascular And Type -2 Diabetes Diseases

Chemical compositions of bioactive compounds and / or bioactive molecules for lowering the risks of Alzheimer's, Cardiovascular and Diabetes diseases are described. Targeted, passive and programmable / active deliveries of the bioactive compounds and / or bioactive molecules are described. Many embodiments of various subsystems for detection of disease specific biomarkers / an array of disease specific biomarkers and programmable / active delivery of the bioactive compounds and / or bioactive molecules in near real-time / real-time are also described. A portable internet appliance, a portable internet cloud appliance and an augmented reality personal assistant subsystem are also described along with various applications.
Owner:MAZED MOHAMMAD A +1

Structured support of clinical heatlhcare professionals

A system and method is provided for using a communications network coupling a plurality of computer systems, a database, and a at least one external data source together to facilitate communication therebetween. The plurality of computer systems is configured to extract at least one term from a medical order for the patient, identify at least one medical concept related to an extracted term, and identify at least one medical data element related to an identified medical concept. The plurality of computer system is further configured to query the database for the identified at least one medical data element, query the at least one external data source to retrieve at least one guideline for performing at least one intervention associated with the at least one medical data element, and generate a user interface that displays at least a portion of a result from the queries.
Owner:MASSACHUSETTS GENERAL PHYSICIANS ORG INC

Method of creating particle size distribution model, method of predicting degradation of fuel cell catalyst using the method of creating particle size distribution model, and method of controlling fuel cell using the method of predicting degradation of fuel cell catalyst

A particle size distribution creating method includes a particle size range determining step, an integrating step of integrating the frequency of appearance of particles within the particle size range determined in the particle size range determining step, a division point determining step of determining particle sizes that provide division points, using the integral of the frequency of appearance obtained in the integrating step, and a typical point determining step of determining the minimum particle size, maximum particle size and the particle sizes of the division points as typical points. This method is characterized by assuming a particle size distribution which contains particles having the particle sizes of the respective typical points and is plotted such that the frequency of appearance of the particles having the particle size of each of the typical points is equal to the integral over each of the regions defined by the typical points, and obtaining the assumed particle size distribution as a particle size distribution model.
Owner:TOYOTA JIDOSHA KK

Mobile device based vehicle diagnostic system

A vehicular diagnostic communications system, and components thereof, are provided for an apparatus and technique for communicating vehicular diagnostic information over a cellphone network. The system includes a code reader having a vehicle diagnostic port connector for receiving vehicle diagnostic information from the vehicle diagnostic port. The code reader also has a local connectivity network circuit for communicating vehicle diagnostic information between the vehicle diagnostic port connector and a local connectivity circuit. A cellphone is arranged in communication with the local connectivity network for communicating vehicle diagnostic information between the code reader and a cellular telephone network.
Owner:INNOVA ELECTRONICS

System and method for targeting relevant research activity in response to diagnostic marker analyses

A system and method for targeting relevant research activity for clinical application in response to diagnostic markers analyses is described. Diagnostic analysis is performed to detect the level of each of at least three diagnostic markers. The levels of the tested markers are used to identify relevant publications from among a large database of articles. The most relevant literature, such as, one which reports research and studies that have been conducted to identify, moderate, and define the mechanisms unique to individual and combinations of diagnostic markers for various disease states, is then provided to the patient and / or the patient's physician, optionally with a summarization of the treatment recommendations from the provided literature. The customized information delivery provides a range of published peer-reviewed therapeutic options and / or published research studies.
Owner:LAMBERT REBECCA

Pneumatic tube carrier routing and tracking system

A system and method provides for a pneumatic tube carrier routing and tracking system having a system control module that captures and presents tracking information associated with sending and receiving carriers. The pneumatic tube carrier tracking system comprises sending and receiving stations connected by pneumatic tubing, and which are configured to securely send carriers, with receiving users optionally being restricted from unauthorized access of carriers. The receiving station further comprises a plurality of receiving bins, each comprising a door for preventing access to the receiving bin by unauthorized users. The sending and receiving stations have identifying tag readers configured to scan identifier tags to read carrier delivery, carrier receipt and receiving user information. Destination and intended recipient information are entered at the sending station when sending a carrier and are transmitted to a system control module, which routably delivers and secures the carriers in response the destination and intended recipient information.
Owner:PEVCO SYST INT

Comprehensive evaluation method of underground water

InactiveCN106845112AReflect drinking water safetyChemoinformaticsTesting waterHuman bodyHealth risk
The invention relates to a comprehensive evaluation method of underground water, wherein the method includes steps of a, re-classifying the classification dividing value of seventeen water quality indexes such as manganese, fluoride, monoiodide and mercury in the underground water quality; b, selecting the water quality index participated in rating according to the testing index of the underground water sample, and substituting the testing result of the underground water sample and the classification dividing value of the selected water quality index participated in the evaluation to a membership function, and calculating and acquiring a fuzzy membership matrix; c, performing data conversion on a toxic index of the water quality index; d, according to the converted toxic index, the sample testing result, and the classification dividing value of the water quality index, calculating a weight matrix; e, coupling the fuzzy membership matrix with the weight matrix, and acquiring the evaluation result matrix and the evaluation grade of the underground water quality. The evaluation result fully considers about the risk of the human body health, and can comprehensively evaluate the underground water quality from the view of the human body health risk; the evaluation result can further objectively reflect the drinking safety.
Owner:INST OF HYDROGEOLOGY & ENVIRONMENTAL GEOLOGY CHINESE ACAD OF GEOLOGICAL SCI

Method for Acquiring Nuclide Activity with High Nuclide Identification Ability Applicable to Spectroscopy Measured from Sodium Iodide Detector

A method for acquiring a nuclide activity with high nuclide identification ability applicable to a spectroscopy measured from sodium iodide detector is described. In performing this, an electronic impulse signal received by the sodium iodide detector is transformed into a spectroscopy. Then, the resulting spectroscopy is analyzed in characteristics with some previous calculations. The analysis result provides an assistance in establishing a system capable of identifying a nuclide and calculating the activity of the nuclide, which not only features an excellent nuclide identification ability but also presents a fantabulous reconstruction result. Thereby the present invention may be used for establishing a system capable of qualitative nuclide identification and activity determination that can be adapted in applications of waste clearance management.
Owner:INST NUCLEAR ENERGY RES ROCAEC

Gene signature biomarkers of tumor response to pd-1 antagonists

The present disclosure describes gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
Owner:MERCK SHARP & DOHME CORP

Multi-scale continuous calculation method for solving mesomechanics performance of energetic material

The invention discloses a multi-scale continuous calculation method for solving the mesomechanics performance of an energetic material. The method comprises the following steps: respectively carryingout molecular dynamics simulation and coarse graining molecular dynamics simulation on an explosive crystal component and a polymer binder component in PBX; converting a real PBX structure into a random round particle digital model through an effective approximation method; connecting key parameters from microcosmic scale to mesoscopic scale; calculating the mechanical properties of particles PBXunder a mesoscopic scale, establishing a representative volume meta-model of PBX on the mesoscopic scale by adopting a material point method, researching the mechanical behaviors of PBX under uniaxialcompression to obtain the elasticity modulus and state equation parameters of PBX, and inputting the elasticity modulus and state equation parameters into a continuum of a macroscopic scale as parameters for calculation. According to the invention, a composite energetic material cross-scale continuous calculation method completely based on theoretical calculation is realized from microcosmic scale to microcosmic scale and from single component to compound, and the method has important guiding significance for safety design of explosives.
Owner:CHONGQING UNIV OF POSTS & TELECOMM

Hydrocarbon fuel mechanism simplification method

The invention discloses a hydrocarbon fuel mechanism simplification method which comprises a step S1 of adopting a direct relation graph method based on error propagation to perform mechanism simplification from the angle of component coupling; a step S2 of adopting a main component analysis method to perform mechanism simplification from the angle of elementary reaction; a step S3 of adopting a linear isomer lumping method to perform mechanism simplification from the angle of component isomers; a step S4 of adopting a sensibility analysis method to correct kinetic parameter values; and performing mechanism simplification from angle of perturbation factors. According to the hydrocarbon fuel mechanism simplification method, on the premise of maintaining small scale dimension of the mechanism, a mechanism computational accuracy effect is ensured, and computer automatic mechanism simplification thought is implemented basically.
Owner:WUHAN UNIV OF SCI & TECH

Response surface method for optimizing extraction process of red-fleshed pitaya peel anthocyanin

The invention provides a response surface method for optimizing extraction process of red-fleshed pitaya peel anthocyanin. The peel of red-fleshed pitaya is taken as a raw material, a single-factor experimental method is utilized for exploring the effects of ethanol concentration, extraction time, extract liquid pH value and extraction temperature on the red-fleshed pitaya peel anthocyanin, the ethanol concentration, extract liquid pH value, extraction temperature and extraction time are taken as influence factors, the extracting solution absorbance of the red-fleshed pitaya peel anthocyanin is taken as a response value, a central combined experiment is utilized for mathematical modeling, the optimal ethanol concentration, extract liquid pH value, extraction temperature and extraction time of the red-fleshed pitaya peel anthocyanin are determined through the analysis of a response surface, and the extraction volume of the obtained anthocyanin is 58.9 mg / g. According to the response surface method, the benefits can be improved, the pollution of the peel to the environment can be reduced, and the value of pitaya is improved.
Owner:PUTIAN UNIV

A molecular docking algorithm method based on quantum particle swarm optimization algorithm

The invention relates to the technical field of computer application, in particular to a molecular docking calculation method based on a quantum particle swarm optimization algorithm, wherein, the molecular docking calculation method based on the quantum particle swarm optimization algorithm comprises the following steps: obtaining a protein PDB file; preprocessing the protein PDB file to obtain aprotein receptor file and a protein ligand file; performing lattice docking pretreatment on the protein receptor file and the protein ligand file; setting lattice docking parameters and selecting docking algorithm to run molecular docking program for molecular docking; outputting docking results. The molecular docking calculation method based on the quantum particle swarm optimization algorithm provided by the invention has the advantages of simple steps, few control parameters and easy solution.
Owner:WUXI CITY COLLEGE OF VOCATIONAL TECH

Detecting hepatocellular carcinoma

Provided herein is technology for hepatocellular carcinoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of hepatocellular carcinoma.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES +1

Parental genome assembly method

Provided is a parental genome assembly method, comprising: using the sequencing data of parental selfing line progeny population to assemble and perfect the parental genome data. Also provided is a device for implementing the method.
Owner:BGI TECH SOLUTIONS

Method for producing a three-dimensional characteristic model of a porous material sample for analysis of permeability characteristics

The present invention relates to a method for producing a three-dimensional characteristic model of a rock sample for analysis of the spatial and physical characteristics of materials subsequent to the processing of images obtained by means of computer tomography. The method includes producing a three-dimensional tomographic image of a sample of material, identifying areas where the structure of the material is homogeneous, assigning a particular material density value to each such area, assigning a particular porosity value to each pixel, assigning a particular absolute permeability value to each pixel, forming a three-dimensional characteristic model on the basis of the porosity and permeability values of each pixel, and calculating the absolute permeability of the entire sample or of a portion thereof in any direction by means of computational fluid dynamics. The technical result is an increase in the precision and reliability of data obtained regarding the permeability characteristics of a sample of porous material, without the need to employ additional financial and labor resources.
Owner:OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTIU INTROVISION RESERCH & DEV

System and method for simulating and modeling the distribution of discrete systems

A system and method are introduced for simulating the particulate physical systems governed by population balance equations with particle splitting (breakage) and aggregation based on accurately conserving an unlimited number of moments associated with the particle size distribution. The basic idea is based on the concept of primary and secondary particles, where the former is responsible for the distribution reconstruction while the latter one is responsible for different particle interactions such as splitting and aggregation. The system and method are found to track accurately any set of low-order moments with the ability to reconstruct the shape of the distribution.
Owner:ATTARAKIH MENWER ATTARAKIH

Thick-layer spreading cold mixing large gap emulsified asphalt mixture and design method thereof

The invention discloses a thick-layer spreading cold mixing large gap emulsified asphalt mixture and a design method thereof, and belongs to the technical field of a modern pavement. Based on a mineral aggregate main aggregate void volume filling method, use amount of mineral powders, thick and fine aggregates and mineral powders is calculated, optimal liquid use amount is preliminarily determined through wrapping and covering tests and mixing tests, and optimal asphalt amount, optimal emulsified asphalt, and optimal adding water mixing amount are finally determined through a Marshall test. The target void content of the emulsified asphalt mixture is 7%-30%. Through the design method, the emulsified asphalt mixture used for a matrix layer of a semi-flexible pavement, and each layer of a drainage pavement and a porous pavement can be manufactured. The cold mixing emulsified asphalt mixture and a large gap pavement are combined, and a paving effect of a hot mixing asphalt pavement can be achieved. The emulsified asphalt mixture is energy saving and environmentally friendly, and aging degree of the emulsified asphalt mixture in a construction is reduced.
Owner:GUANGZHOU UNIVERSITY

Accelerating the discovery of effective photonic reagents

A method for accelerating searches for optimal control of photonic reagents is provided. Closed loop feedback is applied to control a quantum system. A direct search deterministic technique is used for refining said closed loop feedback control. A quantum system controller is also provided.
Owner:THE TRUSTEES FOR PRINCETON UNIV

Water quality criterion derivation method for human health protection and safety evaluation method of water quality of drinking water source region

ActiveCN107092811AThe derivation process is simpleThe deviation of the derivation result is smallChemoinformaticsTesting waterEnvironmental resistanceWater source
The invention belongs to the technical field of water quality safety evaluation and particularly relates to a water quality criterion derivation method for human health protection and a safety evaluation method of water quality of a drinking water source region. When whether certain water quality is safe is evaluated, the carcinogenic effect acting mode of a pollutant is judged firstly, water quality criterion values for human health protection are calculated by use of corresponding derivation formulas according to the carcinogenic effect acting mode, then, the concentration value of pollution matter of the to-be-detected drinking water source region is detected, if the concentration value is lower than the water quality criterion value, the quality of drinking water is safe, and otherwise, the quality is not safe. The provided water quality criterion derivation method is simple, the derivation result error is small, the pertinence is high, and a theoretical basis is provided for the environmental protection department to set the water quality standard of drinking water for human health protection.
Owner:CHINESE RES ACAD OF ENVIRONMENTAL SCI

Physical activity amount meter

ActiveCN103402430ASurgeryInertial sensorsTarget physical activityPedometer
The pedometer is equipped with a physical activity amount-acquiring unit (11) that acquires the amount of physical activity of the person being measured, an indicator-acquiring unit (15) that acquires an indicator pertaining to the amount of physical activity, and an indicator-outputting unit (18) that outputs the acquired indicator. The indicator-acquiring unit (15) comprises a physical activity age-acquiring unit (16) for acquiring, using somatic information about the person being measured, the physical activity age, which represents the standard age of people having the same amount of physical activity as the amount of physical activity acquired in a unit period of time. An indicator for achieving a target physical activity age is acquired on the basis of the acquired physical activity amount.
Owner:OMRON HEALTHCARE CO LTD

Accelerating simulating method capable of overcoming rapid migration of surface species in heterogeneous catalysis

The invention relates to an accelerating simulating method capable of overcoming rapid migration of surface species in heterogeneous catalysis. The accelerating simulating method comprises the following steps: 1) starting to simulate and initializing a catalyst crystal mesh model; 2) dividing events in the heterogeneous catalysis process into rapid events and slow events; 3) traversing surface sites for matching events, establishing a corresponding slow event probability list for a slow event list, and adopting a roulette algorithm for selecting a present iterative event; 4) performing VSSM canonical algorithm on the slow event probability list, thereby performing system boosting simulation, including selecting events and reaction sites, boosting system time, re-matching local environmentand updating the event list; 5) redistributing quick migrating species for quick events and updating the surface configuration; 6) repeating the step 4) till achieving the maximal iteration steps or the maximal system boosting time, and then performing data post-processing and ending. Compared with the prior art, the accelerating simulating method provided by the invention has the advantages of high practicability, quickness in boosting, physical significance, and the like.
Owner:EAST CHINA UNIV OF SCI & TECH
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