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Use of bioflavanoid or polyphenolic substance for treating parkinson's disease

A technology of bioflavonoids and polyphenolic compounds, applied in the field of preventing or treating Parkinson's disease, bioflavonoids or polyphenolic compounds

Active Publication Date: 2009-05-20
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no bioflavonoids have been reported to have pharmacological activity in the treatment of Parkinson's disease

Method used

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  • Use of bioflavanoid or polyphenolic substance for treating parkinson's disease
  • Use of bioflavanoid or polyphenolic substance for treating parkinson's disease
  • Use of bioflavanoid or polyphenolic substance for treating parkinson's disease

Examples

Experimental program
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Embodiment 1

[0035] Example 1 Kaempferol-3-oxyrutinoside, dehydrated safflower yellow B, 6-hydroxykaempferol-3,6-dioxyglucoside, (2S)-4',5-dihydroxy-6,7 -Preparation of dioxyglucose dihydroflavone glycoside and rutin

[0036] 1. Reagents and medicines

[0037] Ethanol and methanol used for conventional extraction and separation are all analytical reagents, methanol for preparation is chromatographically pure reagents, produced by Beijing Chemical Factory, and acetonitrile is Fisher reagent (Fisher Scientific, Fairlawn, NJ). Deionized water is prepared from purified water through a Millipore Simplicity pure water system.

[0038] The macroporous resin (AB-B) was purchased from Nankai University, Tianjin; the gel Sephadex LH-20 (25-100 μm) for the chromatography column was a product of Amersham Biosciences, and was repackaged by Beijing Branch; the ODS reversed-phase column filler (50 μm) was Produced by Merk.

[0039] 2. Medicinal materials

[0040] Safflower is the dried petals of Cart...

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Abstract

The invention discloses application of bioflavonoids or polyphenol compounds to preventing and treating Parkinson diseases. The bioflavonoids or polyphenol compounds can be selected from kaempferol-3-O-rutinoside, dehydrated carthamin yellow B, 6-hydroxyl kaempferol-3, 6-dioxygen glucoside, (2S)-4', 5-dihydroxyl-6, 7-dioxygen flavonone glucoside, rutin, quercetin, vanillina or isovanillin. Through large amount of experiments, the bioflavonoids or polyphenol compounds have activity of interacting with protein DJ-1 related to the Parkinson diseases. Through further experiments, the bioflavonoids or polyphenol compounds have pharmaceutical activities for resisting oxidative stress, preventing apoptosis of PC12 cells or primary nerve cells induced by the oxidative stress, inhibiting active oxygen generation in cells, improving activity of tyrosine hydroxylase, and the like, and can be used for preventing or treating the Parkinson diseases.

Description

technical field [0001] The invention relates to a new application of bioflavonoids or polyphenolic compounds, in particular to the application of bioflavonoids or polyphenolic compounds in preventing or treating Parkinson's disease, and belongs to the field of medicinal chemistry. Background technique [0002] Parkinson's Disease (PD), also known as Parkinson's palsy, is a common neurodegenerative disease in middle-aged and elderly people. The main pathological change of PD is the degeneration of dopamine (DA) neurons in the substantia nigral compacta (SNc). When the neuron degeneration reaches a certain threshold, symptoms begin to appear, mainly manifested as resting tremor and bradykinesia And muscle rigidity, in addition to abnormal gait, posture, cognitive impairment and other symptoms. Its pathogenesis is related to the degeneration and loss of dopamine neurons in the nigrostriatum of the midbrain. At present, the exact pathogenesis of PD is still unclear, but there ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61K31/11A61P25/16
Inventor 蒲小平有贺宽芳曲伟果德安
Owner PEKING UNIV
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