Gold nanoflower modified ionic liquid functionalized graphene paper electrode as well as preparation method and application thereof

A gold nanoflower and ionic liquid technology, which is applied to electrochemical variables of materials, material analysis by electromagnetic means, instruments, etc., can solve the problems of low load, poor stability and low sensitivity of enzyme-free sensors, and avoid agglomeration. and disordered stacking, good workability, and low cost

Active Publication Date: 2017-06-09
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0005] In view of the above defects or improvement needs of the prior art, the present invention provides a gold nanoflower modified ionic liquid functionalized graphene paper electrode and its preparation method and application. Graphene paper electrodes are optimized and applied to electrochemical biosensors, thereby solving the technical problems of low loading, low sensitivity, and poor stability of existing nanomaterial-based enzyme-free sensors

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  • Gold nanoflower modified ionic liquid functionalized graphene paper electrode as well as preparation method and application thereof
  • Gold nanoflower modified ionic liquid functionalized graphene paper electrode as well as preparation method and application thereof
  • Gold nanoflower modified ionic liquid functionalized graphene paper electrode as well as preparation method and application thereof

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preparation example Construction

[0036] The invention provides a three-dimensional ionic liquid functionalized graphene paper electrode modified by gold nanoflowers, and its preparation method comprises the following steps:

[0037] (1) Graphene oxide, dopamine, hydrophilic organic ionic liquid and chloroauric acid are successively dissolved in water, and mixed uniformly to obtain a mixed solution; the specific operation steps are:

[0038] a. Prepare a graphene oxide dispersion solution with a concentration of 2-5 mg / mL, a precursor dopamine solution with a concentration of 2-5 mg / mL, and a chloroauric acid solution with a concentration of 1 g / mL;

[0039] b. mixing the graphene oxide dispersion with the dopamine solution, and ultrasonically treating the solution to mix it evenly;

[0040] c. Add a hydrophilic organic ionic liquid to the above mixture, and then ultrasonically treat it to promote its uniform dispersion and mixing;

[0041] d. mixing the configured chloroauric acid solution with the above-men...

Embodiment 1

[0059] Weigh 80 mg of graphene oxide and ultrasonically disperse it in 20 ml of water to prepare a 4 mg / mL graphene oxide dispersion, weigh 40 mg of dopamine and dissolve it in 20 ml of water with stirring to form a 2 mg / mL precursor dopamine solution. Mix the graphene oxide dispersion prepared above with the dopamine solution, and sonicate to make the solution mix uniformly; then add 0.2mL of 1-butyl-3 methylimidazolium tetrafluoroborate ionic liquid to the above mixture, and sonicate again, Promote its dispersion and mixing; take 0.05mL of 1g / mL chloroauric acid solution and mix it with the above solution.

[0060] The above mixed solution was taken in a glass bottle and placed in an oven at 90° C. for 6 hours (that is, the self-assembly reaction was carried out for 6 hours) to obtain a three-dimensional network graphene gel. The obtained three-dimensional network graphene gel was rinsed with water, and dried in a vacuum freeze dryer. figure 2 It is the scanning electron m...

Embodiment example 2

[0065] (1) Preparation of gold nanoflower / ionic liquid-graphene paper electrode

[0066] Weigh 120 mg of graphene oxide and ultrasonically disperse it in 20 ml of water to prepare a 6 mg / mL graphene oxide dispersion, weigh 40 mg of dopamine and dissolve it in 20 ml of water with stirring to form a 2 mg / mL precursor dopamine solution. Mix the above prepared graphene oxide dispersion and dopamine solution, and sonicate to make the solution mix uniformly; then add 0.3mL1-butyl-3 methylimidazolium tetrafluoroborate ionic liquid to the above mixture, and sonicate again, Promote its dispersion and mixing; take 0.05mL of 1g / mL chloroauric acid solution and mix it with the above solution. The above mixed solution was put in a glass bottle and placed in an oven at 90°C for 6 hours to obtain a three-dimensional network graphene gel. The obtained three-dimensional network graphene gel was rinsed with water, and vacuum freeze-dried.

[0067] (1) 30 mg of gold nanoflower-modified functio...

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Abstract

The invention discloses a gold nanoflower modified ionic liquid functionalized graphene paper electrode as well as a preparation method and application thereof in electrochemical detection of breast cancer cells. The electrocatalytic active component of the composite paper electrode is gold nanoflower; and a catalyst carrier is a three-dimensional porous graphene skeleton. In the invention, a gold nanoflower modified ionic liquid functionalized graphene composite is prepared by use of dopamine assisting one-pot self-assembly; and water is adopted for disperse suction filtration to obtain functionalized graphene paper. The process of the method is simple and easy to control, and a functionalized graphene product with controllable morphology can be obtained. Due to the unique structural properties and synergistic effect of different components in the gold nanoflower / ionic liquid-graphene composite, the functionalized graphene paper electrode has good performance when adopted to detect small-molecule metabolite active oxygen radical, hydrogen peroxide (H2O2).

Description

technical field [0001] The invention belongs to the field of electrochemical biosensors, and more specifically relates to an ionic liquid functionalized graphene paper electrode modified by gold nanoflowers and a preparation method and application thereof. Background technique [0002] Due to its high prevalence, high recurrence rate and potential lethality, cancer has become a huge problem facing the medical community all over the world. Currently available methods of clinical diagnosis of cancer are mainly based on imaging techniques using computed tomography and cytomorphological analysis or histopathology, detection of cancer by magnetic resonance imaging, X-rays, mammography, endoscopy, and ultrasonography, among others. However, these clinical medical diagnostic techniques can detect the existence of cancer only when the cancer cells proliferate in large quantities, invade the surrounding tissues, and even metastasize to the whole body. They lack the necessary sensitiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/327
CPCG01N27/327G01N27/48
Inventor 肖菲张艳肖健王露
Owner HUAZHONG UNIV OF SCI & TECH
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