Method for preparing Broussonetia papyrifera red pigment, and use thereof

A technology for constructing tree fruit and pigments, which is applied in the fields of food and beverages and medicine, and can solve the effects of liver function and transaminase index, the growth of sales is not as good, and the prevention, diagnosis, detection, protection, treatment and research of tree fruit pigments have not been found And other issues

Inactive Publication Date: 2006-11-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0072] Tetrahydroaminoacridine is the first cholinesterase inhibitor approved by the FDA and clinically used for the treatment of Alzheimer's disease, but regulations still need to be improved
[0079] The disadvantage of tacrine is that it has a great impact on liver function and transaminase index, which restricts the development of the market, and its sales growth is far behind other AD drugs
[0166] According to literature search, so far, no report has been found on the active part of the traditional Chinese medicine Mushizi, which is used for the prevention, diagnosis, detection, protection, treatment and research of anti-oxidation and related diseases.

Method used

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  • Method for preparing Broussonetia papyrifera red pigment, and use thereof
  • Method for preparing Broussonetia papyrifera red pigment, and use thereof

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preparation example Construction

[0266] 2.1. Preparation of sarcocarp pigment Fresh and mature sarcocarp fruit was picked and identified by Professor Zheng Hanchen from the Pharmacy Teaching and Research Office of the Second Military Medical University. After drying, mash it into a pulp, add acetone to soak at room temperature, pour out the soaking liquid, add acetone again to soak until the pulp of mulberry fruit is colorless. The extracts are combined, filtered and distilled to recover acetone to obtain the fruit pigment product. Prepare 10% pigment aqueous solution with distilled water, and carry out TCL analysis. The developer is n-butanol: glacial acetic acid: water (4:1:5).

[0267] 2.2. Physicochemical properties of the fruit pigment

[0268] 2.2.1. Solubility The mulberry pigment is easily soluble in water, soluble in strong polar solvents such as methanol and acetic acid, and insoluble in weak polar organic solvents such as absolute ethanol, chloroform, benzene, and ether.

[0269] 2.2.2. Heat resi...

Embodiment 1

[0281] Embodiment 1, the preparation of fruit pigment powder injection

[0282] Take 38g of sarcocarp pigment, add 20g of methylcellulose, add 5000ml of water for injection, stir to dissolve; add water for injection to 10,000ml, add 3.0g of activated carbon for needles, stir for 30 minutes; decarbonize and filter; use 0.22μm Microporous membrane filtration; filling into sterile vials, 2ml per bottle, half-stoppered; freeze-dried, then cork and cover.

Embodiment 2

[0283] Embodiment 2, the preparation of fruit pigment powder injection

[0284] (1) Prescription

[0285] Marigold Pigment for Injection 38g

[0286] Mannitol 40g

[0287] Add water for injection to 10000ml

[0288] A total of 5000 bottles were made

[0289] (2) Preparation process

[0290] According to the above prescription, take the prescribed amount of fruit pigment, add it to an appropriate amount of water for injection, stir to dissolve it; add the prescribed amount of mannitol, stir it to dissolve completely, add water for injection to the full amount; add 0.1% liquid amount of activated carbon for injection , fully stirred for 30 minutes; decarbonized and filtered; filtered with a 0.22 μm microporous membrane; filled, half-plugged; freeze-dried, plugged and capped. A total of 4867 bottles were produced, with a yield of 97.35%.

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Abstract

A papermulberry fruit pigment is a free radical removing agent with antioxidizing function and prevention of free radical generation. It can be used to prevent and delay senility, and prevent and treat the relative diseases, such as senile dementia, tumor, inflammation, cerebral ischemia, etc.

Description

technical field [0001] The invention relates to the technical fields of medicine, food and beverage, etc., in particular to a preparation method and application of a component of the traditional Chinese medicine chuzizi, and more specifically to a preparation method and application of the fruit pigment. Background technique [0002] (1) Research overview of traditional Chinese medicine Chushizi [0003] 1 Overview [0004] The traditional Chinese medicine Chushizi is the ripe fruit of Broussonetia papyrifera (L.) Vent., a common traditional Chinese medicine. However, in terms of names and applications of Chushizi and its original plants, the records in Materia Medica are not completely consistent with modern records, and some of them have actually changed with historical changes. [0005] The original name of mulberry tree, also known as Gu, is generally believed to be recorded in the "Famous Doctors" in modern literature, and it is listed as the top grade: "maintains impo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A23L33/105A61K131/00A61P39/06
Inventor 秦路平庞素秋黄宝康张巧艳张宏韩婷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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