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Application of naloxone and composition thereof in preparing drug for treating cancer

A technology of naloxone and its composition, which is applied in the application field of naloxone and its composition as the preparation of drugs for treating cancer, can solve problems such as no reports, and achieve the effect of proliferation and improvement of immune function

Inactive Publication Date: 2009-08-26
单风平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Therefore, so far, naloxone has not seen any reports on the treatment of tumors or the improvement of human immunity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prepare naloxone at a concentration of 0.1 microgram / ml, and use it from 0.1 microgram / kg body weight / day to 10 mg / kg body weight / day.

Embodiment 2

[0016] The hydrochloride salt of naloxone is formulated at a concentration of 0.1 micrograms / ml, and used at a rate of 0.1 micrograms / kg body weight / day to 10 mg / kg body weight / day.

Embodiment 3

[0018] The concentration of naloxone is 0.1 microgram / ml, and the concentration of methionine enkephalin is 0.0001 mg / ml. The two solutions are mixed and used at a rate of 0.1 microgram / kg body weight / day to 10 mg / kg body weight / day.

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PUM

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Abstract

The invention belongs to the technical field of treating tumor by adopting an immunization therapy method, and particularly relates to application of naloxone or hydrochloride thereof or composition of the naloxone or the hydrochloride thereof with methionine enkephalin in preparing a drug for treating cancer. The application of the naloxone in preparing the drug for treating the cancer is characterized in that the naloxone and the hydrochloride thereof or the composition of the naloxone and the hydrochloride thereof and the methionine enkephalin are applied to preparing the drug for treating the cancer. The drug can be prepared into tablets, capsules, spraying agent, aerosol and eye drops. The application aims to fill the blank on the research of treating the cancer by using the naloxone and the hydrochloride thereof or / and the composition of the naloxone and the hydrochloride thereof and the methionine enkephalin.

Description

Technical field: [0001] The invention belongs to the technical field of using immunotherapy to treat tumors, and in particular relates to the application of naloxone or its hydrochloride, alone or in combination with methionine enkephalin, as a medicine for treating cancer. Background technique: [0002] Naloxone, the English name is Naltrexone, also known as propylene morphine, it is a derivative of oxydihydromorphone, it or its hydrochloride, its chemical structure is similar to morphine, and it is a specific morphine receptor antagonist. The body is stereospecifically bound. It is a clinical drug that has been approved by the state at present. It has the advantages of small side effects and a wide range of safety. It is currently the most widely used opioid receptor antagonist in clinical practice. Mainly used for: 1. Rescue acute poisoning of narcotic analgesics, antagonize the respiratory depression caused by such drugs, and revive the patient. 2. Antagonize the resid...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K38/08A61P35/00
Inventor 单风平尼古拉·波罗尼可夫吕昌龙
Owner 单风平
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