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Application of combination of low-dose naltrexone and methionine-enkephalin to preparation of anti-cancer drug

A technology of methionine enkephalin and anticancer drugs, applied in the direction of drug combination, antineoplastic drugs, etc., can solve the problems of poor curative effect and safety, no breakthrough, large side effects, etc., achieve high safety, improve immune function, and reduce side effects small effect

Inactive Publication Date: 2012-11-21
单风平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a low-dose naltrexone combined with methionine enkephalin as an application in the preparation of anticancer drugs. Large, poor efficacy and safety, no breakthrough and other problems

Method used

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  • Application of combination of low-dose naltrexone and methionine-enkephalin to preparation of anti-cancer drug
  • Application of combination of low-dose naltrexone and methionine-enkephalin to preparation of anti-cancer drug
  • Application of combination of low-dose naltrexone and methionine-enkephalin to preparation of anti-cancer drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 2:

[0041] The scientific name of naltrexone is 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, molecular formula: C20H23NO4, molecular weight: 341.4, artificially synthesized hydrochloride white Powder; the molecular structure of methionine enkephalin is: Tyr-Gly-Gly-Phe-Met, which is a white powder artificially synthesized by solid-phase or liquid-phase method, with a molecular weight of 780;

Embodiment 2

[0043] Example 3:

[0044]The scientific name of naltrexone is 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, molecular formula: C20H23NO4, molecular weight: 341.4, artificially synthesized hydrochloride white Powder; the molecular structure of methionine enkephalin is: Tyr-Gly-Gly-Phe-Met, which is a white powder artificially synthesized by solid-phase or liquid-phase method, with a molecular weight of 770;

Embodiment 3

[0046] Example 4:

[0047] The scientific name of naltrexone is 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one, molecular formula: C20H23NO4, molecular weight: 341.4, artificially synthesized hydrochloride white Powder; the molecular structure of methionine enkephalin is: Tyr-Gly-Gly-Phe-Met, which is a white powder artificially synthesized by solid-phase or liquid-phase method, with a molecular weight of 760;

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Abstract

The invention relates to application of combination of low-dose naltrexone and methionine-enkephalin to preparation of an anti-cancer drug. The low-dose naltrexone and the methionine-enkephalin are combined via an opioid receptor on the surface of a cell of an immunity system of a body, so that effects of stimulating activation and proliferation of immune cells and improving an immune function can be realized. In addition, the combination of the low-dose naltrexone and the methionine-enkephalin is used for preparing the drug for treating cancers, so that a novel tumor biotherapy method with a breakthrough curative effect is formed, and the drug has the advantages of low dosage and side effect, high activity and safety, and the like.

Description

technical field [0001] The invention belongs to the field of immune regulation, and mainly relates to the application of a combination of medicines in the preparation of anticancer medicines, specifically, low-dose naltrexone (LDN) combined with methionine cerebrospinal peptide (MENK) is administered in vivo as a medicine for treating cancer Applications. Background technique [0002] Cancer treatment includes surgery, radiation therapy, chemotherapy, and biological therapy. The method of treating cancer by regulating the body's immune cells is called tumor immunotherapy technology, which belongs to the category of biological therapy. It is to inhibit or kill tumor cells by adjusting or enhancing the body's inherent defense mechanism, or to reduce the malignancy of tumors by inhibiting the transformation of tumor cells. The specific mechanism is as follows: 1. Exogenous administration of immunostimulators or modulators to correct the underlying state of immune function. 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K31/485A61P35/00
Inventor 单风平诺瑞·格瑞芬尼古拉菠萝尼科夫
Owner 单风平
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