33 results about "Drug detoxification" patented technology

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

A filter and a method of forming a suture structure. The filter includes layered structure(s) interior to the filter. Each layered structure includes a carbon structure comprising carbon and a coating on a surface of the carbon structure. Each layered structure may further include a heparin layer that includes heparin and is on the coating. The coating of the filter includes cellulose, PMMA, PEMA, or PHEMA. The carbon structure may include an activated charcoal layer or carbon nanotube(s). The layered structure is configured to remove a contaminant flowing through the filter. The method of forming the suture structure includes forming a film on a suture that has been previously formed on a mammal. The film includes both a coating on the suture and a heparin layer that includes heparin and is on the coating. The coating of the suture structure includes cellulose, PMMA, PEMA, or PHEMA.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention discloses a low-frequency therapeutic apparatus for drug detoxification, which is regulated and controlled by a computer and is equipment for the drug detoxification and solves the problem of poor effects of healing with drugs for the drug detoxification in the past. The low-frequency therapeutic apparatus for the drug detoxification, regulated and controlled by the computer, comprises a power source and a shell, the shell is internally provided with a controller and the input end of the controller is connected with the computer while the output end of the controller is connected with a therapeutic electrode. By virtue a method of acupuncture points and meridians in the traditional Chinese medical science, a pulse signal generated by the driving of the controller by the computer passes through the therapeutic electrode and a skin electric shocking pulse is directly adopted to stimulate acupuncture points of a human body for treatment, thus promoting the releasing of enkephalin in the human body, further relieving the withdrawal symptoms of opiate narcotics and having the effects of pain easing and spasmolysis and better withdrawal effect than amidone methadone. The therapeutic apparatus of the invention has safe and reliable application, no pain, no side effect, and obvious effects for relieving addiction and controlling relapse. The computer is used for regulating and controlling so as to realize simple operation and accurate curative effect.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention relates to a Chinese herbal medicine composition used for detoxification treatment. The material composition for preparing the effective components of the composition is listed as follows according to weight shares: rhizoma corydalis 100 to 10000 shares, greater celandine 200 to 20000 shares, radix stephaniae cepharanthae 200 to 20000 shares, radix stephaniae tetrandrae 100 to 10000 shares, hyoscyamus niger 3 to 300 shares, angelica sinensis 75 to 7500 shares, tuber fleeceflower 10 to 1000 shares, medlar 20 to 2000 shares, ginseng 8 to 800 shares, albizzia peel 100 to 10000 shares, spine data seed 40 to 4000 shares, radix glycyrrhizae 75 to 7500 shares. The Chinese herbal medicine composition has the functions of antispasmodic, taking away the pain, cooling blood, detoxifying, relieving cough and eliminating phlegm, diuresis, soothing the nerves, nourishing liver and kidney, nourishing yin and producing energy, reinforcing spleen and strengthening lung, reinforcing qi and nourishing blood, soothing the nerves and promoting intelligence, soothing the nerves and fixing the sensorium and supporting the healthy energy, and can be used for acute withdrawal of opioid addiction.

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

The invention discloses an intelligent drug detoxification management method using rehabilitation training. The method comprises the following steps: the drug detoxification personnel identity information is inputted into a management platform; physical examination is performed on all the drug detoxification personnel and the examination report information is inputted into the management platform;the personnel are divided into the special group and the general group according to the physical examination result; the rehabilitation training courses for the corresponding diseases are allocated to the special group; the further physique test is performed on the normal patients; the management platform allocates regular group rehabilitation training courses and individual targeted rehabilitation training courses to the general group according to the physique test result; the drug detoxification personnel obtain the rehabilitation training courses; the bracelet collects exercise status datainformation; and alarming is performed if the amount of exercise exceeds the preset value of the bracelet. The management platform is applied to formulate the targeted training plan and the rehabilitation scheme for the drug detoxification personnel, and the exercise data and the physical condition data of the drug detoxification personnel are collected through the bracelet so as to achieve intelligent management.

The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also provided are methods of treating depression and affective disorders, such as obsessive compulsive disorder. Pharmaceutical compositions of the fluvoxamine analogs are also taught.

This invention is drawn to compounds which are more easily metabolized by the metabolic drug detoxification systems. Particularly, warfarin analogs which have been designed to include esters within the structure of the compounds are taught. The invention teaches methods of reducing the toxicity of drugs comprising the introduction of ester groups into drugs during the synthesis of the drug. This invention is also drawn to methods of treating coagulation disorders comprising the administration of compounds which have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester containing warfarin, analogs are also taught.

The invention discloses an LED (light emitting diode) multi-path irradiating drug detoxification apparatus, and belongs to the field of optical medical equipment. The LED multi-path irradiating drug detoxification apparatus transfers the comprehensive therapy effect of the present mature technology on the human body to a detoxification manner, adopts a high-brightness LED light source to carry out multi acupuncture point irradiation simulation to cause polypeptide substance 'endorphin' similar to morphine inherent in the brain to be weakened and enhance the self drug resistance, combines LED capillary external irradiation to replace or partially replace the pure drug detoxification, has the obvious advantages that drug abstainers are easy to accept, the detoxification is convenient, no side effects is caused, and the cost is low, not only stably detoxicates, but also enhances the immunity, reduces and prevent the relapse. Compared with a traditional therapeutic apparatus adopting a laser light source, the drug detoxification apparatus has a simple structure, is rich in therapy wave band, adjustable in irradiation power, wider in application range as compared with a traditional laser therapy method, is higher in flexibility, and lower in cost.

The invention relates to a quick drug detoxification capsule which utilizes the pure natural plants and animals medicinal materials such as ginseng, bear bile powder, costus root, houttuynia cordata, frankincense, myrrh, gardenia, processed fumitory, artificial bezoar, shinyleaf pricklyash root, rhizoma gastrodiae, aconite, caulis polygoni multiflori, himalayan teasel root, processed henbane, rhubarb, earthworm, date core, donkey-hide glue, aweto, panax notoginseng, pilose antler, and other materials, which are processed into tiny powders and then into capsules. The capsule of the invention is quick in drug detoxification, nonirritating and has no toxic and side effect, and can relieve the pain of the drug taker in the greatest degree and eliminate the physical and psychological dependence of drug takes, without any new dependence, so the capsule of the invention can help achieve the aim of drug detoxification and recovery.

The invention relates to a traditional Chinese medicine and a preparation process thereof, in particular to a Chinese medical drug abstinence tablet and a preparation process thereof. The drug abstinence tablet consists of various traditional Chinese medicines such as codonopsis pilosula, radix glycyrrhizae preparate, tortoise-shell glue and angelica sinensis, and is prepared by applying a modern traditional Chinese medicine extraction technology through digesting, filtering, concentrating, drying and grinding, and mixing with fine powder of a fructus amomi adhesive tablet. The Chinese medical drug abstinence tablet is used for quick de-addiction and detoxification of withdrawal syndrome in withdrawal of abused opiates, and mainly used for drug detoxification for patients with addiction to taking opiates and taking or injecting heroin, demerol, dihydroetorphine, codeine and the like. The Chinese medical drug abstinence tablet has the efficacies of being anti-anxiety and fast in de-addiction, avoiding narcotic retaking, coordinating autonomic nervous system, improving blood flow, activating cells of a whole body when the drug abstinence tablet disperses throughout the whole body, accelerating metabolism, and eliminating vivotoxin and hepatic and renal toxin, so as to improve human immunity and the quality of life, and enable normal human physiological functions of drug addicts to be restored.

A method of detoxifying a patient addicted to at least one drug comprises the step of administering a first-medication component to the patient for mitigating drug withdrawal symptoms of the patient. The method further comprises the step of administering an anesthetic component to the patient for putting the patient in a sedated state. The method further comprises the step of administering a detoxification component to the patient for detoxifying the patient of the drug(s) while the patient is in the sedated state. The detoxification component can comprise naloxone. The method further comprises the step of administering a second-medication component to the patient for further mitigating drug withdrawal symptoms of the patient while the patient is in the sedated state. The second-medication component can comprise naltrexone. The method further comprises the step of terminating administration of the anesthetic component to the patient for reviving the patient from the sedated state.

The invention relates to the application of baclofen in the opium drug abstinence treatment and belongs to the technical field of addiction medicine application. According to the characteristic of baclofen GABA beta-receptor stimulant, the invention applies the baclofen with the daily dosage of 15 to 120mg as the drug for the opium drug abstinence treatment by virtue of the mutual reaction relation between the baclofen GABA beta-receptor stimulant and an opium system, the close relation between a GABA beta-receptor and the opium drug acute abstinence, the advantages of the GABA beta-receptor stimulant reducing the exacting action of the opium drug, etc. The baclofen is concretely applied in the comprehensive treatments, such as opium drug detoxification (acute abstinence symptom), healing (protracted abstinence syndrome and overcoming psychological dependence), etc. The clinical trial shows that the invention not only develops the application range of traditional drugs, but also has the advantages of investment saving, the low cost of product, strong practicability, good effect, etc. The baclofen can be widely applied to the opium drug abstinence detoxification and healing treatment.

The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also provided are methods of treating depression and affective disorders, such as obsessive compulsive disorder. Pharmaceutical compositions of the fluvoxamine analogs are also taught.

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

A method of homogeneously forming functionalized biocompatible oligomers includes the steps of dissolving a biocompatible oligomer in a solvent to form a solution, and admixing at least one π complex forming group to the solution, wherein the π complex forming group grafts to at least one location on the backbone of the oligomer to form a grafted oligomer. The oligomer is preferably oligochitosan and the solvent is preferably dimethylsulfoxide (DMSO). The degree of graft substitution can be at least 50%. The functionalized biocompatible oligomer can be used for drug detoxification through binding to a variety of target drugs.

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

The invention relates to the application of paralest in the opium drug detoxification abstinence treatment and belongs to the technical field of addiction medicine application. According to the functional characteristics of paralest of selectively breaking the cholinergic nerve tract of striaturn, inhibiting the hyperfunction of acetylcholine, correspondingly improving the effect of brain dopamine, being good for keeping or recovering the balance of two transmitter systems of striaturn dopamine (DA) and acetylcholine (Ach) and causing no drug dependence after long time usage, the paralest is used for the treatments, such as opium drug detoxification (acute abstinence symptom), healing (protracted abstinence syndrome), etc. Experimentation on animals and clinical trial show that the invention not only develops the application range of traditional drugs, but also has the advantages of investment saving, the low cost of product, strong practicability, good effect, etc. The paralest can be widely applied to the opium drug abstinence treatment.

A pure traditional Chinese medicine for drug withdrawal and a preparation method thereof. The medicine is made of the following raw materials: astragalus, polygala, codonopsis, ginseng, baiziren, Fushen, jujube seed, uncaria, corydalis, salvia, frankincense (made) . The raw materials are processed by crushing or slicing, extracting, concentrating, drying, mixing, forming and other processes by modern technology. This drug has the functions of strengthening the body, nourishing qi and calming the nerves, relieving spasm and relieving pain, calming convulsions and quenching wind, and regulating yin and yang. It is clinically suitable for all patients who are poisoned by taking heroin and its derivatives or methamphetamine and its derivatives. And eliminate the withdrawal symptoms of opioid drugs, especially methamphetamine drugs (ice, magu, K powder, ecstasy, etc.), and relieve drug addiction. More than 3,000 clinical trials have shown that the curative effect of detoxification is obvious, and it is safe to use according to the recommended dose, without toxic and side effects, and can be applied clinically.

The present invention provides the use of Entauren in the preparation of drugs for detoxification, that is, a new application of Entaurea for drug withdrawal; Entaurea is widely used as an early analgesic for acute trauma As well as drugs in operations and other invasive medical operations that require a short analgesic time, they have the advantages of being safe, effective, simple, economical, non-invasive, and can replace narcotic analgesics. They can activate the central nervous system and promote endogenous The release of opioid peptides can supplement the lack of endorphins released by the body due to long-term drug use. Old drugs are used for new purposes, and the scope of application can be broadened as a drug detoxification drug. At the same time, Antaile can also relieve the pain caused by withdrawal symptoms and relieve anxiety. Reduce acute sudden death caused by severe withdrawal symptoms, so that drug addicts can stay awake, relaxed, comfortable and cooperate with treatment without pain during the entire detoxification treatment process.

The invention discloses a low-frequency therapeutic apparatus for drug detoxification, which is regulated and controlled by a computer and is equipment for the drug detoxification and solves the problem of poor effects of healing with drugs for the drug detoxification in the past. The therapeutic apparatus comprises a power source and a shell, the shell is internally provided with a controller and the input end of the controller is connected with the computer while the output end of the controller is connected with a therapeutic electrode. By virtue a method of acupuncture points and meridians in the traditional Chinese medical science, a pulse signal generated by the driving of the controller by the computer passes through the therapeutic electrode and a skin electric shocking pulse is directly adopted to stimulate acupuncture points of a human body for treatment, thus promoting the releasing of enkephalin in the human body, further relieving the withdrawal symptoms of opiate narcotics and having the effects of pain easing and spasmolysis and better withdrawal effect than amidone methadone. The therapeutic apparatus has safe and reliable application, no pain, no side effect, and obvious effects for relieving addiction and controlling relapse. The computer is used for regulating and controlling so as to realize simple operation and accurate curative effect.

A medicine for treating intractable piglet diarrhea, characterized in that it is made of the following components in parts by weight: 1-3 parts of borax, 10 parts of 5% hydrochloric acid and 0.025 parts of novocaine injection, or tablets made with 1.5 parts of tannic acid and 0.5 parts of starch as auxiliary materials, or oral liquid made with 10 parts of 5% hydrochloric acid and 0.09 parts of artificial salt as auxiliary materials. The medicine of the invention has the effects of clearing away heat, detoxifying, antibacterial and stopping dysentery, has quick effect and high cure rate in treating obstinate piglet diarrhea. The preparation method of the medicine has the advantages of simple production process, low production cost, high efficiency, long-acting, small dose, low toxicity, no side effect and the like.

The invention relates to a veterinary drug, in particular to a scourge and toxin clearing drug. The main purpose of the invention is to provide a scourge and toxin clearing drug with low side effect. The scourge and toxin clearing drug has the formula as follows: 60 g of gypsum, 30-45 g of radix rehmanniae recen, 60 g of cornu bubali, 20 g of coptis chinensis, 35-45 g of jasmine, 20 g of moutan bark, 25 g of scutellaria baicalensis, 30 g of root of common peony, 30 g of rhizoma anemarrhenae, 30 g of fructus forsythiae, 25 g of platycodon grandiflorum, 15 g of liquorice and 25 g of lophatherum gracile. The drug obviously decreases the dosage of gypsum, reduces the cold property of the drug, and relieves the harm to animal bodies and the side effect; however, the original effects of the drug are maintained through properly adjusting the dosage of other components; the curative effect is definite and prominent; the drug property is milder. Radix scrophulariae is not used, so that the formula of the drug is simplified; the raw materials and the processing cost of the drug are reduced.

The invention discloses a pharmaceutical composition, which is composed of grape powder, ginseng powder, ginkgo fruit powder and krill oil. The invention also discloses the application of the pharmaceutical composition in preparing drug for detoxification. Animal test results show that: (1) the composition can reduce methamphetamine-induced mouse conditioned place preference and reduce the addiction of mice to methamphetamine; (2) can improve the memory function of methamphetamine-exposed mice , has a protective effect on central nervous system damage caused by methamphetamine; (3) can significantly improve the anxiety and depression behaviors of mice caused by methamphetamine; (4) has the effect of improving sleep. The above results show that the present invention can reduce the addiction of animals to methamphetamine, protect the central nervous system and repair brain damage, thereby exerting the effects of detoxification and improving the quality of life of patients.

A purpose of Biperiden Hcl is mainly to be provided to the patient to sooth brain disorder of the patient after the patient is treated with drug detoxification such that consciousness of the patient can be recovered to rapidly become normally physiological state.