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Use of baclofen in withdrawal treatment of opium drug

An opioid and baclofen technology, applied in the application field of addiction medicine, can solve the problems of high cost, single effect, large side effects, etc., and achieve the effects of low product cost, quick effect, and prevention of relapse

Inactive Publication Date: 2009-04-01
袁才尉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many kinds of drug treatments in drug rehabilitation, but the problems of high cost, large side effects and single effect are more prominent

Method used

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  • Use of baclofen in withdrawal treatment of opium drug
  • Use of baclofen in withdrawal treatment of opium drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Once opioids are discontinued and acute withdrawal symptoms occur, baclofen is administered three times a day (morning, noon, and evening). Take 5-10mg each time on the first day, 10-20mg each time from the second to the fourth day, 10mg each time from the fifth to the sixth day, and 5mg each time on the seventh day.

Embodiment 2

[0023] When protracted withdrawal symptoms occur during the recovery phase, baclofen is taken three times a day (morning, noon, and evening). Take 10mg each time on the first day, 20mg each time from the second to the third day, and 10mg each time on the fourth day.

Embodiment 3

[0025] When drug-seeking behavior and psychological craving behavior appeared, baclofen was taken three times a day (morning, noon and evening). Take 5mg each time on the first day, 10mg each time from the second to the fourth day, and 5mg each time from the fifth to the seventh day. After three months, repeat the above taking method to consolidate the effect.

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PUM

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Abstract

The invention relates to the application of baclofen in the opium drug abstinence treatment and belongs to the technical field of addiction medicine application. According to the characteristic of baclofen GABA beta-receptor stimulant, the invention applies the baclofen with the daily dosage of 15 to 120mg as the drug for the opium drug abstinence treatment by virtue of the mutual reaction relation between the baclofen GABA beta-receptor stimulant and an opium system, the close relation between a GABA beta-receptor and the opium drug acute abstinence, the advantages of the GABA beta-receptor stimulant reducing the exacting action of the opium drug, etc. The baclofen is concretely applied in the comprehensive treatments, such as opium drug detoxification (acute abstinence symptom), healing (protracted abstinence syndrome and overcoming psychological dependence), etc. The clinical trial shows that the invention not only develops the application range of traditional drugs, but also has the advantages of investment saving, the low cost of product, strong practicability, good effect, etc. The baclofen can be widely applied to the opium drug abstinence detoxification and healing treatment.

Description

Technical field: [0001] The invention relates to the application of baclofen in the treatment of opioid drug withdrawal, and belongs to the technical field of addiction medicine application. Background technique: [0002] Baclofen, whose chemical name is 4-amino-3-(4-chlorophenyl)-butyric acid, is traditionally used as an antispasmodic and is a derivative of γ-aminobutyric acid (GABA). Skeletal muscle relaxants and sedatives in the spinal cord. The drug inhibits the release of excitatory amino acids such as glutamic acid and aspartic acid by stimulating GABAβ-receptors, thereby inhibiting the transmission of monosynaptic and polysynaptic reflexes in the spinal cord and has an antispasmodic effect. In terms of clinical indications, baclofen is used to relieve skeletal muscle spasms caused by the following diseases: 1. Multiple sclerosis, syringomyelia, spinal cord tumors, transverse myelitis, spinal cord trauma and motor neuron disease; 2. Cerebrovascular diseases , cerebra...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61P25/36
Inventor 袁才尉
Owner 袁才尉
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