Stable buffered, pharmaceutical compositions including motilin-like peptides

A technology of motilin-like peptides and compositions, which is applied in the field of pharmaceutical compositions of motilin-like peptides, and can solve problems such as difficult stability
CN101198350AInactive Publication Date: 2008-06-11BAXTER INT INC +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BAXTER INT INC
Publication Date
2008-06-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses stable pharmaceutical compositions containing synthetic motilin-like polypeptides in buffer. The composition provides a peptide that remains stable and substantially retains its starting potency after prolonged storage and steam sterilization.
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Description

[0001] Cross reference to other related applications

[0001] This application claims the benefit of US Provisional Application 60 / 691,555, filed June 17, 2005, the contents of which are hereby incorporated by reference.

[0002] The present invention relates to pharmaceutical compositions containing motilin-like peptides. More specifically, the present invention relates to pharmaceutical compositions containing motilin-like peptides that remain stable and retain their potency and binding affinity after prolonged storage. Background of the invention

[0003] Motilin peptide is a linear polypeptide hormone of the gastrointestinal tract that stimulates the motility activity of the mammalian gastrointestinal tract. Motilin enhances gastric motility by modulating interdigestive myoelectric complexes. Administration of motilin to human patients accelerates their intestinal transit and enhances gastric emptying [Christofides et al., Gastroenterology 76, 903-907 (1979)]. In vitro ...

Claims

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