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Application of pharmaceutical composition in preparation of Chinese herba preparation for treating functional dyspepsia

A technology of indigestion and traditional Chinese medicine preparations, applied in the field of medicine, can solve the problems of FD pathogenesis not fully clarified, movement disorders, etc., and achieve safe and effective treatment and reduce the effect of content

Inactive Publication Date: 2017-11-21
HANGZHOU HUQINGYUTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the pathogenesis of FD has not been fully clarified. Existing clinical studies have shown that it may be related to gastrointestinal motility disorder, increased visceral sensitivity, changes in gastrointestinal hormones and neurotransmitters, autonomic nervous dysfunction, psychosocial and psychological factors, Helicobacter pylori (HP) infection, gastric acid, sex hormones, genetics and many other factors are related (see: He Meirong. Research overview on the relationship between non-ulcer dyspepsia and gastrointestinal hormones [J]. Medical Review, 2002, 8(2): 92-94)

Method used

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  • Application of pharmaceutical composition in preparation of Chinese herba preparation for treating functional dyspepsia
  • Application of pharmaceutical composition in preparation of Chinese herba preparation for treating functional dyspepsia
  • Application of pharmaceutical composition in preparation of Chinese herba preparation for treating functional dyspepsia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A pharmaceutical composition comprising the following raw materials in parts by weight:

[0031] Fragrant tea 25 servings

[0032] Bran-fried Fructus Fructus 2.5 parts

[0033] 1.31 parts of red ginseng.

[0034] The preparation of pharmaceutical composition comprises:

[0035] (1) Add 4 times of water to 25 parts of fragrant tea vegetables, decoct twice for 3 hours each time, settle, filter, and set aside the filtrate;

[0036] (2) Add 2.5 parts of fried Fructus Fructus Fructus Bran to 4 times of water, decoct twice for 1 hour each time, settle, filter, and use the filtrate for later use;

[0037] (3) 1.31 parts of red ginseng are crushed into fine powder;

[0038] (4) Combine the filtrates obtained in (1) and (2), concentrate to a clear paste with a density of 1.13-1.18 (20°C), add the red ginseng fine powder obtained in (3), 0.3 parts of starch and 0.3% stearin Magnesium acid, mixed, granulated, dried, compressed into tablets, coated to obtain the tablet of the ...

Embodiment 2

[0040] A pharmaceutical composition comprising the following raw materials in parts by weight:

[0041] Fragrant tea 25 servings

[0042] Bran fried citrus 3 servings

[0043] 1.5 parts of red ginseng.

[0044] The preparation of pharmaceutical composition comprises:

[0045] (1) Add 6 times of water to 25 parts of fragrant tea vegetables, heat and reflux twice, each time for 3 hours, precipitate, filter, and the filtrate is set aside;

[0046] (2) Stir 3 parts of bran and add 4 times of water to Fructus Fructus Aurantii, heat and reflux twice for 2 hours each time, settle, filter, and use the filtrate for later use;

[0047] (3) 1.5 parts of red ginseng are crushed into fine powder;

[0048] (4) Combine the filtrates obtained in (1) and (2), concentrate to a clear paste with a density of 1.13-1.18 (20°C), add the red ginseng fine powder obtained in (3), mix, and dry to obtain the drug combination.

Embodiment 3

[0050] A pharmaceutical composition comprising the following raw materials in parts by weight:

[0051] Fragrant tea 30 servings

[0052] Bran fried citronella 2 parts

[0053] 2 servings of red ginseng.

[0054] The preparation of pharmaceutical composition comprises:

[0055] (1) Add 8 times of water to 30 parts of fragrant tea vegetables, decoct twice for 3 hours each time, settle, filter, and use the filtrate for later use;

[0056] (2) Add 8 times water to 2 parts of fried Fructus Fructus Aurantii, decoct twice for 3 hours each time, settle, filter, and set aside the filtrate;

[0057] (3) Grinding 2 parts of red ginseng into fine powder;

[0058] (4) Combine the filtrates obtained in (1) and (2), concentrate to a clear paste with a density of 1.13-1.18 (20°C), add the red ginseng fine powder obtained in (3), mix, and dry to obtain the drug combination.

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Abstract

The invention provides an application of a pharmaceutical composition in preparing a traditional Chinese medicine preparation for treating functional dyspepsia. The pharmaceutical composition comprises fenugreek, bran-fried citrus aurantium and red ginseng. The pharmaceutical composition is used for controlling body weight change caused by functional dyspepsia; for reducing the content of nitric oxide in serum; for regulating plasma gastrin, motilin, somatostatin and vasoactive intestinal peptide ; for enhancing the expression of tyrosine protein kinase receptor C-kit and mammary gland-related peptide TFF1 in gastric mucosa. The present invention utilizes a reasonable preparation method and combines the synergistic effects of fragrant tea vegetables, bran-fried citrus aurantium and red ginseng, and can effectively treat functional dyspepsia with little side effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of a traditional Chinese medicine preparation for treating functional dyspepsia. Background technique [0002] Red ginseng invigorates vitality and invigorates the spleen and stomach; fragrant tea and vegetables promote qi and blood circulation, clear away heat and dehumidify; stir-fried aurantium aurantium husk regulates qi mechanism, which can not only strengthen the dredging effect of spleen ascending and stomach descending, but also prevent excessive red ginseng tonic, stagnation of damp pathogens, and Enhance the efficacy of fragrant tea and vegetables to promote qi and dehumidify. The three work together to strengthen the spleen and replenish qi, activate blood and detoxify, promote qi and dehumidify. [0003] Functional dyspepsia (Functional dyspepsia, FD) is a common clinical functional disease of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P1/14
CPCA61K36/53A61K36/258A61K36/752A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 陈炜朱加明韩俊琦
Owner HANGZHOU HUQINGYUTANG PHARM CO LTD
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