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Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition

A technology of Evodia rutaecarpa and composition, applied in the field of pharmacy, to achieve the effect of increasing gastric emptying and intestinal propulsion, good therapeutic effect

Active Publication Date: 2013-07-10
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to research and design the application of Coptidis Rhizoma and Evodia rutaecarpa in the preparation of medicines for treating functional dyspepsia

Method used

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  • Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition
  • Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition
  • Application of medicament composition composed of coptis chinensis and fructus evodiae and preparation method of medicament composition

Examples

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Effect test

Embodiment 1

[0016] Weigh 100g of Coptidis rhizome and 100g of Evodia rutaecarpa as raw materials, add 200g of auxiliary materials starch to granulate, 4g of magnesium stearate, 100g of dextrin, and 100g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

Embodiment 2

[0018] Weigh 200g of Coptidis rhizome and 100g of Evodia rutaecarpa as raw materials, add 300g of auxiliary materials starch to granulate, 4g of magnesium stearate, 100g of dextrin, and 100g of microcrystalline cellulose, uniformly prepare granules, and press into tablets to obtain tablets.

Embodiment 3

[0020] Weigh 100 g of Coptis rhizome and 200 g of Evodia rutaecarpa as raw materials, add 300 g of auxiliary materials starch to granulate, 4 g of magnesium stearate, 100 g of dextrin, and 100 g of microcrystalline cellulose, uniformly prepare granules, and compress into tablets to obtain tablets.

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Abstract

The invention discloses new application of a medicament composition composed of coptis chinensis and fructus evodiae in preparation of a medicament for treating functional dyspepsia. The medicament composition is composed of the following components by weight: 1-30 parts of the coptis chinensis and 10-40 parts of the fructus evodiae. Efficacy experiment verification of the medicament composition shows that the capacity of gastric emptying and intestine propulsion of atropine gastrointestinal motility obstacle model mouse can be obviously improved, the content of motilin and gastrin of rat plasma can be obviously increased, and objective indicators of serum acetyl choline, acetylcholinesterase, choline acetyltransferase, and the like can be effectively enhanced after coptis chinensis and fructus evodiae are mixed and matched in a certain proportion. The medicament composition has good treatment effect on a functional dyspepsia patient.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a new application of a pharmaceutical composition composed of coptis and evodia rutaecarpa and a preparation method thereof. Background technique [0002] Dyspepsia is a clinical syndrome, which is a disease caused by gastric motility disorder, including gastroparesis and esophageal reflux disease with poor gastric motility. Clinically, it is mainly divided into functional dyspepsia and organic dyspepsia. The common symptoms are fullness in the epigastric cavity, stomach pain, uncomfortable stool, belching, etc. Those who have the above-mentioned dyspepsia symptoms without definite organic diseases that can be explained are called functional dyspepsia, which can be clearly identified after examination. Indigestion symptoms caused by certain organ diseases (such as liver disease, biliary tract disease, pancreatic disease, diabetes, etc.) are called organic dyspepsia. [0003] At present, We...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/14A61K36/718
Inventor 沈涛薛红徐世军
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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